Zobrazeno 1 - 10
of 51
pro vyhledávání: '"veeraswamy manne"'
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16545 (2011)
Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical
Externí odkaz:
https://doaj.org/article/3d4bc5b97eb745c5b8b85ffdefa4701c
Autor:
Jyoti Malhotra, Joshua A. Vieth, Marisa Palmeri, Nancy Chan, Kristen Spencer, Robert M. Berman, Janice M. Mehnert, Ann W. Silk, Weichung Shih, Suzie Chen, Biren Saraiya, Vlad Coric, Roman Groisberg, Veeraswamy Manne, Eugenia Girda
Publikováno v:
Journal of Clinical Oncology. 38:79-79
79 Background: The Metabotropic Glutamate Receptor 1 (GRM1) is overexpressed in many solid tumors. It activates MAPK and PI3K/AKT pathways and promotes an immune-suppressive tumor microenvironment. In an immunocompetent melanoma mouse model, GRM1 blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::629a8a84dcf8fe963ddd51cb1d01dbe4
https://doi.org/10.1200/jco.2020.38.5_suppl.79
https://doi.org/10.1200/jco.2020.38.5_suppl.79
Autor:
Oksana Lockridge, Kalpana Parikh, Neil S. Jensen, Veeraswamy Manne, Ellen G. Duysen, Nageswararao Chilukuri, Benjamin Snow
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:92-101
Gene delivery using an adenoviral system has been effective in introducing therapeutic proteins in vitro and in vivo. This study tested the feasibility of using adenovirus to deliver clinically relevant amounts of butyrylcholinesterase (BChE), a prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f7281c1cd6e944f663340a2612a25b
https://doi.org/10.1124/jpet.110.175646
https://doi.org/10.1124/jpet.110.175646
Autor:
David K. Williams, Kristen A. Kellar, Louis J. Lombardo, Veeraswamy Manne, Joseph Fargnoli, John S. Tokarski, Xiao-Tao Chen, Robert Jeyaseelan, Yongmi An, Barri Wautlet, Robert M. Borzilleri, George L. Trainor, Robert F. Kaltenbach, Benjamin J. Henley, Christine M. Tarby, John S. Sack, Zhen-Wei Cai, Johnni Gullo-Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2998-3002
Biarylamine-based inhibitors of Met kinase have been identified. Lead compounds demonstrate nanomolar potency in Met kinase biochemical assays and significant activity in the Met-driven GTL-16 human gastric carcinoma cell line. X-ray crystallography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce111ff8f72247a524ba96836e34c3c8
https://doi.org/10.1016/j.bmcl.2010.01.042
https://doi.org/10.1016/j.bmcl.2010.01.042
Autor:
Robert J. Schmidt, Benjamin J. Henley, Celia D’Arienzo, Jonathan Lippy, John S. Sack, Yueping Zhang, Yongmi An, John T. Hunt, Amrita Kamath, John S. Tokarski, Barri Wautlet, Veeraswamy Manne, Dianlin Xie, Punit Marathe, Donna D. Wei, Louis J. Lombardo, Kyoung S. Kim, Robert Jeyaseelan, David K. Williams, Joseph Fargnoli, Liping Zhang, Yaquan Zhang, Johnni Gullo-Brown, Zhen-Wei Cai, George L. Trainor, Robert M. Borzilleri
Publikováno v:
Journal of Medicinal Chemistry. 51:5330-5341
Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an IC50 value of 1.8 nM. Further SAR of the 2-pyridone based inhibitors of Met kinase led to potent 4-pyridone and pyridine N-oxide inhibitors such as 3 and 4. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58a9baa70cfbe1d4ab37df5d6a6a243
https://doi.org/10.1021/jm800476q
https://doi.org/10.1021/jm800476q
Autor:
Amrita Kamath, Yongmi An, John T. Hunt, Punit Marathe, Veeraswamy Manne, Zhen-Wei Cai, Donna D. Wei, John S. Sack, Robert J. Schmidt, Yueping Zhang, Robert M. Borzilleri, Kyoung S. Kim, Cornelius Lyndon A M, Gretchen M. Schroeder, David K. Williams, Xiao-Tao Chen, Joseph Fargnoli, Louis J. Lombardo, John S. Tokarski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3224-3229
A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5541a60335288c14cacaac51532ac11
https://doi.org/10.1016/j.bmcl.2008.04.047
https://doi.org/10.1016/j.bmcl.2008.04.047
Autor:
Johnni Gullo-Brown, Michael A. Poss, Wayne Vaccaro, Tram N. Huynh, Stephanie Barbosa, Carolyn S. Ricca, Mark E. Salvati, Veeraswamy Manne, Zhong Chen, Kenneth J. Leavitt, Soong-Hoon Kim, David R. Tortolani, Donna D. Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:628-632
The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b1ce0dc69568349a8c7b57436978aa
https://doi.org/10.1016/j.bmcl.2005.10.052
https://doi.org/10.1016/j.bmcl.2005.10.052
Autor:
Hangjun Zhan, Hong Xiao, Katherine Brown, Yvonne Franke, Bo Guan, Kevin Patrick Keegan, Michael Robert Cancilla, Rachel M. Kindt, Rajashekar K. Reddy, Changyou Chen, Juan J. Perez-Villar, Tim Heuer, Dianne Parry, Veeraswamy Manne, Carol O'Brien, Mark I. Cockett, Greg D Plowman, Kevin Fitzgerald, Petra Ross-Macdonald, Mark R. Lackner, Pamela M. Carroll, Michael Costa, Jae Moon Lee, Tak Hung, Heshani de Silva
Publikováno v:
Cancer Cell. 7:325-336
SummaryA chemical genetics approach identified a cellular target of several proapoptotic farnesyl transferase inhibitors (FTIs). Treatment with these FTIs caused p53-independent apoptosis in Caenorhabditis elegans, which was mimicked by knockdown of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cb404a66039d651e12d1d925e26ee1
https://doi.org/10.1016/j.ccr.2005.03.024
https://doi.org/10.1016/j.ccr.2005.03.024
Autor:
Eric M. Gordon, Bernd R. Seizinger, Anne V. Tuomari, Simon P. Robinson, Joan M. Carboni, Ning Yan, Mariano Barbacid, Scott A. Biller, Carl P. Ciosek, Veeraswamy Manne, Robert J. Schmidt, Carolyn S. Ricca, Johnni Gullo Brown, Mark Lynch, Dinesh V. Patel
Publikováno v:
Drug Development Research. 34:121-137
Protein prenylation is increasingly recognized as an important mechanism by which functional association of proteins to membranes is mediated. Ras proteins, regulators of cell proliferation and differentiation, are among the proteins that undergo far
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f26f567990ac1703dfcd382d0a2303
https://doi.org/10.1002/ddr.430340205
https://doi.org/10.1002/ddr.430340205
Autor:
Simon P. Robinson, Young Cho, Bernd R. Seizinger, Jelka Pluscec, Katerina Leftheris, Carolyn S. Ricca, M. K. DeVirgilio, Toni B. Kline, Veeraswamy Manne, Chester A. Meyers, Sesha Natarajan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:887-892
A systematic study of CVFM, a CAAX-derived farnesyl transferase inhibitor, was undertaken to determine the structural elements important for intrinsic activity as well as substrate character. Results indicate a narrowly defined profile for nonsubstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0dde2a2eeb1dc49aa22b0307c790e1
https://doi.org/10.1016/s0960-894x(01)80257-2
https://doi.org/10.1016/s0960-894x(01)80257-2