Zobrazeno 1 - 7
of 7
pro vyhledávání: '"variant PTPN22"'
Autor:
Andrea Arena, Eugenia Belcastro, Francesca Ceccacci, Stefania Petrini, Libenzio Adrian Conti, Olivia Pagliarosi, Ezio Giorda, Simona Sennato, Riccardo Schiaffini, Peng Wang, James C. Paulson, Giovanna Mancini, Alessandra Fierabracci
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The C1858T variant of the protein tyrosine phosphatase N22 (PTPN22) gene is associated with pathophysiological phenotypes in several autoimmune conditions, namely, Type 1 diabetes and autoimmune thyroiditis. The R620W variant protein, encoded by C185
Externí odkaz:
https://doaj.org/article/c86b2a3367494fe0855a574d4b729e5b
Autor:
Andrea Arena, Eugenia Belcastro, Antonella Accardo, Annamaria Sandomenico, Olivia Pagliarosi, Elisabetta Rosa, Stefania Petrini, Libenzio Adrian Conti, Ezio Giorda, Tiziana Corsetti, Riccardo Schiaffini, Giancarlo Morelli, Alessandra Fierabracci
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 408
International Journal of Molecular Sciences, Vol 23, Iss 408, p 408 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 408
International Journal of Molecular Sciences, Vol 23, Iss 408, p 408 (2022)
Autoimmune endocrine disorders, such as type 1 diabetes (T1D) and thyroiditis, at present are treated with only hormone replacement therapy. This emphasizes the need to identify personalized effective immunotherapeutic strategies targeting T and B ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586fdbfa44e8cc843a0c9c4014fdbb20
https://pubmed.ncbi.nlm.nih.gov/35008834
https://pubmed.ncbi.nlm.nih.gov/35008834
Akademický článek
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Autor:
Giovanna Mancini, Serena De Santis, Stefania Petrini, Alessandra Fierabracci, Marsha Pellegrino, Marco Cappa, Anita Scipioni, Francesca Ceccacci
Publikováno v:
Nanomedicine (Online) 18 (2019): 371–379. doi:10.1016/j.nano.2018.11.001
info:cnr-pdr/source/autori:Pellegrino M. (a); Ceccacci F. (b); Petrini S. (c); Scipioni A. (d); De Santis S. (d); Cappa M. (e); Mancini G. (f); Fierabracci A. (a)/titolo:Exploiting novel tailored immunotherapies of type 1 diabetes: Short interfering RNA delivered by cationic liposomes enables efficient down-regulation of variant PTPN22 gene in T lymphocytes/doi:10.1016%2Fj.nano.2018.11.001/rivista:Nanomedicine (Online)/anno:2019/pagina_da:371/pagina_a:379/intervallo_pagine:371–379/volume:18
info:cnr-pdr/source/autori:Pellegrino M. (a); Ceccacci F. (b); Petrini S. (c); Scipioni A. (d); De Santis S. (d); Cappa M. (e); Mancini G. (f); Fierabracci A. (a)/titolo:Exploiting novel tailored immunotherapies of type 1 diabetes: Short interfering RNA delivered by cationic liposomes enables efficient down-regulation of variant PTPN22 gene in T lymphocytes/doi:10.1016%2Fj.nano.2018.11.001/rivista:Nanomedicine (Online)/anno:2019/pagina_da:371/pagina_a:379/intervallo_pagine:371–379/volume:18
In autoimmune diseases as Type 1 diabetes, the actual treatment that provides the missing hormones is not able, however, to interrupt the underlining immunological mechanism. Importantly, novel immunotherapies are exploited to protect and rescue the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6678067b9235399241c9ed0c8e0ccfdc
https://hdl.handle.net/11590/363610
https://hdl.handle.net/11590/363610
Akademický článek
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Akademický článek
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Autor:
Arena A; Infectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00146 Rome, Italy., Belcastro E; Infectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00146 Rome, Italy., Accardo A; Research Centre on Bioactive Peptides (CIRPeB), Department of Pharmacy, University of Naples Federico II, 80134 Naples, Italy., Sandomenico A; Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), 80134 Naples, Italy., Pagliarosi O; Infectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00146 Rome, Italy., Rosa E; Research Centre on Bioactive Peptides (CIRPeB), Department of Pharmacy, University of Naples Federico II, 80134 Naples, Italy., Petrini S; Confocal Microscopy Core Facility, Research Laboratories, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00146 Rome, Italy., Conti LA; Confocal Microscopy Core Facility, Research Laboratories, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00146 Rome, Italy., Giorda E; Research Laboratories, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00146 Rome, Italy., Corsetti T; Unit of Hospital Pharmacy, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00165 Rome, Italy., Schiaffini R; Diabetes and Growth Pathology Unit, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00165 Rome, Italy., Morelli G; Research Centre on Bioactive Peptides (CIRPeB), Department of Pharmacy, University of Naples Federico II, 80134 Naples, Italy., Fierabracci A; Infectivology and Clinical Trials Research Department, Bambino Gesù Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), 00146 Rome, Italy.
Publikováno v:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 30; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 30.