Zobrazeno 1 - 10
of 304
pro vyhledávání: '"var gene"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The human malaria parasite Plasmodium falciparum maintains the chronicity of infections through antigenic variation, a well-coordinated immune evasion mechanism. The most prominent molecular determinant of antigenic variation in this parasite include
Externí odkaz:
https://doaj.org/article/a832e158b8f04d958446b4acd4036e72
Publikováno v:
mSphere, Vol 7, Iss 5 (2022)
ABSTRACT Sir2 protein of Plasmodium falciparum has been implicated to play crucial roles in the silencing of subtelomeric var genes and rRNA. It is also involved in telomere length maintenance. Epigenetic regulation of PfSIR2 transcription occurs thr
Externí odkaz:
https://doaj.org/article/f8e1462123354a8188d5b3e913d6ce43
Akademický článek
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Autor:
Wei-Feng Wang, Yi-Long Zhang
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Various transcription factors are involved in the process of mutually exclusive expression and clonal variation of the Plasmodium multigene (var) family. Recent studies revealed that a P. falciparum SWI/SNF-related matrix-associat
Externí odkaz:
https://doaj.org/article/132b588b348046b280fd4ad50f3b9777
Akademický článek
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Autor:
Emily M. Stucke, Antoine Dara, Ankit Dwivedi, Theresa K. Hodges, Sandra Ott, Drissa Coulibaly, Abdoulaye K. Koné, Karim Traoré, Bouréima Guindo, Bourama M. Tangara, Amadou Niangaly, Modibo Daou, Issa Diarra, Youssouf Tolo, Mody Sissoko, Luke J. Tallon, Lisa Sadzewicz, Albert E. Zhou, Matthew B. Laurens, Amed Ouattara, Bourema Kouriba, Ogobara K. Doumbo, Shannon Takala-Harrison, David Serre, Christopher V. Plowe, Mahamadou A. Thera, Mark A. Travassos, Joana C. Silva
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT var genes encode Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens. These highly diverse antigens are displayed on the surface of infected erythrocytes and play a critical role in immune evasion and sequestration of infe
Externí odkaz:
https://doaj.org/article/68627110cf9b45df9baabebd0ad00fb8
Autor:
Kathryn Milne, Alasdair Ivens, Adam J Reid, Magda E Lotkowska, Aine O'Toole, Geetha Sankaranarayanan, Diana Munoz Sandoval, Wiebke Nahrendorf, Clement Regnault, Nick J Edwards, Sarah E Silk, Ruth O Payne, Angela M Minassian, Navin Venkatraman, Mandy J Sanders, Adrian VS Hill, Michael Barrett, Matthew Berriman, Simon J Draper, J Alexandra Rowe, Philip J Spence
Publikováno v:
eLife, Vol 10 (2021)
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, ask
Externí odkaz:
https://doaj.org/article/70c326d1e81641cbb27a268a47c79208
Autor:
Cheryl A. Kivisi, Michelle Muthui, Martin Hunt, Greg Fegan, Thomas Dan Otto, George Githinji, George M. Warimwe, Richard Rance, Kevin Marsh, Peter C. Bull, Abdirahman I. Abdi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
In sub-Saharan Africa, children below 5 years bear the greatest burden of severe malaria because they lack naturally acquired immunity that develops following repeated exposure to infections by Plasmodium falciparum. Antibodies to the surface of P. f
Externí odkaz:
https://doaj.org/article/74929df818d342d4bfa089b87a952e9a
Autor:
Qingqing Jing, Long Cao, Liangliang Zhang, Xiu Cheng, Nicolas Gilbert, Xueyu Dai, Maoxin Sun, Shaohui Liang, Lubin Jiang
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Plasmodium falciparum erythrocyte membrane protein 1, encoded by var gene, is an immunodominant antigen mediating immune evasion in humans. At a given time, only a single var gene is commonly expressed in one parasite. However, the regulation mechani
Externí odkaz:
https://doaj.org/article/96b3ded0ab2042eeb48822faa47d2b48
Akademický článek
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