Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

Autor: van Doorn Ruben, Lopes Pinheiro Melissa A, Kooij Gijs, Lakeman Kim, van het Hof Bert, van der Pol Susanne MA, Geerts Dirk, van Horssen Jack, van der Valk Paul, van der Kam Elizabeth, Ronken Eric, Reijerkerk Arie, de Vries Helga E

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 133 (2012)

Abstract Background The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be re

Externí odkaz: https://doaj.org/article/9fa0c846591c43db9ef40d98cd3fcc0a

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner

Autor: Derada Troletti, Claudio, Lopes Pinheiro, Melissa A., Charabati, Marc, Gowing, Elizabeth, van het Hof, Bert, van der Pol, Susanne M.A., Geerts, Dirk, Prat, Alexandre, Fontijn, Ruud D., Unger, Wendy W., de Vries, Helga E.

Publikováno v: In Brain Behavior and Immunity March 2018 69:48-56

Specialized differentially pro-resolving altered in peripheral lipid mediators blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

Autor: Kooij, Gijs, Derada Troletti, Claudio, Leuti, Alessandro, Norris, Paul C, Riley, Ian, Albanese, Maria, Ruggieri, Serena, Libreros, Stephania, van der Pol, Susanne M A, van Het Hof, Bert, Schell, Yoëlle, Guerrera, Gisella, Buttari, Fabio, Mercuri, Nicola Biagio, Centonze, Diego, Gasperini, Claudio, Battistini, Luca, de Vries, Helga E, Serhan, Charles N, Chiurchiù, Valerio

Publikováno v: Haematologica, 105(8), 2056-2070. Ferrata Storti Foundation
Kooij, G, Derada Troletti, C, Leuti, A, Norris, P C, Riley, I, Albanese, M, Ruggieri, S, Libreros, S, van der Pol, S M A, van Het Hof, B, Schell, Y, Guerrera, G, Buttari, F, Mercuri, N B, Centonze, D, Gasperini, C, Battistini, L, de Vries, H E, Serhan, C N & Chiurchiù, V 2020, ' Specialized differentially pro-resolving altered in peripheral lipid mediators blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction ', Haematologica, vol. 105, no. 8, pp. 2056-2070 . https://doi.org/10.3324/haematol.2019.219519

Chronic inflammation is a key pathological hallmark of multiple sclerosis and suggests that resolution of inflammation, orchestrated by specialized pro-resolving lipid mediators, is impaired. Here, through targeted-metabololipidomics in peripheral bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5b06914a14fdf2655d6cacd879496d14
https://research.vumc.nl/en/publications/be2eb9e6-09f1-4823-a458-eb861f27d428

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