Interstitial flow potentiates TGF-β/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip.

Autor: Rahman Z; Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl., Bordoloi AD; Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl., Rouhana H; Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl., Tavasso M; Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl., van der Zon G; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands., Garbin V; Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl., Ten Dijke P; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands., Boukany PE; Department of Chemical Engineering, Delft University of Technology, Delft, The Netherlands. p.e.boukany@tudelft.nl.

Publikováno v: Lab on a chip [Lab Chip] 2024 Jan 30; Vol. 24 (3), pp. 422-433. Date of Electronic Publication: 2024 Jan 30.

OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor.

Autor: Fan C; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Wang Q; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., van der Zon G; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Ren J; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Agaser C; Department of Biomedical Data Sciences, Sequencing Analysis Support Core, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Slieker RC; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.; Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, location VUmc, Amsterdam, 1081 HV, The Netherlands., Iyengar PV; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Mei H; Department of Biomedical Data Sciences, Sequencing Analysis Support Core, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Ten Dijke P; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands. p.ten_dijke@lumc.nl.; Oncode Institute, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands. p.ten_dijke@lumc.nl.

Publikováno v: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2022 Apr 29; Vol. 7 (1), pp. 126. Date of Electronic Publication: 2022 Apr 29.

Kaempferide Inhibits DOX-induced Liver Inflammation by Activating AMPKα/SIRT1.

Autor: Li, Qiang¹ (AUTHOR), Li, Xing¹ (AUTHOR), Zhou, Zhenchang¹ (AUTHOR), Zhu, Pingwei¹ (AUTHOR), Tuo, Nana¹ (AUTHOR), Ge, Jingli¹ (AUTHOR), Liu, Zhaoyv¹ (AUTHOR), Chen, Dengke¹ (AUTHOR) alcm4055@sina.com

Publikováno v: Pharmacognosy Magazine. Dec2024, Vol. 20 Issue 4, p1304-1312. 9p.

TGF-β-Induced Endothelial to Mesenchymal Transition Is Determined by a Balance Between SNAIL and ID Factors.

Autor: Ma J; Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, Netherlands., van der Zon G; Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, Netherlands., Gonçalves MAFV; Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands., van Dinther M; Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, Netherlands., Thorikay M; Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, Netherlands., Sanchez-Duffhues G; Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands., Ten Dijke P; Department of Cell Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.; Oncode Institute, Leiden University Medical Center, Leiden, Netherlands.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Feb 12; Vol. 9, pp. 616610. Date of Electronic Publication: 2021 Feb 12 (Print Publication: 2021).

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells.

Autor: Zhang J; Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center., Thorikay M; Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center., van der Zon G; Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center., van Dinther M; Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center., Ten Dijke P; Oncode Institute and Department of Cell Chemical Biology, Leiden University Medical Center; p.ten_dijke@lumc.nl.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2020 Oct 27 (164). Date of Electronic Publication: 2020 Oct 27.