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Characterization of monoclonal antibody charge variants under near-native separation conditions using nanoflow sheath liquid capillary electrophoresis-mass spectrometry.

Autor: van der Zon AAM; University of Amsterdam, van 't Hoff Institute for Molecular Sciences, Analytical Chemistry Group, Science Park 904, 1098 XH, Amsterdam, the Netherlands; Centre of Analytical Sciences Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands. Electronic address: a.a.m.vanderzon@uva.nl., Höchsmann A; Aalen University, Department of Chemistry, Beethovenstraße 1, 73430, Aalen, Germany; Eberhard Karls University of Tübingen, Faculty of Science, 72074, Tübingen, Germany., Bos TS; University of Amsterdam, van 't Hoff Institute for Molecular Sciences, Analytical Chemistry Group, Science Park 904, 1098 XH, Amsterdam, the Netherlands; Centre of Analytical Sciences Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands., Neusüß C; Aalen University, Department of Chemistry, Beethovenstraße 1, 73430, Aalen, Germany., Somsen GW; Centre of Analytical Sciences Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands; Vrije Universiteit Amsterdam, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands., Jooß K; Centre of Analytical Sciences Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands; Vrije Universiteit Amsterdam, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands. Electronic address: k.jooss@vu.nl., Haselberg R; Centre of Analytical Sciences Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands; Vrije Universiteit Amsterdam, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands. Electronic address: rob.haselberg@vectorytx.com., Gargano AFG; University of Amsterdam, van 't Hoff Institute for Molecular Sciences, Analytical Chemistry Group, Science Park 904, 1098 XH, Amsterdam, the Netherlands; Centre of Analytical Sciences Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands. Electronic address: a.gargano@uva.nl.

Publikováno v: Analytica chimica acta [Anal Chim Acta] 2024 Dec 01; Vol. 1331, pp. 343287. Date of Electronic Publication: 2024 Oct 09.