Salivary polyreactive antibodies and Haemophilus influenzae are associated with respiratory infection severity in young children with recurrent respiratory infections.

Autor: Koenen MH; Center for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands., de Steenhuijsen Piters WAA; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., de Jonge MI; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud Community for Infectious Diseases (RCI), Radboud University Medical Centre, Nijmegen, The Netherlands., Langereis JD; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud Community for Infectious Diseases (RCI), Radboud University Medical Centre, Nijmegen, The Netherlands., Nierkens S; Center for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Chu MLJN; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van der Woude R; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., de Vries RP; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Sanders EAM; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Bogaert D; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., van der Vries E; Department of Research and Development, GD Animal Health, Deventer, The Netherlands.; Department of Clinical Chemistry and Haematology, UMC Utrecht, Utrecht, The Netherlands., Boes M; Center for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands., Verhagen LM; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, The Netherlands lilly.verhagen@radboudumc.nl.; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud Community for Infectious Diseases (RCI), Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, The Netherlands.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Oct 03; Vol. 64 (4). Date of Electronic Publication: 2024 Oct 03 (Print Publication: 2024).

Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling.

Autor: Unione L; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands. lunione@cicbiogune.es.; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Bizkaia, Spain. lunione@cicbiogune.es.; Ikerbasque, Basque Foundation for Science, Euskadi Plaza 5, 48009, Bilbao, Bizkaia, Spain. lunione@cicbiogune.es., Ammerlaan ANA; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Bosman GP; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Uslu E; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Liang R; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Broszeit F; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., van der Woude R; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Liu Y; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Ma S; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, GA, 30602, USA., Liu L; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, GA, 30602, USA., Gómez-Redondo M; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Bizkaia, Spain., Bermejo IA; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Bizkaia, Spain., Valverde P; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Bizkaia, Spain., Diercks T; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Bizkaia, Spain., Ardá A; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Bizkaia, Spain.; Ikerbasque, Basque Foundation for Science, Euskadi Plaza 5, 48009, Bilbao, Bizkaia, Spain., de Vries RP; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands. R.Vries@uu.nl., Boons GJ; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands. g.j.p.h.boons@uu.nl.; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, GA, 30602, USA. g.j.p.h.boons@uu.nl.; Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands. g.j.p.h.boons@uu.nl.; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA. g.j.p.h.boons@uu.nl.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 06; Vol. 15 (1), pp. 2979. Date of Electronic Publication: 2024 Apr 06.

Chemo-Enzymatic Synthesis of Isomeric I-branched Polylactosamines Using Traceless Blocking Groups.

Autor: Vos GM; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, Netherlands., Wu Y; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, Netherlands., van der Woude R; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, Netherlands., de Vries RP; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, Netherlands., Boons GJ; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, Netherlands.; Complex Carbohydrate Research Center, University of Georgia, Athens, GA-30602, USA.; Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands.; Chemistry Department, University of Georgia, Athens, GA-30602, USA.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jan 22; Vol. 30 (5), pp. e202302877. Date of Electronic Publication: 2023 Dec 04.

SARS-CoV-2 Spike N-Terminal Domain Engages 9- O -Acetylated α2-8-Linked Sialic Acids.

Autor: Tomris I; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Unione L; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Bizkaia, Spain.; Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Bizkaia, Spain., Nguyen L; Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton T6G 2G2, Canada., Zaree P; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Bouwman KM; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Liu L; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, United States., Li Z; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Fok JA; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Ríos Carrasco M; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., van der Woude R; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Kimpel ALM; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Linthorst MW; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Kilavuzoglu SE; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Verpalen ECJM; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Caniels TG; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1081 HZ Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, 1081 HZ Amsterdam, The Netherlands., Sanders RW; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, 1081 HZ Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, 1081 HZ Amsterdam, The Netherlands.; Department of Microbiology and Immunology, Weill Medical Center of Cornell University, 1300 York Avenue, New York, New York 10065, United States., Heesters BA; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Pieters RJ; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Jiménez-Barbero J; CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Bizkaia, Spain.; Department of Microbiology and Immunology, Weill Medical Center of Cornell University, 1300 York Avenue, New York, New York 10065, United States.; Department of Organic Chemistry, II Faculty of Science and Technology University of the Basque Country, EHU-UPV, 48940 Leioa, Spain.; Centro de Investigación Biomédica En Red de Enfermedades Respiratorias, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain., Klassen JS; Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton T6G 2G2, Canada., Boons GJ; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, United States., de Vries RP; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2023 May 19; Vol. 18 (5), pp. 1180-1191. Date of Electronic Publication: 2023 Apr 27.

Facile electrochemical affinity measurements of small and large molecules.

Autor: Zaree P; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University P. O. Box 80082 NL-3508 TB Utrecht The Netherlands R.J.Pieters@uu.nl., Tomris I; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University P. O. Box 80082 NL-3508 TB Utrecht The Netherlands R.J.Pieters@uu.nl., de Vos SD; Institute for Sustainable and Circular Chemistry, Debye Institute for Nanomaterials Science, Utrecht University Universiteitsweg 99 3584 CG Utrecht The Netherlands., van der Woude R; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University P. O. Box 80082 NL-3508 TB Utrecht The Netherlands R.J.Pieters@uu.nl., Flesch FM; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University P. O. Box 80082 NL-3508 TB Utrecht The Netherlands R.J.Pieters@uu.nl., Klein Gebbink RJM; Institute for Sustainable and Circular Chemistry, Debye Institute for Nanomaterials Science, Utrecht University Universiteitsweg 99 3584 CG Utrecht The Netherlands., de Vries RP; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University P. O. Box 80082 NL-3508 TB Utrecht The Netherlands R.J.Pieters@uu.nl., Pieters RJ; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University P. O. Box 80082 NL-3508 TB Utrecht The Netherlands R.J.Pieters@uu.nl.

Publikováno v: RSC advances [RSC Adv] 2023 Mar 27; Vol. 13 (14), pp. 9756-9760. Date of Electronic Publication: 2023 Mar 27 (Print Publication: 2023).