Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates

Autor: Backus, H H, Pinedo, H M, Wouters, D, Padrón, J M, Molders, N, van Der Wilt, C L, van Groeningen, C J, Jansen, G, Peters, G J

Publikováno v: Backus, H H, Pinedo, H M, Wouters, D, Padrón, J M, Molders, N, van Der Wilt, C L, van Groeningen, C J, Jansen, G & Peters, G J 2000, ' Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates ', International Journal of Cancer, vol. 87, no. 6, pp. 771-8 .
International Journal of Cancer, 87(6), 771-8. Wiley-Liss Inc.

Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environment with relatively high folate (HF) levels, compared with folate levels in human plasma. In the present study we adapted 4 colon cancer (C26-A, C26-10

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https://research.vumc.nl/en/publications/05630a4a-e8e6-46a3-9403-792c594b3e2b

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