Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation.

Autor: Saager ES; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands., van Stigt AH; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands., Lerkvaleekul B; Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Lutter L; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands.; Department of Pathology, Amsterdam University Medical Centre, Amsterdam, Netherlands., Hellinga AH; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands., van der Wal MM; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands., Bont LJ; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands.; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, Netherlands.; ReSViNET foundation, Zeist, Netherlands., Leusen JH; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands., Van't Land B; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands.; CoE Immunology, Danone Global Research & Innovation Center, Utrecht, Netherlands., van Wijk F; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands.

Publikováno v: JCI insight [JCI Insight] 2024 Sep 03; Vol. 9 (20). Date of Electronic Publication: 2024 Sep 03.

Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration.

Autor: Muffels IJJ; Department of Metabolic Diseases, Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, the Netherlands; Center for Translational Immunology (CTI), Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Schene IF; Department of Metabolic Diseases, Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, the Netherlands., Rehmann H; Department of Energy and Biotechnology, Flensburg University of Applied Sciences, Flensburg, Germany., Massink MPG; Department of Genetics, Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van der Wal MM; Center for Translational Immunology (CTI), Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bauder C; Department of Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, Munich, Germany., Labeur M; Department of Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany., Armando NG; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires, Argentina., Lequin MH; Division Imaging and Oncology University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Houben ML; Department of General Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Giltay JC; Department of Genetics, Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Haitjema S; Central Diagnostics Laboratory, University Medical Center Utrecht, Utrecht, the Netherlands., Huisman A; Central Diagnostics Laboratory, University Medical Center Utrecht, Utrecht, the Netherlands., Vansenne F; Department of Medical Genetics, University Medical Center Groningen, Groningen, the Netherlands., Bluvstein J; Dravet Center and Comprehensive Epilepsy Center, NYU School of Medicine, New York, NY, USA., Pappas J; NYU Clinical Genetic Services, NYU Grossman School of Medicine, New York, NY, USA., Shailee LV; Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA., Zarate YA; Section of Genetics and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Mokry M; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands., van Haaften GW; Department of Genetics, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands., Nieuwenhuis EES; Department of Biomedical and Life Sciences, University College Roosevelt, Middelburg, the Netherlands., Refojo D; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires, Argentina; Molecular Neurobiology, Max Planck Institute of Psychiatry, Munich, Germany., van Wijk F; Department of Genetics, Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fuchs SA; Department of Metabolic Diseases, Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, the Netherlands., van Hasselt PM; Department of Metabolic Diseases, Division Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, the Netherlands. Electronic address: p.vanhasselt@umcutrecht.nl.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2023 Jan 05; Vol. 110 (1), pp. 146-160.

Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint.

Autor: Lutter L; Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands.; Department of Gastroenterology and Hepatology, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands., van der Wal MM; Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands., Brand EC; Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands.; Department of Gastroenterology and Hepatology, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands., Maschmeyer P; Therapeutic Gene Regulation Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association Berlin Germany., Vastert S; Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands., Mashreghi MF; Therapeutic Gene Regulation Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association Berlin Germany.; BIH Center for Regenerative Therapies (BCRT) Berlin Institute of Health at Charité - Universitätsmedizin Berlin Charitéplatz 1 Berlin Germany., van Loosdregt J; Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands., van Wijk F; Center for Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht Utrecht University Utrecht The Netherlands.

Publikováno v: Clinical & translational immunology [Clin Transl Immunology] 2022 Sep 30; Vol. 11 (10), pp. e1420. Date of Electronic Publication: 2022 Sep 30 (Print Publication: 2022).

Siglec-1 expression on monocytes is associated with the interferon signature in juvenile dermatomyositis and can predict treatment response.

Autor: Lerkvaleekul B; Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht., Veldkamp SR; Center for Translational Immunology, University Medical Center Utrecht, Utrecht., van der Wal MM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht., Schatorjé EJH; Department of Paediatrics, Paediatric Rheumatology, Amalia Children's Hospital, Radboud University Medical Centre Nijmegen, Nijmegen., Kamphuis SSM; Paediatric Rheumatology, Sophia Children's Hospital, Erasmus University Medical Centre, Rotterdam., van den Berg JM; Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam., Hissink Muller PCE; Department of Paediatric Rheumatology, Leiden University Medical Centre, Leiden., Armbrust W; Department of Pediatric Rheumatology and Immunology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen., Vastert SJ; Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands., Wienke J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht., Jansen MHA; Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands., van Royen-Kerkhof A; Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands., van Wijk F; Center for Translational Immunology, University Medical Center Utrecht, Utrecht.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 May 05; Vol. 61 (5), pp. 2144-2155.

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis.

Autor: Bakker DS; National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., van der Wal MM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Heeb LEM; Department of Immunology, University Hospital Zurich, Zurich, Switzerland., Giovannone B; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Asamoah M; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Delemarre EM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Drylewicz J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Nierkens S; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Boyman O; Department of Immunology, University Hospital Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, Switzerland., de Bruin-Weller MS; National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands., Thijs JL; National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., van Wijk F; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: F.vanWijk@umcutrecht.nl.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2021 Aug; Vol. 141 (8), pp. 1943-1953.e13. Date of Electronic Publication: 2021 Feb 18.