Gut microbiota promotes arterial thrombus formation in hyperlipidemic Ldlr-/- mouse model

Autor: Khuu, MP, Kiouptsi, K, Pontarollo, G, van der Vorst, EPC, Döring, Y, Müller, M, Schäfer, K, Reinhardt, C

Publikováno v: Hämostaseologie; February 2023, Vol. 43 Issue: 1, Number 1 Supplement 1

Pneumonia Induced Rise in Glucagon Promotes Endothelial Damage and Thrombogenicity.

Autor: Ramezani Rad P; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.)., Nageswaran V; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Friede Springer-Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Germany (V.N., U.L., A.H.).; Institute of Chemistry and Biochemistry (V.N.), Freie Universität Berlin, Germany.; Department of Cardiology, University Hospital St Josef-Hospital Bochum, Ruhr University Bochum, Germany (V.N., L.R., J.R., A.H.)., Peters L; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Institute of Biology (L.P.), Freie Universität Berlin, Germany.; Institute of Physiology (L.P., S.S., E.A., W.M.K.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany., Reinshagen L; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Department of Cardiology, University Hospital St Josef-Hospital Bochum, Ruhr University Bochum, Germany (V.N., L.R., J.R., A.H.)., Roessler J; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Department of Cardiology, University Hospital St Josef-Hospital Bochum, Ruhr University Bochum, Germany (V.N., L.R., J.R., A.H.)., Simmons S; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Institute of Physiology (L.P., S.S., E.A., W.M.K.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany., Asmus E; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; Institute of Physiology (L.P., S.S., E.A., W.M.K.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany., Wittig C; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Laboratory of In Vitro Modeling Systems of Pulmonary and Thrombotic Diseases, Institute of Physiology (C.W., R.S.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.; German Center for Lung Research (DZL), Germany (C.W., R.S., M.W., W.M.K.)., Brack MC; Department of Infectious Diseases, Respiratory Medicine and Critical Care (M.C.B., G.N., M.W.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany., Nouailles G; Department of Infectious Diseases, Respiratory Medicine and Critical Care (M.C.B., G.N., M.W.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany., van der Vorst EPC; Institute for Molecular Cardiovascular Research (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany.; Aachen-Maastricht Institute for CardioRenal Disease (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany.; Interdisciplinary Center for Clinical Research (E.P.C.v.d.V.), RWTH Aachen University, Germany.; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Germany (E.P.C.v.d.V.)., Maas SL; Institute for Molecular Cardiovascular Research (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany.; Aachen-Maastricht Institute for CardioRenal Disease (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany., Sonnenschein K; Department of Cardiology and Angiology (K.S.), Hannover Medical School, Germany.; Institute of Molecular and Translational Therapeutic Strategies (K.S.), Hannover Medical School, Germany., Verhaar BJH; Department of Vascular Medicine (B.J.H.V.), Amsterdam University Medical Centers, the Netherlands.; Department of Public and Occupational Health (B.J.H.V.), Amsterdam University Medical Centers, the Netherlands., Szulcek R; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Laboratory of In Vitro Modeling Systems of Pulmonary and Thrombotic Diseases, Institute of Physiology (C.W., R.S.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.; German Center for Lung Research (DZL), Germany (C.W., R.S., M.W., W.M.K.)., Witzenrath M; Department of Infectious Diseases, Respiratory Medicine and Critical Care (M.C.B., G.N., M.W.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.; German Center for Lung Research (DZL), Germany (C.W., R.S., M.W., W.M.K.)., Landmesser U; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Friede Springer-Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Germany (V.N., U.L., A.H.)., Kuebler WM; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Institute of Physiology (L.P., S.S., E.A., W.M.K.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.; German Center for Lung Research (DZL), Germany (C.W., R.S., M.W., W.M.K.).; The Keenan Research Centre for Biomedical Science at St. Michael's, Toronto, Canada (W.M.K.).; Departments of Surgery and Physiology, University of Toronto, Canada (W.M.K.)., Haghikia A; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).; German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).; Friede Springer-Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Germany (V.N., U.L., A.H.).; Department of Cardiology, University Hospital St Josef-Hospital Bochum, Ruhr University Bochum, Germany (V.N., L.R., J.R., A.H.).

Publikováno v: Circulation research [Circ Res] 2024 Nov 08; Vol. 135 (11), pp. 1116-1118. Date of Electronic Publication: 2024 Oct 01.

(Multi-) omics studies of ILC2s in inflammation and metabolic diseases.

Autor: Kral M; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., van der Vorst EPC; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University Munich, Munich, Germany.; Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), Interdisciplinary Center for Clinical Research (IZKF), Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany., Weber C; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Netherlands.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Döring Y; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research (DBMR), University Hospital, University of Bern, Bern, Switzerland.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Oct 28; Vol. 12, pp. 1473616. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024).

Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.

Autor: Wang Y; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Li G; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Chen B; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Shakir G; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Volz M; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., van der Vorst EPC; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany.; Institute for Molecular Cardiovascular Research (IMCAR), Aachen-Maastricht Institute for CardioRenal Disease (AMICARE) and Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany., Maas SL; Institute for Molecular Cardiovascular Research (IMCAR), Aachen-Maastricht Institute for CardioRenal Disease (AMICARE) and Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany., Geiger M; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Jethwa C; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Bartelt A; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany.; DZHK (German Center for Cardiovasular Research), partner site Munich Heart Alliance, Pettenkoferstr. 9, 80336 Munich, Germany.; Institute for Diabetes and Cancer, Helmholtz Zentrum Munich, Neuherberg, Germany.; Department of Molecular Metabolism & Sabri Ülker Center for Metabolic Research, Harvard T.H. Chan School of Public Health, Boston, USA., Li Z; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar-Technical University Munich (TUM), Munich, Germany., Wettich J; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar-Technical University Munich (TUM), Munich, Germany., Sachs N; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar-Technical University Munich (TUM), Munich, Germany., Maegdefessel L; DZHK (German Center for Cardiovasular Research), partner site Munich Heart Alliance, Pettenkoferstr. 9, 80336 Munich, Germany.; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar-Technical University Munich (TUM), Munich, Germany., Nazari Jahantigh M; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Hristov M; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Lacy M; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Lutz B; Institute of Physiological Chemistry, University Medical Center, Mainz, Germany., Weber C; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany.; DZHK (German Center for Cardiovasular Research), partner site Munich Heart Alliance, Pettenkoferstr. 9, 80336 Munich, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, 6229 ER Maastricht, The Netherlands.; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Straße 17, 81377 Munich, Germany., Herzig S; DZHK (German Center for Cardiovasular Research), partner site Munich Heart Alliance, Pettenkoferstr. 9, 80336 Munich, Germany.; Institute for Diabetes and Cancer, Helmholtz Zentrum Munich, Neuherberg, Germany.; Chair Molecular Metabolic Control, TU Munich, Ismaninger Str. 22, 81675 Munich, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany., Guillamat Prats R; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany., Steffens S; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9, 80336 Munich, Germany.; DZHK (German Center for Cardiovasular Research), partner site Munich Heart Alliance, Pettenkoferstr. 9, 80336 Munich, Germany.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2024 Oct 14; Vol. 120 (12), pp. 1411-1426.

Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells.

Autor: Lin C; Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.; Department of Rheumatology and Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Jans A; Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany., Wolters JC; Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen, 9713 AV, The Netherlands., Mohamed MR; Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany., Van der Vorst EPC; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074, Aachen, Germany.; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074, Aachen, Germany.; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, 80336, Munich, Germany., Trautwein C; Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany., Bartneck M; Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2024 Oct; Vol. 13 (26), pp. e2202670. Date of Electronic Publication: 2023 Jan 08.