Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies.

Autor: Zitzmann C; Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany.; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America., Dächert C; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany., Schmid B; Dept of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany., van der Schaar H; Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands., van Hemert M; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Perelson AS; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America., van Kuppeveld FJM; Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands., Bartenschlager R; Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.; Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Center for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany., Binder M; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany., Kaderali L; Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2023 Apr 04; Vol. 19 (4), pp. e1010423. Date of Electronic Publication: 2023 Apr 04 (Print Publication: 2023).

The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles

Autor: Melia, C E, van der Schaar, H M, de Jong, A W M, Lyoo, H R, Snijder, Eric J, Koster, A J, van Kuppeveld, F J M, Bárcena, Montserrat, dI&I I&I-1, LS Virologie, Environmental Sciences

Publikováno v: mBio
mBio, Vol 9, Iss 2 (2018)
mBio, 9(2). American Society for Microbiology
mBio, 9(2)
mBio, Vol 9, Iss 2, p e00420-18 (2018)

Picornaviruses induce dramatic rearrangements of endomembranes in the cells that they infect to produce dedicated platforms for viral replication. These structures, termed replication organelles (ROs), have been well characterized for the Enterovirus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac55183c90bbd18f7a27b6024dfa997e
https://doi.org/10.1128/mbio.00420-18

From the "One-Molecule, One-Target, One-Disease" Concept towards Looking for Multi-Target Therapeutics for Treating Non-Polio Enterovirus (NPEV) Infections.

Autor: Roux, Hugo¹ (AUTHOR) hugo.roux@univ-amu.fr, Touret, Franck² (AUTHOR) franck.touret@univ-amu.fr, Rathelot, Pascal¹ (AUTHOR) pascal.rathelot@univ-amu.fr, Vanelle, Patrice¹ (AUTHOR) patrice.vanelle@univ-amu.fr, Roche, Manon¹ (AUTHOR) patrice.vanelle@univ-amu.fr

Publikováno v: Pharmaceuticals (14248247). Sep2024, Vol. 17 Issue 9, p1218. 41p.

Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis.

Autor: Ng, Qing Yong^1,2 (AUTHOR), Mahendran, Vikneswari^1,2 (AUTHOR), Lim, Ze Qin^1,2 (AUTHOR), Tan, Jasmine Hwee Yee^1,2 (AUTHOR), Wong, Joel Jie Feng^1,2 (AUTHOR), Chu, Justin Jang Hann¹ (AUTHOR), Chow, Vincent T. K.¹ (AUTHOR), Sze, Newman Siu Kwan^3,4 (AUTHOR), Alonso, Sylvie^1,2 (AUTHOR) micas@nus.edu.sg

Publikováno v: Journal of Biomedical Science. 6/28/2024, Vol. 31 Issue 1, p1-21. 21p.

Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity.

Autor: Cedillo-Barrón, Leticia¹ (AUTHOR) jugarcia@cinvestav.mx, García-Cordero, Julio¹ (AUTHOR) giovani.visoso@cinvestav.mx, Visoso-Carvajal, Giovani^1,2 (AUTHOR), León-Juárez, Moisés³ (AUTHOR) moisesleoninper@gmail.com

Publikováno v: Viruses (1999-4915). Mar024, Vol. 16 Issue 3, p345. 16p.