The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme.

Autor: Sbornova, Irina¹ (AUTHOR) pdas1@umbc.edu, van der Sande, Emilie^2,3,4 (AUTHOR), Milosavljevic, Snezana⁵ (AUTHOR), Amurrio, Elvis¹ (AUTHOR) janvipatel@som.umaryland.edu, Burbano, Steven D.¹ (AUTHOR), Das, Prosun K.¹ (AUTHOR), Do, Helen H.¹ (AUTHOR), Fisher, Janet L.⁵ (AUTHOR), Kargbo, Porschderek¹ (AUTHOR), Patel, Janvi¹ (AUTHOR), Porcher, Latarsha¹ (AUTHOR), De Zeeuw, Chris I.^4,6 (AUTHOR), Meester-Smoor, Magda A.^2,3 (AUTHOR), Winkelman, Beerend H. J.^2,3,4,6 (AUTHOR), Klaver, Caroline C. W.^2,3,7,8 (AUTHOR), Pocivavsek, Ana⁵ (AUTHOR), Kelly, Michy P.^1,9 (AUTHOR) michy.kelly@som.umaryland.edu

Publikováno v: Cells (2073-4409). Dec2023, Vol. 12 Issue 24, p2839. 26p.

Functional myopia studies in mice

Autor: van der Sande, Emilie

Functional validation of candidate genes of myopia (nearsightedness) in mouse models, and the exploration of high dose atropine eye drops for the treatment of Mendelian myopia in children and mice.

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https://pure.eur.nl/en/publications/ba46154b-4ab8-401a-9abc-ca7b23769a85

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The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme.

Autor: Sbornova I; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., van der Sande E; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; The Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Art & Science (KNAW), Meibergdreef 47, Amsterdam, The Netherlands., Milosavljevic S; Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC., Amurrio E; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Burbano SD; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Das P; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Do H; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Fisher JL; Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC., Kargbo P; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Patel J; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., Porcher L; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201., De Zeeuw CI; The Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Art & Science (KNAW), Meibergdreef 47, Amsterdam, The Netherlands.; Department of Neuroscience, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands., Meester-Smoor MA; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands., Winkelman BHJ; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; The Netherlands Institute for Neuroscience (NIN), Royal Dutch Academy of Art & Science (KNAW), Meibergdreef 47, Amsterdam, The Netherlands.; Department of Neuroscience, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands., Klaver CCW; Department of Ophthalmology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Wytemaweg 40, Rotterdam, The Netherlands.; Department of Ophthalmology, Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen, The Netherlands.; Institute of Molecular and Clinical Ophthalmology, Mittlere Strasse 91, Basel, Switzerland., Pocivavsek A; Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Garners Ferry Rd, Columbia, SC., Kelly MP; Department of Anatomy & Neurobiology, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.; Center for Research on Aging, University of Maryland School of Medicine, 20 Penn St, Baltimore, MD 21201.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 17. Date of Electronic Publication: 2023 Nov 17.