Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A

Autor: van der Plaat, DA, de Jong, K, Lahousse, L, Faiz, A, Vonk, JM, van Diemen, CC, Nedeljkovic, I, Amin, N, Brusselle, GG, Hofman, A, Brandsma, C-A, Bossé, Y, Sin, DD, Nickle, DC, van Duijn, CM, Postma, DS, Boezen, HM

BACKGROUND: Although a striking proportion (25% to 45%) of patients with chronic obstructive pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this group exclusively. OBJECTIVE: The aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::a1d92e46b874f12e52f4a655f5c1b296
https://hdl.handle.net/10453/160198

SNPs in FAM13A and IL2RB genes are associated with FeNO in adult subjects with asthma.

Autor: Accordini S; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona 37134, Italy., Lando V; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona 37134, Italy., Calciano L; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona 37134, Italy., Bombieri C; Biology and Genetics Section, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy., Malerba G; Biology and Genetics Section, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy., Margagliotti A; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona 37134, Italy., Minelli C; National Heart and Lung Institute, Imperial College London, London SW3 6LR, United Kingdom., Potts J; National Heart and Lung Institute, Imperial College London, London SW3 6LR, United Kingdom., van der Plaat DA; National Heart and Lung Institute, Imperial College London, London SW3 6LR, United Kingdom., Olivieri M; Retired Professor of Occupational Medicine, University of Verona, Verona, Italy.

Publikováno v: Journal of breath research [J Breath Res] 2023 Oct 06; Vol. 18 (1). Date of Electronic Publication: 2023 Oct 06.

Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.

Autor: Lee M; Epidemiology Branch., Huan T; Department of Ophthalmology, University of Massachusetts Medical School, Worcester, Massachusetts.; Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, Framingham, Massachusetts., McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer and., Chittoor G; Department of Population Health Sciences, Geisinger, Danville, Pennsylvania.; Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina., de Vries M; Department of Epidemiology.; Groningen Research Institute for Asthma and COPD, and., Lahousse L; Department of Bioanalysis, Ghent University, Ghent, Belgium.; Department of Epidemiology and., Nguyen JN; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia., Brody JA; Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine., Castillo-Fernandez J; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom., Terzikhan N; Department of Epidemiology and., Qi C; Groningen Research Institute for Asthma and COPD, and.; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Joehanes R; Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, Framingham, Massachusetts., Min JL; Medical Research Council Integrative Epidemiology Unit and.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Smilnak GJ; Epidemiology Branch., Shaw JR; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, and., Yang CX; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Colicino E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Hoang TT; Epidemiology Branch., Bermingham ML; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer and., Xu H; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Justice AE; Department of Population Health Sciences, Geisinger, Danville, Pennsylvania.; Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina., Xu CJ; Centre for Individualised Infection Medicine, a joint venture between Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.; Research Group Bioinformatics and Computational Genomics, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia., Cox SR; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom., Vonk JM; Department of Epidemiology.; Groningen Research Institute for Asthma and COPD, and., Prokić I; Department of Epidemiology and., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, Department of Epidemiology., Tsai PC; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.; Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan., Schwartz JD; Department of Environmental Health and.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.; Channing Laboratory, Harvard Medical School, Boston, Massachusetts., Leung JM; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Sikdar S; Epidemiology Branch.; Department of Mathematics and Statistics, Old Dominion University, Norfolk, Virginia., Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer and., Harris SE; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom., van der Plaat DA; Department of Epidemiology.; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Van Den Berg DJ; Department of Preventive Medicine and.; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California., Bartz TM; Cardiovascular Health Research Unit, Department of Biostatistics., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom., Vokonas PS; Veterans Affairs Boston Healthcare System, School of Medicine and School of Public Health, Boston University, Boston, Massachusetts., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer and., Taylor AM; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom., Liu Y; Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina., Barr RG; Department of Medicine and.; Department of Epidemiology, Columbia University Medical Center, New York, New York., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, and.; Department of Epidemiology, University of Colorado, Aurora, Colorado., Baccarelli AA; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York., Obeidat M; Centre for Heart Lung Innovation, The University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, and.; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas., Wang T; Integrative Bioinformatics Support Group, and., Ward JM; Integrative Bioinformatics Support Group, and., Motsinger-Reif AA; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina., Hemani G; Medical Research Council Integrative Epidemiology Unit and.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Koppelman GH; Groningen Research Institute for Asthma and COPD, and.; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bell JT; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom., Gharib SA; Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine.; Computational Medicine Core, Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington., Brusselle G; Department of Epidemiology and.; Department of Respiratory Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; and., Boezen HM; Department of Epidemiology.; Groningen Research Institute for Asthma and COPD, and., North KE; Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina., Levy D; Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, Framingham, Massachusetts., Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer and., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Breeze CE; Altius Institute for Biomedical Sciences, Seattle, Washington., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia., London SJ; Epidemiology Branch.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2022 Aug 01; Vol. 206 (3), pp. 321-336.

Changing patterns of sickness absence among healthcare workers in England during the COVID-19 pandemic.

Autor: Edge R; Lancaster Medical School, Lancaster University, Lancaster, UK., van der Plaat DA; National Heart and Lung Institute (NHLI), Imperial College London, London, UK., Parsons V; Occupational Health Service, Guy's and St Thomas' NHS Foundation Trust, London, UK.; Faculty of Life Sciences and Medicine, King's College London, London, UK., Coggon D; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., van Tongeren M; School of Health Sciences, Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK., Muiry R; Occupational Health Service, Guy's and St Thomas' NHS Foundation Trust, London, UK., Madan I; Occupational Health Service, Guy's and St Thomas' NHS Foundation Trust, London, UK.; Faculty of Life Sciences and Medicine, King's College London, London, UK., Cullinan P; National Heart and Lung Institute (NHLI), Imperial College London, London, UK.

Publikováno v: Journal of public health (Oxford, England) [J Public Health (Oxf)] 2022 Mar 07; Vol. 44 (1), pp. e42-e50.

The use of two-sample methods for Mendelian randomization analyses on single large datasets.

Autor: Minelli C; National Heart and Lung Institute, Imperial College London, London, UK., Del Greco M F; Institute for Biomedicine, Eurac Research, Bolzano, Italy., van der Plaat DA; National Heart and Lung Institute, Imperial College London, London, UK., Bowden J; Medical School, University of Exeter, Exeter, UK., Sheehan NA; Department of Health Sciences, University of Leicester, Leicester, UK., Thompson J; Department of Health Sciences, University of Leicester, Leicester, UK.

Publikováno v: International journal of epidemiology [Int J Epidemiol] 2021 Nov 10; Vol. 50 (5), pp. 1651-1659.