Zobrazeno 1 - 10
of 212
pro vyhledávání: '"van der Merwe, PA"'
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in the RBD are present in SARS-CoV-2 variants of concern that have emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9653066755ada77b28aecd364d5c4207
https://doi.org/10.7554/elife.70658
https://doi.org/10.7554/elife.70658
Autor:
Van Der Merwe, PA
The recent discovery of tumour necrosis factor has been a major advance in the understanding of the biology of the immunological system. A review of this macrophage-secreted polypeptide hormone may be of special interest to clinicians because it appe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4861af7d5648ed4fd76840b96a2d2e2e
https://ora.ox.ac.uk/objects/uuid:cb057faa-1e95-4170-98ec-29a019bd7248
https://ora.ox.ac.uk/objects/uuid:cb057faa-1e95-4170-98ec-29a019bd7248
Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and recruitment of cytoplasmic signaling proteins. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ae2aab12a5706d0586d36ce9cba4f656
https://ora.ox.ac.uk/objects/uuid:ea26fbe4-3aa4-466b-ad45-4f89bcabd0df
https://ora.ox.ac.uk/objects/uuid:ea26fbe4-3aa4-466b-ad45-4f89bcabd0df
Autor:
Harkiolaki, M, Holmes, SL, Svendsen, P, Gregersen, JW, Jensen, LT, McMahon, R, Friese, MA, van Boxel, G, Etzensperger, R, Tzartos, JS, Kranc, K, Sainsbury, S, Harlos, K, Mellins, ED, Palace, J, Esiri, MM, van der Merwe, PA, Jones, EY, Fugger, L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ca2a099bf71d2a68749929e875ce74bf
https://ora.ox.ac.uk/objects/uuid:3ff3b88d-991e-4f1a-88e9-1ed073ea3e14
https://ora.ox.ac.uk/objects/uuid:3ff3b88d-991e-4f1a-88e9-1ed073ea3e14
The effect of SV40 viral transformation of human fibroblasts on intercellular gap junctional communication (IJC) was investigated using a short-term quantitative assay. IJC was measured using metabolic cooperation in a coculture system of argininosuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a4849196bd58311379d49c3016a838bc
https://ora.ox.ac.uk/objects/uuid:4794601e-453f-43ea-b01d-0b1deceedadd
https://ora.ox.ac.uk/objects/uuid:4794601e-453f-43ea-b01d-0b1deceedadd
Autor:
Dushek, O, Van der Merwe, PA
Publikováno v:
Trends in Immunology
Highlights • We propose that pMHC binding to TCR can increase (induce) pMHC rebinding. • Published studies are consistent with an induced rebinding model. • Induced rebinding improves the ability of T cells to discriminate antigens. • Induced
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https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bf1b417c6e254ff1d40939235613c643
https://ora.ox.ac.uk/objects/uuid:57cce6f4-9566-4d70-948d-a8d5e2e2e712
https://ora.ox.ac.uk/objects/uuid:57cce6f4-9566-4d70-948d-a8d5e2e2e712