Tertiary lymphoid structure formation: A matter of tumor-immune co-evolution.

Autor: van der Leun AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, USA; Broad Institute of MIT and Harvard, Cambridge, USA; Departments of Cell Biology and Pathology, Harvard Medical School, Boston, USA. Electronic address: anne_vanderleun@dfci.harvard.edu.

Publikováno v: Molecular immunology [Mol Immunol] 2024 Nov; Vol. 175, pp. 143-145. Date of Electronic Publication: 2024 Oct 09.

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma.

Autor: Vos JL; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Elbers JBW; Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands., Krijgsman O; Neogene Therapeutics, Amsterdam, The Netherlands., Traets JJH; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Qiao X; Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., van der Leun AM; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Lubeck Y; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Seignette IM; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Smit LA; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Willems SM; Department of Pathology and Medical Biology, Groningen University Medical Center, Groningen, The Netherlands., van den Brekel MWM; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Dirven R; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Baris Karakullukcu M; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Karssemakers L; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Klop WMC; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Lohuis PJFM; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Schreuder WH; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Smeele LE; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., van der Velden LA; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands., Bing Tan I; Department of Otorhinolaryngology Head and Neck Surgery, Maastricht University Medical Center+, Maastricht, The Netherlands., Onderwater S; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Jasperse B; Department of Radiology, Amsterdam University Medical Center location VUmc, Amsterdam, The Netherlands., Vogel WV; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Al-Mamgani A; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Keijser A; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, The Netherlands., van der Noort V; Department of Biometrics, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Broeks A; Core Facility Molecular Pathology & Biobanking, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Hooijberg E; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Peeper DS; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Schumacher TN; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Blank CU; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., de Boer JP; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Haanen JBAG; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Zuur CL; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. c.zuur@nki.nl.; Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. c.zuur@nki.nl.; Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center location AMC, Amsterdam, The Netherlands. c.zuur@nki.nl.; Department of Otorhinoloaryngology Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands. c.zuur@nki.nl.

Publikováno v: Nature communications [Nat Commun] 2021 Dec 22; Vol. 12 (1), pp. 7348. Date of Electronic Publication: 2021 Dec 22.

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag.

Autor: van der Leun AM; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Hoekstra ME; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Reinalda L; Department of Bio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., Scheele CLGJ; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.; VIB-KULeuven Center for Cancer Biology, Leuven, Belgium., Toebes M; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., van de Graaff MJ; Department of Bio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.; SeraNovo, Leiden, Netherlands., Chen LYY; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Li H; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Shenzhen Institute of Synthetic Biology, Shenzhen, China., Bercovich A; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel., Lubling Y; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel.; Cancer Research UK Cambridge Institute, Cambridge, UK., David E; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Thommen DS; Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands., Tanay A; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel., van Rheenen J; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Amit I; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., van Kasteren SI; Department of Bio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands. s.i.van.kasteren@chem.leidenuniv.nl., Schumacher TN; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands. t.schumacher@nki.nl.; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands. t.schumacher@nki.nl.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2021 Nov; Vol. 17 (11), pp. 1139-1147. Date of Electronic Publication: 2021 Sep 09.

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.

Autor: Li H, van der Leun AM, Yofe I, Lubling Y, Gelbard-Solodkin D, van Akkooi ACJ, van den Braber M, Rozeman EA, Haanen JBAG, Blank CU, Horlings HM, David E, Baran Y, Bercovich A, Lifshitz A, Schumacher TN, Tanay A, Amit I

Publikováno v: Cell [Cell] 2020 Apr 30; Vol. 181 (3), pp. 747.

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.

Autor: Li H; Department of Immunology, Weizmann Institute, Rehovot, Israel., van der Leun AM; Department of Molecular Oncology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands., Yofe I; Department of Immunology, Weizmann Institute, Rehovot, Israel., Lubling Y; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel., Gelbard-Solodkin D; Department of Immunology, Weizmann Institute, Rehovot, Israel., van Akkooi ACJ; Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands., van den Braber M; Department of Molecular Oncology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands., Rozeman EA; Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Medical Oncology Department, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands., Haanen JBAG; Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Medical Oncology Department, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands., Blank CU; Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Medical Oncology Department, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands., Horlings HM; Department of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands., David E; Department of Immunology, Weizmann Institute, Rehovot, Israel., Baran Y; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel., Bercovich A; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel., Lifshitz A; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel., Schumacher TN; Department of Molecular Oncology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: t.schumacher@nki.nl., Tanay A; Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel. Electronic address: amos.tanay@weizmann.ac.il., Amit I; Department of Immunology, Weizmann Institute, Rehovot, Israel. Electronic address: ido.amit@weizmann.ac.il.

Publikováno v: Cell [Cell] 2019 Feb 07; Vol. 176 (4), pp. 775-789.e18. Date of Electronic Publication: 2018 Dec 27.