Quantitative Image Analysis for Evaluating the Coating Thickness and Pore Distribution in Coated Small Particles

Autor: P. J. A. Hartman Kok, van der Kees Voort Maarschalk, Henderik W. Frijlink, F L Laksmana, Herman Vromans, L.J. van Vliet

Publikováno v: Pharmaceutical Research, 26 (4), 2009
Pharmaceutical Research, 26(4), 965-976. SPRINGER/PLENUM PUBLISHERS

Purpose This study aims to develop a characterization method for coating structure based on image analysis, which is particularly promising for the rational design of coated particles in the pharmaceutical industry. Methods The method applies the MAT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1530b0d978a1385cfc8fbd0e53aa5786
https://doi.org/10.1007/s11095-008-9805-y

Stress relaxation of compacts produced from viscoelastic materials

Autor: K. Zuurman, Lerk Coenraad, Gerad Klaas Bolhuis, Herman Vromans, van der Kees Voort Maarschalk

Publikováno v: International Journal of Pharmaceutics, 151(1), 27-34. Elsevier Bedrijfsinformatie b.v.

Stress relaxation of tablets is a phenomenon that is known to be related to elastic deformation of particles. Expressions of stress relaxation are tablet expansion and capping. It has been shown that there is a direct relation between the changes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bc06b29cfc23c47a49a59102b570ca
https://doi.org/10.1016/s0378-5173(97)04889-8

Gas permeation related to the moisture sorption in films of glassy hydrophilic polymers

Autor: van der Kees Voort Maarschalk, P. J. A. Hartman Kok, Henderik W. Frijlink, Herman Vromans, Fesia L. Laksmana

Publikováno v: Journal of Applied Polymer Science, 116(6), 3310-3317. Wiley

The purpose of this article is to elucidate the effect of integral sorption of moisture on gas permeation in glassy hydrophilic polymers. The oxygen and the simultaneous moisture sorption into various hydroxypropyl methylcellulose (HPMC) films were m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f242fd237944fbc9ba6d6635094028
https://doi.org/10.1002/app.31854

Milling of organic solids in a jet mill. Part 2: Checking the validity of the predicted rate of breakage function

Autor: van der Kees Voort Maarschalk, Fried Faassen, Herman Vromans, O de Vegt

Publikováno v: Part.Part.Syst.Charact., 22, 261-267. WILEY-V C H VERLAG GMBH
Particle & Particle Systems Characterization, 22(4), 261-267. WILEY-V C H VERLAG GMBH

The particle size distribution of fine chemicals in the solid state, like active pharmaceutical ingredients, is often a critical parameter. To achieve the desired particle size distribution, milling of such materials is usually the method of choice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bdf40fc3c088007967f2be3d0fd74b
https://research.rug.nl/en/publications/36c92696-7162-4cc1-a245-294ad28cd16e

Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties

Autor: K. Zuurman, Gerad Klaas Bolhuis, van der Kees Voort Maarschalk

Publikováno v: International Journal of Pharmaceutics, 179(1), 107-115. Elsevier Bedrijfsinformatie b.v.

The negative effect of magnesium stearate on tablet strength is widely known. This strength reduction is always considered to be the result of reduction of interparticle bonding. It is also known that interparticle bonding affects relaxation of table

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645362541951d329af63835978c12066
https://research.rug.nl/en/publications/869b9b22-a6b5-4b4a-9d33-27888901b0a2