Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of Frontotemporal Dementia.

Autor: Hok-A-Hin YS; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Vermunt L; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands., Peeters CFW; Mathematical & Statistical Methods group - Biometris, Wageningen University & Research, Wageningen, The Netherlands., van der Ende EL; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., de Boer SCM; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands.; School of Psychology and Brain & Mind Centre, The University of Sydney, Sydney, Australia., Meeter LH; Alzheimer center and department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., van Swieten JC; Alzheimer center and department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Hu WT; Department of Neurology, Center for Neurodegenerative Diseases Research, Emory University School of Medicine, Atlanta, USA., Lleó A; Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau (IIB SANT PAU) - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Alcolea D; Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau (IIB SANT PAU) - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Engelborghs S; Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Vrije Universiteit Brussel, Center for Neurosciences (C4N), Neuroprotection and Neuromodulation Research Group (NEUR), Brussels, Belgium.; Universitair Ziekenhuis Brussel, Department of Neurology, Brussels, Belgium., Sieben A; Lab of neuropathology, Neurobiobank, Institute Born-Bunge, Antwerp University, Edegem, Belgium., Chen-Plotkin A; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Irwin DJ; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., van der Flier WM; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands., Pijnenburg YAL; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Del Campo M; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, The Netherlands.; Barcelonaßeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San PabloCEU, CEU Universities, Madrid, Spain.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.

Distinctive cell-free DNA methylation characterizes presymptomatic genetic frontotemporal dementia.

Autor: Giannini LAA; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Boers RG; Department of Developmental Biology, Erasmus Medical Center, Rotterdam, The Netherlands., van der Ende EL; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Poos JM; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Jiskoot LC; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Boers JB; Department of Developmental Biology, Erasmus Medical Center, Rotterdam, The Netherlands., van IJcken WFJ; Erasmus Center for Biomics, Erasmus University Medical Center, Rotterdam, The Netherlands., Dopper EG; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Pijnenburg YAL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit, Amsterdam UMC location Vumc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Seelaar H; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Meeter LH; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., van Rooij JGJ; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Scheper W; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Faculty of Science, Vrije Universiteit, Amsterdam, The Netherlands.; Department of Human Genetics, Vrije Universiteit, Amsterdam UMC location Vumc, Amsterdam, The Netherlands., Gribnau J; Department of Developmental Biology, Erasmus Medical Center, Rotterdam, The Netherlands., van Swieten JC; Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 Mar; Vol. 11 (3), pp. 744-756. Date of Electronic Publication: 2024 Mar 13.

Clinical Value of Longitudinal Serum Neurofilament Light Chain in Prodromal Genetic Frontotemporal Dementia.

Autor: Giannini LAA; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Seelaar H; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., van der Ende EL; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Poos JM; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Jiskoot LC; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Dopper EGP; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Pijnenburg YAL; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Willemse EAJ; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Vermunt L; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Teunissen CE; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., van Swieten JC; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands., Meeter LH; From the Department of Neurology (L.A.A.G., H.S., J.M.P., L.C.J., E.G.P.D., J.C.S., L.H.M.), Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam; Amsterdam Neuroscience (E.L.E., Y.A.L.P., E.A.J.W., L.V., C.E.T.), Neurodegeneration; Neurochemistry Laboratory (E.L.E., E.A.J.W., L.V., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit; and Alzheimer Center Amsterdam (Y.A.L.P.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, The Netherlands. h.meeter@erasmusmc.nl.

Publikováno v: Neurology [Neurology] 2023 Sep 05; Vol. 101 (10), pp. e1069-e1082. Date of Electronic Publication: 2023 Jul 25.

Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia.

Autor: Poos JM; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Grandpierre LDM; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., van der Ende EL; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Panman JL; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Papma JM; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Seelaar H; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., van den Berg E; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., van 't Klooster R; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Bron E; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Steketee R; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Vernooij MW; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Pijnenburg YAL; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Rombouts SARB; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., van Swieten J; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Jiskoot LC; From the Department of Neurology and Alzheimer Center Erasmus MC (Jackie M. Poos, L.D.M.G., E.L.E., J.L.P., Janne M. Papma, H.S., Esther van den Berg, J.S., L.C.J.), Erasmus MC University Medical Center; Quantib B.V. (R.K.), Rotterdam; Departments of Radiology and Nuclear Medicine (Esther Bron, R.S., M.W.V.) and Epidemiology (M.W.V.), Erasmus MC University Medical Center Rotterdam; Department of Neurology (Y.A.L.P.), Alzheimer Center, Location VU University Medical Center Amsterdam Neuroscience, Amsterdam University Medical Center; Department of Radiology (S.A.R.B.R.), Leiden University Medical Center; Institute of Psychology (S.A.R.B.R.) and Leiden Institute for Brain and Cognition (S.A.R.B.R.), Leiden University, The Netherlands; and Dementia Research Centre (L.C.J.), Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom. l.c.jiskoot@erasmusmc.nl.

Publikováno v: Neurology [Neurology] 2022 Dec 12; Vol. 99 (24), pp. e2661-e2671. Date of Electronic Publication: 2022 Dec 12.

Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort.

Autor: Poos JM; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., MacDougall A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., van den Berg E; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Jiskoot LC; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Papma JM; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., van der Ende EL; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Seelaar H; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Russell LL; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Peakman G; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Convery R; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Pijnenburg YAL; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Moreno F; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Sanchez-Valle R; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Borroni B; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Laforce R Jr; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Doré MC; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Masellis M; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Tartaglia MC; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Graff C; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Galimberti D; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Rowe JB; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Finger E; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Synofzik M; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Vandenberghe R; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Mendonça A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Tiraboschi P; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Santana I; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Ducharme S; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Butler C; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Gerhard A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Levin J; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Danek A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Otto M; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Le Ber I; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Pasquier F; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., van Swieten J; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France., Rohrer JD; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of Neurology; Department of Medical Statistics (A.M.), London School of Hygiene and Tropical Medicine, UK; Department of Neurology (Y.A.L.P.), Alzheimer Center, Amsterdam University Medical Center, Amsterdam Neuroscience, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Centre for Neurodegenerative Disorders (B.B.), Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire (R.L., M.-C.D.), Département des Sciences Neurologiques, Université Laval, Québec; Sunnybrook Health Sciences Centre (M.M.), Sunnybrook Research Institute and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Ontario, Canada; Department of Geriatric Medicine (C.G.), Karolinska University Hospital-Huddinge, Stockholm, Sweden; Centro Dino Ferrari (D.G.), University of Milan; Fondazione IRCCS Ca' Granda (D.G.), Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy; Department of Clinical Neurosciences (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology (R.V.), Department of Neurosciences, KU Leuven, Belgium; Faculty of Medicine (A.M.), University of Lisbon, Portugal; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta (P.T.), Milan, Italy; Faculty of Medicine (I.S.), University of Coimbra, Portugal; Department of Psychiatry (S.D.), McGill University Health Centre, McGill University, Montreal, Québec, Canada; Department of Clinical Neurology (C.B.), University of Oxford; Divison of Neuroscience & Experimental Psychology (A.G.), Faculty of Medicine, Biology and Health, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), Essen University Hospital, Germany; Department of Neurology (J.L., A.D.), Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Munich Cluster for Systems Neurology (SyNergy) (J.L.); Department of Neurology (M.O.), University of Ulm, Germany; Sorbonne Université (I.L.B.), Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière; Centre de Référence des Démences Rares ou Précoces (I.L.B.), IM2A, Département de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière; Univ Lille (F.P.); Inserm 1172 (F.P.); and CHU (F.P.), CNR-MAJ, Labex Distalz, LiCEND, Lille, France. j.rohrer@ucl.ac.uk.

Publikováno v: Neurology [Neurology] 2022 Jul 19; Vol. 99 (3), pp. e281-e295. Date of Electronic Publication: 2022 Apr 28.