Výsledky vyhledávání - "van der Elst W"

Akademický článek

Evaluating time-to-event surrogates for time-to-event true endpoints: an information-theoretic approach based on causal inference.

Autor: Stijven F; KU Leuven, I-BioStat, Leuven, B-3000, Belgium. florian.stijven@kuleuven.be., Molenberghs G; KU Leuven, I-BioStat, Leuven, B-3000, Belgium.; Universiteit Hasselt, I-BioStat, Hasselt, B-3500, Belgium., Van Keilegom I; KU Leuven, ORSTAT, B-3000, Leuven, Belgium., Van der Elst W; The Janssen Pharmaceutical Companies of Johnson and Johnson, Beerse, Belgium., Alonso A; KU Leuven, I-BioStat, Leuven, B-3000, Belgium.

Publikováno v: Lifetime data analysis [Lifetime Data Anal] 2024 Oct 13. Date of Electronic Publication: 2024 Oct 13.

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Akademický článek

An information-theoretic approach for the assessment of a continuous outcome as a surrogate for a binary true endpoint based on causal inference: Application to vaccine evaluation.

Autor: Alonso Abad A; I-BioStat, KU Leuven, Leuven, Belgium., Ong F; I-BioStat, Universiteit Hasselt, Diepenbeek, Belgium., Stijven F; I-BioStat, KU Leuven, Leuven, Belgium., Van der Elst W; The Janssen Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium., Molenberghs G; I-BioStat, KU Leuven, Leuven, Belgium.; I-BioStat, Universiteit Hasselt, Diepenbeek, Belgium., Van Keilegom I; ORSTAT, KU Leuven, Leuven, Belgium., Verbeke G; I-BioStat, KU Leuven, Leuven, Belgium., Callegaro A; GSK Vaccines, Rixensart, Belgium.

Publikováno v: Statistics in medicine [Stat Med] 2024 Mar 15; Vol. 43 (6), pp. 1083-1102. Date of Electronic Publication: 2024 Jan 01.

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Akademický článek

Assessing the Operational Characteristics of the Individual Causal Association as a Metric of Surrogacy in the Binary Continuous Setting.

Autor: Ong F; I-BioStat, Department of Mathematics and Statistics, Universiteit Hasselt, Diepenbeek, Belgium., Molenberghs G; I-BioStat, Department of Mathematics and Statistics, Universiteit Hasselt, Diepenbeek, Belgium.; I-BioStat, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium., Callegaro A; Statistical Innovation and Data Science, GSK Vaccines, Rixensart, Belgium., Van der Elst W; Statistics and Decision Sciences, The Janssen Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium., Stijven F; I-BioStat, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium., Verbeke G; I-BioStat, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium., Van Keilegom I; ORSTAT, Faculty of Economics and Business Administration, KU Leuven, Leuven, Belgium., Alonso A; I-BioStat, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Publikováno v: Pharmaceutical statistics [Pharm Stat] 2024 Sep 29. Date of Electronic Publication: 2024 Sep 29.

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Akademický článek

Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies.

Autor: Rodrigues Martins D; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Therapeutic and Diagnostic Antibodies, Leuven, Belgium.; Janssen Pharmaceutica NV, Neuroscience Discovery, Beerse, Belgium., Sha F; Janssen Research and Development, Biologics Discovery, Spring House, PA, USA., Van der Elst W; Janssen Pharmaceutica NV, Translational Medicine and Early Development Statistics, Beerse, Belgium., Shih PY; Janssen Pharmaceutica NV, Neuroscience Discovery, Beerse, Belgium., Devoght J; Janssen Pharmaceutica NV, Neuroscience Discovery, Beerse, Belgium., Van Kolen K; Janssen Pharmaceutica NV, Neuroscience Discovery, Beerse, Belgium., Mercken M; Janssen Pharmaceutica NV, Neuroscience Discovery, Beerse, Belgium., Van Broeck B; Janssen Pharmaceutica NV, Neuroscience Discovery, Beerse, Belgium., Declerck P; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Therapeutic and Diagnostic Antibodies, Leuven, Belgium.; PharmAbs, The KU Leuven Antibody Center, Leuven, Belgium., Theunis C; Janssen Pharmaceutica NV, Neuroscience Discovery, Beerse, Belgium.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2023 Nov 14; Vol. 31, pp. 101158. Date of Electronic Publication: 2023 Nov 14 (Print Publication: 2023).

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Akademický článek

Identifying individual predictive factors for treatment efficacy.

Autor: Alonso A; I-BioStat, Catholic University of Leuven, Leuven, Belgium., Van der Elst W; Janssen Pharmaceutica, Companies of Johnson & Johnson, Belgium., Sanchez L; Center of Molecular Immunology, Havana, Cuba., Luaces P; Center of Molecular Immunology, Havana, Cuba., Molenberghs G; I-BioStat, Catholic University of Leuven, Leuven, Belgium.; I-BioStat, Hasselt University, Diepenbeek, Belgium.

Publikováno v: Biometrics [Biometrics] 2022 Mar; Vol. 78 (1), pp. 35-45. Date of Electronic Publication: 2020 Nov 22.

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Akademický článek

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Additional file 1 of Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

Autor: Tok, S., Maurin, H., Delay, C., Crauwels, D., Manyakov, N. V., Van Der Elst, W., Moechars, D., Drinkenburg, W. H. I. M.

Additional file 1. Supplementary document containing additional information on the Methods, Non-identifiable patient characteristics, Quality control data, as well as non-significant findings.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2643ceb0adecfe903618a610fd5dc99f

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Akademický článek

The individual-level surrogate threshold effect in a causal-inference setting with normally distributed endpoints.

Autor: Van der Elst W; The Janssen Pharmaceutical companies of Johnson & Johnson, Beerse, Belgium., Abad AA; I-BioStat, KU Leuven, Leuven, Belgium., Coppenolle H; The Janssen Pharmaceutical companies of Johnson & Johnson, Beerse, Belgium., Meyvisch P; Galapagos NV, Mechelen, Belgium., Molenberghs G; I-BioStat, KU Leuven, Leuven, Belgium.; UHasselt, Hasselt, Belgium.

Publikováno v: Pharmaceutical statistics [Pharm Stat] 2021 Nov; Vol. 20 (6), pp. 1216-1231. Date of Electronic Publication: 2021 May 21.

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