Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability.

Autor: Sin YY; School of Cardiovascular and Metabolic Health, University of Glasgow, UK., Cameron RT; School of Cardiovascular and Metabolic Health, University of Glasgow, UK., Schepers M; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, The Netherlands., MacLeod R; School of Cardiovascular and Metabolic Health, University of Glasgow, UK., Wright TA; School of Cardiovascular and Metabolic Health, University of Glasgow, UK., Paes D; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, The Netherlands., van den Hove D; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, The Netherlands., Willems E; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, The Netherlands., Vanmierlo T; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, The Netherlands., Prickaerts J; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, The Netherlands., Blair CM; School of Cardiovascular and Metabolic Health, University of Glasgow, UK., Baillie GS; School of Cardiovascular and Metabolic Health, University of Glasgow, UK.

Publikováno v: FEBS letters [FEBS Lett] 2024 Jul; Vol. 598 (13), pp. 1591-1604. Date of Electronic Publication: 2024 May 09.

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions.

Autor: Tiane A; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; University MS Center (UMSC) Hasselt, Pelt, Belgium., Schepers M; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; University MS Center (UMSC) Hasselt, Pelt, Belgium., Reijnders RA; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., van Veggel L; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; University MS Center (UMSC) Hasselt, Pelt, Belgium., Chenine S; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; University MS Center (UMSC) Hasselt, Pelt, Belgium., Rombaut B; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; University MS Center (UMSC) Hasselt, Pelt, Belgium., Dempster E; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK., Verfaillie C; Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Wasner K; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Grünewald A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Prickaerts J; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Pishva E; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK., Hellings N; University MS Center (UMSC) Hasselt, Pelt, Belgium.; Department of Immunology and Infection, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium., van den Hove D; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Würzburg, Germany., Vanmierlo T; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium. tim.vanmierlo@uhasselt.be.; Department Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. tim.vanmierlo@uhasselt.be.; University MS Center (UMSC) Hasselt, Pelt, Belgium. tim.vanmierlo@uhasselt.be.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2023 Aug; Vol. 146 (2), pp. 283-299. Date of Electronic Publication: 2023 Jun 07.

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology.

Autor: Paes D; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium., Schepers M; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium., Willems E; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium., Rombaut B; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium., Tiane A; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium., Solomina Y; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Tibbo A; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Blair C; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Kyurkchieva E; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Baillie GS; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Ricciarelli R; Section of General Pathology, Department of Experimental Medicine, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Brullo C; Section of Medicinal Chemistry, Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy., Fedele E; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Section of Pharmacology and Toxicology, Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy., Bruno O; Section of Medicinal Chemistry, Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy., van den Hove D; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany., Vanmierlo T; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. t.vanmierlo@maastrichtuniversity.nl.; Department of Neuroscience, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium. t.vanmierlo@maastrichtuniversity.nl., Prickaerts J; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. jos.prickaerts@maastrichtuniversity.nl.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 Jun 12; Vol. 80 (7), pp. 178. Date of Electronic Publication: 2023 Jun 12.

In vitro modeling of the neurobiological effects of glucocorticoids: A review.

Autor: Bassil K; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Krontira AC; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Munich, Germany., Leroy T; Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium., Escoto AIH; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Snijders C; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Pernia CD; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Pasterkamp RJ; Department of Translational Neuroscience, University Medical Center (UMC) Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands., de Nijs L; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., van den Hove D; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Kenis G; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Boks MP; Psychiatry, UMC Utrecht Brain Center, Utrecht, the Netherlands., Vadodaria K; Salk Institute for Biological Studies, La Jolla, San Diego, United States., Daskalakis NP; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Binder EB; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Munich, Germany., Rutten BPF; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.

Publikováno v: Neurobiology of stress [Neurobiol Stress] 2023 Feb 23; Vol. 23, pp. 100530. Date of Electronic Publication: 2023 Feb 23 (Print Publication: 2023).

Exogenous Oxytocin Administration Restores Memory in Female APP/PS1 Mice.

Autor: Koulousakis P; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium., Willems E; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium., Schepers M; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium., Rombaut B; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium., Prickaerts J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Vanmierlo T; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium., van den Hove D; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 96 (3), pp. 1207-1219.