Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis

Autor: Hougardy, BMT, Maduro, JH, van der Zee, AGJ, de Groot, DJA, van den Heuvel, FAJ, de Vries, EGE, de Jong, S

Publikováno v: International Journal of Cancer, 118(8), 1892-1900. Wiley

In cervical carcinogenesis, the p53 tumor suppressor pathway is disrupted by HPV (human papilloma virus) E6 oncogene expression. E6 targets p53 for rapid proteasome-mediated degradation. We therefore investigated whether proteasome inhibition by MG13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a0433cbddf539b9e7cc589da7ca0767d
https://research.rug.nl/en/publications/f7098733-5245-4567-8496-d44a304e008c

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Dietary methionine starvation impairs acute myeloid leukemia progression.

Autor: Cunningham A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Erdem A; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Alshamleh I; Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany., Geugien M; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pruis M; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pereira-Martins DA; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Internal Medicine, Medical School of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil., van den Heuvel FAJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Wierenga ATJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Ten Berge H; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Dennebos R; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van den Boom V; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hogeling SM; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Weinhäuser I; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Internal Medicine, Medical School of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil., Knops R; Department of Laboratory Medicine, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., de Blaauw P; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Heiner-Fokkema MR; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Woolthuis C; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Günther UL; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany., Rego EM; Department of Internal Medicine, Medical School of Ribeirao Preto, University of São Paulo, Ribeirão Preto, Brazil., Martens JHA; Department of Molecular Biology, RIMLS, Radboud University, Nijmegen, The Netherlands., Jansen JH; Department of Laboratory Medicine, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Schwalbe H; Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany., Huls G; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Schuringa JJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: Blood [Blood] 2022 Nov 10; Vol. 140 (19), pp. 2037-2052.