Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.

Autor: Wang G; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, the Netherlands., de Jong RN; Genmab, Yalelaan 60, 3584 CM Utrecht, the Netherlands., van den Bremer ET; Genmab, Yalelaan 60, 3584 CM Utrecht, the Netherlands., Beurskens FJ; Genmab, Yalelaan 60, 3584 CM Utrecht, the Netherlands., Labrijn AF; Genmab, Yalelaan 60, 3584 CM Utrecht, the Netherlands., Ugurlar D; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research and Department of Chemistry, Faculty of Science, Utrecht University, 3584 CH Utrecht, the Netherlands., Gros P; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research and Department of Chemistry, Faculty of Science, Utrecht University, 3584 CH Utrecht, the Netherlands., Schuurman J; Genmab, Yalelaan 60, 3584 CM Utrecht, the Netherlands., Parren PW; Genmab, Yalelaan 60, 3584 CM Utrecht, the Netherlands; Department of Immunohematology and Blood Transfusion, University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address: p.parren@genmab.com., Heck AJ; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, the Netherlands. Electronic address: a.j.r.heck@uu.nl.

Publikováno v: Molecular cell [Mol Cell] 2016 Jul 07; Vol. 63 (1), pp. 135-45. Date of Electronic Publication: 2016 Jun 16.

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation.

Autor: van den Bremer ET; a Genmab ; Utrecht , The Netherlands., Beurskens FJ, Voorhorst M, Engelberts PJ, de Jong RN, van der Boom BG, Cook EM, Lindorfer MA, Taylor RP, van Berkel PH, Parren PW

Publikováno v: MAbs [MAbs] 2015; Vol. 7 (4), pp. 672-80.

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches.

Autor: Gramer MJ; Genmab; Brooklyn Park, MN USA., van den Bremer ET; Genmab; Utrecht, the Netherlands., van Kampen MD; Genmab; Utrecht, the Netherlands., Kundu A; Genmab; Brooklyn Park, MN USA., Kopfmann P; Genmab; Brooklyn Park, MN USA., Etter E; Genmab; Brooklyn Park, MN USA., Stinehelfer D; Genmab; Brooklyn Park, MN USA., Long J; Genmab; Brooklyn Park, MN USA., Lannom T; Genmab; Brooklyn Park, MN USA., Noordergraaf EH; Genmab; Utrecht, the Netherlands., Gerritsen J; Genmab; Utrecht, the Netherlands., Labrijn AF; Genmab; Utrecht, the Netherlands., Schuurman J; Genmab; Utrecht, the Netherlands., van Berkel PH; Genmab; Utrecht, the Netherlands., Parren PW; Genmab; Utrecht, the Netherlands.

Publikováno v: MAbs [MAbs] 2013 Nov-Dec; Vol. 5 (6), pp. 962-73. Date of Electronic Publication: 2013 Aug 22.

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Autor: Labrijn AF; Genmab, 3584 CM, Utrecht, The Netherlands., Meesters JI, de Goeij BE, van den Bremer ET, Neijssen J, van Kampen MD, Strumane K, Verploegen S, Kundu A, Gramer MJ, van Berkel PH, van de Winkel JG, Schuurman J, Parren PW

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Mar 26; Vol. 110 (13), pp. 5145-50. Date of Electronic Publication: 2013 Mar 11.

Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength.

Autor: Labrijn AF; Genmab, 3584 CM Utrecht, The Netherlands., Rispens T, Meesters J, Rose RJ, den Bleker TH, Loverix S, van den Bremer ET, Neijssen J, Vink T, Lasters I, Aalberse RC, Heck AJ, van de Winkel JG, Schuurman J, Parren PW

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2011 Sep 15; Vol. 187 (6), pp. 3238-46. Date of Electronic Publication: 2011 Aug 12.