Neuropsychiatric copy number variants exert shared effects on human brain structure

Autor: Sandra Martin-Brevet, Kuldeep Kumar, Clara Moreau, M. Mallar Chakravarty, Florence Deguire, Elise Douard, Guillaume Huguet, Sarah Lippé, Carrie E. Bearden, Sébastien Jacquemont, Fanny Thébault-Dagher, Claudia Modenato, Sonia Richetin, Charlebois A, Danilo Bzdok, Côté, Bogdan Draganski, Aurélie Pain, Lester Melie-Garcia, van den Bree Mb, Ana I. Silva, Jean-Louis Martineau, Nadine Younis, Petra Tamer, Anne M. Maillard, Charles-Olivier Martin, Jeremy Hall, Michael John Owen, Leila Kushan, David E. J. Linden, Catherine Schramm, Borja Rodriguez-Herreros

BackgroundCopy Number Variants (CNVs) associated with autism and schizophrenia have large effects on brain anatomy. Yet, neuroimaging studies have been conducted one mutation at a time. We hypothesize that neuropsychiatric CNVs may exert general effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086464c3d6d0495dacfa4a98dbcc0a6a
https://doi.org/10.1101/2020.04.15.20056531

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16p11.2 Locus modulates response to satiety before the onset of obesity.

Autor: Maillard AM; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Hippolyte L; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Rodriguez-Herreros B; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.; LREN-Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Chawner SJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Dremmel D; Department of Psychology, Clinical Psychology and Psychotherapy, University of Fribourg, Fribourg, Switzerland., Agüera Z; CIBER Fisiopatologia Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Barcelona, Spain.; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain., Fagundo AB; CIBER Fisiopatologia Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Barcelona, Spain.; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain., Pain A; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Martin-Brevet S; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.; LREN-Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Hilbert A; Integrated Research and Treatment Center Adiposity Diseases, Department of Medical Psychology and Medical SocCiology, University of Leipzig Medical Center, Leipzig, Germany., Kurz S; Department of Psychology, Clinical Psychology and Psychotherapy, University of Fribourg, Fribourg, Switzerland., Etienne R; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Draganski B; LREN-Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.; Department of Neurology, Max-Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany., Jimenez-Murcia S; CIBER Fisiopatologia Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Barcelona, Spain.; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain.; Clinical Sciences Department, School of Medicine, Barcelona, Spain., Männik K; Estonian Genome Center, Tartu University Hospital, Tartu, Estonia.; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Metspalu A; Estonian Genome Center, Tartu University Hospital, Tartu, Estonia., Reigo A; Estonian Genome Center, Tartu University Hospital, Tartu, Estonia., Isidor B; Service de Génétique Médicale, CHU-Nantes, Nantes, France., Le Caignec C; Service de Génétique Médicale, CHU-Nantes, Nantes, France.; INSERM UMR957, Faculté de Médecine, Nantes, France., David A; Service de Génétique Médicale, CHU-Nantes, Nantes, France., Mignot C; AP-HP, Hôpital Pitié-Salpêtrière, Département de Génétique et de Cytogénétique, Unité Fonctionnelle de Génétique Clinique, Paris, France.; Centre de Référence Déficiences Intellectuelles de Causes Rares, Paris, France.; Groupe de Recherche Clinique Déficience Intellectuelle et Autisme, UPMC, Paris, France., Keren B; Groupe Hospitalier Pitié Salpêtrière, AP-HP, Department of Genetics and Cytogenetics, Paris, France., van den Bree MB; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Munsch S; Department of Psychology, Clinical Psychology and Psychotherapy, University of Fribourg, Fribourg, Switzerland., Fernandez-Aranda F; CIBER Fisiopatologia Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Barcelona, Spain.; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain.; Clinical Sciences Department, School of Medicine, Barcelona, Spain., Beckmann JS; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Reymond A; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Jacquemont S; Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

Publikováno v: International journal of obesity (2005) [Int J Obes (Lond)] 2016 May; Vol. 40 (5), pp. 870-6. Date of Electronic Publication: 2015 Dec 01.

Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities.

Autor: D'Angelo D; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York., Lebon S; Pediatric Neurology Unit, Department of Pediatrics, Lausanne University Hospital, Lausanne, Switzerland., Chen Q; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York., Martin-Brevet S; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Snyder LG; Clinical Research Associates, New York, New York., Hippolyte L; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Hanson E; Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Maillard AM; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Faucett WA; Genomic Medicine Institute, Geisinger Clinic, Danville, Pennsylvania., Macé A; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland7Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland., Pain A; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Bernier R; Department of Psychiatry and Behavioral Science, University of Washington, Seattle., Chawner SJ; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales., David A; Service de Génétique Médicale, Faculté de Médecine, Centre Hospitalier Universitaire (CHU) Nantes, Institut National de la Santé et de la Recherche Medicale (INSERM) Unités Mixtes de Recherche 957, Nantes, France., Andrieux J; Institut de Génétique Médicale, Hospital Jeanne de Flandre, Centre Hospitalier Régional Universitaire (CHRU) de Lille, Lille, France., Aylward E; Center for Integrative Brain Research, Children's Research Institute, Seattle, Washington., Baujat G; Département de Génétique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France 14INSERM U1163, Hôpital Necker-Enfants Malades, Paris, France15Institut Imagine, Université Paris Descartes-Sorbonne Paris Cité, Paris., Caldeira I; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Conus P; Department of Psychiatry, Cery Hospital, CHU Vaudois and University of Lausanne, Lausanne, Switzerland., Ferrari C; Department of Psychiatry, Cery Hospital, CHU Vaudois and University of Lausanne, Lausanne, Switzerland., Forzano F; Division of Medical Genetics, Galliera Hospital, Genova, Italy., Gérard M; Departement de Génétique, AP-HP, Hôpital Robert Debré, Université Paris VII-Paris Diderot, Paris, France., Goin-Kochel RP; Section of Psychology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Grant E; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Hunter JV; Department of Radiology, Baylor College of Medicine, Houston, Texas., Isidor B; Service de Génétique Médicale, Faculté de Médecine, Centre Hospitalier Universitaire (CHU) Nantes, Institut National de la Santé et de la Recherche Medicale (INSERM) Unités Mixtes de Recherche 957, Nantes, France., Jacquette A; Département de Génétique et de Cytogénétique, Unité fonctionnelle de Génétique Clinique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France23Centre de Référence Déficiences Intellectuelles de Causes Rares, Paris, France24Groupe de Recherche Clinique, Déficie., Jønch AE; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Keren B; Department of Genetics and Cytogenetics, Groupe Hospitalier Pitié Salpêtrière, AP-HP, Paris, France., Lacombe D; Service de Génétique Médicale, Faculté de Médecine, Centre Hospitalier Universitaire (CHU) Nantes, Institut National de la Santé et de la Recherche Medicale (INSERM) Unités Mixtes de Recherche 957, Nantes, France26Service de Génétique Médicale, CHU de Bor., Le Caignec C; Service de Génétique Médicale, Faculté de Médecine, Centre Hospitalier Universitaire (CHU) Nantes, Institut National de la Santé et de la Recherche Medicale (INSERM) Unités Mixtes de Recherche 957, Nantes, France., Martin CL; Autism and Developmental Medicine Institute, Geisinger Health System, Danville, Pennsylvania., Männik K; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland29Estonian Genome Center, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia30Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Mignot C; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Mukherjee P; Department of Radiology and Biomedical Imaging, University of California, San Francisco., Owen MJ; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales., Passeggeri M; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Rooryck-Thambo C; Service de Génétique Médicale, CHU de Bordeaux, Bordeaux, France32Laboratoire Maladies Rares: Génétique et Métabolisme, Université de Bordeaux, Bordeaux, France., Rosenfeld JA; Signature Genomic Laboratories, LLC, PerkinElmer, Inc, Spokane., Spence SJ; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Steinman KJ; Department of Neurology, Seattle Children's Research Institute and University of Washington, Seattle., Tjernagel J; Clinical Research Associates, New York, New York., Van Haelst M; Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands., Shen Y; Genetic Diagnostic Laboratory, Department of Laboratory Medicine, Children's Hospital, Boston, Massachusetts., Draganski B; Laboratoire de Recherche en Neuroimagerie, Department for Clinical Neurosciences, Centre Hospitalo-Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland., Sherr EH; Department of Neurology, University of California, San Francisco., Ledbetter DH; Autism and Developmental Medicine Institute, Geisinger Health System, Danville, Pennsylvania., van den Bree MB; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales., Beckmann JS; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland7Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland., Spiro JE; Simons Foundation, New York, New York., Reymond A; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Jacquemont S; Department of Medical Genetics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland41CHU Sainte-Justine Research Center, Montreal, Canada42Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada., Chung WK; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York44Department of Medicine, Columbia University, New York, New York.

Publikováno v: JAMA psychiatry [JAMA Psychiatry] 2016 Jan; Vol. 73 (1), pp. 20-30.

The Developmental Relationship Between Depressive Symptoms in Adolescence and Harmful Drinking in Emerging Adulthood: The Role of Peers and Parents.

Autor: Pesola F; Wolfson Institute for Preventive Medicine, Queen Mary University of London, London, EC1M 6BQ, UK, f.pesola@qmul.ac.uk., Shelton KH, Heron J, Munafò M, Hickman M, van den Bree MB

Publikováno v: Journal of youth and adolescence [J Youth Adolesc] 2015 Sep; Vol. 44 (9), pp. 1752-66. Date of Electronic Publication: 2015 May 15.