Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association.

Autor: van den Beukel MD; Immunology, Leiden University Medical Center, Leiden, The Netherlands., van Wesemael TJ; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Hoogslag ATW; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Borggreven NV; Immunology, Leiden University Medical Center, Leiden, The Netherlands., Huizinga TW; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., van der Helm-van Mil AH; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands., Toes RE; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., van der Woude D; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Trouw LA; Immunology, Leiden University Medical Center, Leiden, The Netherlands l.a.trouw@lumc.nl.

Publikováno v: RMD open [RMD Open] 2023 Dec 01; Vol. 9 (4). Date of Electronic Publication: 2023 Dec 01.

Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment.

Autor: van den Beukel MD; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands., Stoelinga AEC; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands., van der Meer AJ; Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands., van der Meulen S; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands., Zhang L; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands., Tushuizen ME; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands., van Hoek B; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands., Trouw LA; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands.

Publikováno v: Frontiers in medicine [Front Med (Lausanne)] 2023 Jul 25; Vol. 10, pp. 1195747. Date of Electronic Publication: 2023 Jul 25 (Print Publication: 2023).

Naturally produced type I IFNs enhance human myeloid dendritic cell maturation and IL-12p70 production and mediate elevated effector functions in innate and adaptive immune cells.

Autor: Sköld AE; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.; Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden., Mathan TSM; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands., van Beek JJP; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands., Flórez-Grau G; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands., van den Beukel MD; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands., Sittig SP; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands., Wimmers F; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands., Bakdash G; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.; Allergic Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, United Kingdom., Schreibelt G; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands., de Vries IJM; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands. Jolanda.deVries@radboudumc.nl.; Department of Medical Oncology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands. Jolanda.deVries@radboudumc.nl.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2018 Sep; Vol. 67 (9), pp. 1425-1436. Date of Electronic Publication: 2018 Jul 13.