Výsledky vyhledávání - "van Weverwijk A"

Akademický článek

Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

Autor: Ute Jungwirth, Antoinette van Weverwijk, Rachel J. Evans, Liam Jenkins, David Vicente, John Alexander, Qiong Gao, Syed Haider, Marjan Iravani, Clare M. Isacke

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulti

Externí odkaz: https://doaj.org/article/d33b1b683b5f48278db9816c890eda30

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Akademický článek

Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

Autor: Antoinette van Weverwijk, Nikolaos Koundouros, Marjan Iravani, Matthew Ashenden, Qiong Gao, George Poulogiannis, Ute Jungwirth, Clare M. Isacke

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Cancer cells must develop distinct metabolic adaptations to survive in challenging metastatic environments. Here, the authors find, via an in vivo RNAi screen, that the aldo-keto reductase AKR1B10 limits the toxic side effects of oxidative stress to

Externí odkaz: https://doaj.org/article/58bc19073e294af1870da5b4ec93e431

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Akademický článek

Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain

Autor: Magdalena Kijewska, Carmen Viski, Frances Turrell, Amanda Fitzpatrick, Antoinette van Weverwijk, Qiong Gao, Marjan Iravani, Clare M. Isacke

Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)

Abstract Background Dissemination of breast cancers to the brain is associated with poor patient outcome and limited therapeutic options. In this study we sought to identify novel regulators of brain metastasis by profiling mouse mammary carcinoma ce

Externí odkaz: https://doaj.org/article/d5f67fc6448a4998bc92a5ac2546bcdf

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