Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma.

Autor: Borgers JSW; Medical Oncology, Netherlands Cancer Institute, Amsterdam, Noord-Holland, Netherlands., van Wesemael TJ; Rheumatology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands., Gelderman KA; Sanquin Diagnostic Services, Amsterdam, Noord-Holland, Netherlands., Rispens T; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam, Noord-Holland, UK., Verdegaal EME; Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands., Moes DJAR; Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands., Korse CM; Laboratory Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands., Kapiteijn E; Department of Medical Oncology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands., Welters MJP; Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, Netherlands., van der Burg SH; Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, Netherlands., van Houdt WJ; Surgical Oncology, Netherlands Cancer Institute, Amsterdam, Noord-Holland, Netherlands., van Thienen JV; Medical Oncology, Netherlands Cancer Institute, Amsterdam, Noord-Holland, Netherlands., Haanen JBAG; Medical Oncology, Netherlands Cancer Institute, Amsterdam, Noord-Holland, Netherlands j.haanen@nki.nl.; Department of Medical Oncology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands., van der Woude D; Rheumatology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Jun 30; Vol. 12 (6). Date of Electronic Publication: 2024 Jun 30.

Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association.

Autor: van den Beukel MD; Immunology, Leiden University Medical Center, Leiden, The Netherlands., van Wesemael TJ; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Hoogslag ATW; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Borggreven NV; Immunology, Leiden University Medical Center, Leiden, The Netherlands., Huizinga TW; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., van der Helm-van Mil AH; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands., Toes RE; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., van der Woude D; Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Trouw LA; Immunology, Leiden University Medical Center, Leiden, The Netherlands l.a.trouw@lumc.nl.

Publikováno v: RMD open [RMD Open] 2023 Dec 01; Vol. 9 (4). Date of Electronic Publication: 2023 Dec 01.

From phenotype to pathophysiology-placing rheumatic diseases in an immunological perspective.

Autor: van Wesemael TJ; Leiden University Medical Center, Stafcentrum Reumatologie, 2300 RC Leiden, Netherlands. Electronic address: T.J.van_wesemael@lumc.nl., Huizinga TWJ; Leiden University Medical Center, Stafcentrum Reumatologie, 2300 RC Leiden, Netherlands., Toes REM; Leiden University Medical Center, Stafcentrum Reumatologie, 2300 RC Leiden, Netherlands., van der Woude D; Leiden University Medical Center, Stafcentrum Reumatologie, 2300 RC Leiden, Netherlands.

Publikováno v: The Lancet. Rheumatology [Lancet Rheumatol] 2022 Mar; Vol. 4 (3), pp. e166-e167. Date of Electronic Publication: 2022 Jan 05.

Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se: a multicenter cohort study.

Autor: van Wesemael TJ; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands. tinekevanwesemael@gmail.com., Ajeganova S; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands.; Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden., Humphreys J; Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, UK., Terao C; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for the Promotion of Interdisciplinary Education and Research, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Muhammad A; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands., Symmons DP; Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, UK.; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK., MacGregor AJ; Norwich Medical School, University of East Anglia, Norwich, UK., Hafström I; Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden., Trouw LA; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands., van der Helm-van Mil AH; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands., Huizinga TW; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands., Mimori T; Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Toes RE; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Svensson B; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden., Verstappen SM; Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, UK., van der Woude D; Department of Rheumatology C1-R, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands.

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2016 Dec 01; Vol. 18 (1), pp. 285. Date of Electronic Publication: 2016 Dec 01.