A spitting image: molecular diagnostics applied to saliva enhance detection of and pneumococcal serotype carriage

Autor: Miellet, Willem R, van Veldhuizen, Janieke, Litt, David, Mariman, Rob, Wijmenga-Monsuur, Alienke J, Nieuwenhuijsen, Tessa, Christopher, Jennifer, Thombre, Rebecca, Eletu, Seyi, Bosch, Thijs, Rots, Nynke Y, van Houten, Marianne Alice, Miller, Elizabeth, Fry, Norman K, Sanders, Elisabeth A M, Trzciński, Krzysztof

Quantitative PCR (qPCR)-based methods were applied to detect pneumococcus and pneumococcal serotypes in 971 saliva samples collected from 653 toddlers and 318 adults. Results were compared with culture-based and qPCR-based detection in nasopharyngeal

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http://hdl.handle.net/10029/626684

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Comparative genomics reveals a lack of evidence for pigeons as a main source of stx-carrying Escherichia coli causing disease in humans and the common existence of hybrid Shiga toxin-producing and enteropathogenic E. coli pathotypes

Autor: van Hoek, Angela H A M, van Veldhuizen, Janieke N J, Friesema, Ingrid, Coipan, Claudia, Rossen, John W A, Bergval, Indra L, Franz, Eelco

Wild birds, in particular pigeons are considered a natural reservoir for stx Serotypes and sequence types of stx Comparative genomics revealed that isolates from mild human disease are dominated by serotypes not encountered in the pigeon reservoir. I

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http://hdl.handle.net/10029/623056

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Impact of age on pneumococcal colonization of the nasopharynx and oral cavity: an ecological perspective.

Autor: Miellet WR; Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht (UMCU), Wilhelmina Children's Hospital, Utrecht, 3584 CX, The Netherlands.; Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands., Mariman R; Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands., van Veldhuizen J; Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands., Badoux P; Regional Laboratory of Public Health (Streeklab) Haarlem, Haarlem, 2035 RC, The Netherlands., Wijmenga-Monsuur AJ; Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands., Litt D; Respiratory and Vaccine Preventable Bacterial Reference Unit (RVPBRU) and Immunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, NW9 5EQ, United Kingdom., Bosch T; Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands., Miller E; School of Hygiene and Tropical Medicine, Department of Infectious Disease Epidemiology, London, WC1E 7HT, United Kingdom., Fry NK; Respiratory and Vaccine Preventable Bacterial Reference Unit (RVPBRU) and Immunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, NW9 5EQ, United Kingdom., van Houten MA; Department of Pediatrics, Spaarne Gasthuis, Haarlem, 2035 RC, The Netherlands., Rots NY; Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands., Sanders EAM; Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht (UMCU), Wilhelmina Children's Hospital, Utrecht, 3584 CX, The Netherlands.; Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, 3721 MA, The Netherlands., Trzciński K; Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht (UMCU), Wilhelmina Children's Hospital, Utrecht, 3584 CX, The Netherlands.

Publikováno v: ISME communications [ISME Commun] 2024 Jan 12; Vol. 4 (1), pp. ycae002. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2024).