Zobrazeno 1 - 10
of 308
pro vyhledávání: '"van Steeg, P."'
Akademický článek
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Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Externí odkaz:
https://doaj.org/article/44a09dce31cb497bae23d58181211464
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging. Interventions that either prevent DNA damage or enhance DNA repair are thus likely to extend health- a
Externí odkaz:
https://doaj.org/article/8c65fef761fc4154867530db3ca88371
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Akademický článek
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Autor:
Linda W M van Kerkhof, Kirsten C G Van Dycke, Eugene H J M Jansen, Piet K Beekhof, Conny T M van Oostrom, Tatjana Ruskovska, Nevenka Velickova, Nikola Kamcev, Jeroen L A Pennings, Harry van Steeg, Wendy Rodenburg
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135652 (2015)
Many molecular epidemiology studies focusing on high prevalent diseases, such as metabolic disorders and cancer, investigate metabolic and hormonal markers. In general, sampling for these markers can occur at any time-point during the day or after an
Externí odkaz:
https://doaj.org/article/a0cc15bc6080426aa52cd8a135fa0b99
Autor:
Kirsten C G Van Dycke, Jeroen L A Pennings, Conny T M van Oostrom, Linda W M van Kerkhof, Harry van Steeg, Gijsbertus T J van der Horst, Wendy Rodenburg
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127075 (2015)
Frequent shift work causes disruption of the circadian rhythm and might on the long-term result in increased health risk. Current biomarkers evaluating the presence of circadian rhythm disturbance (CRD), including melatonin, cortisol and body tempera
Externí odkaz:
https://doaj.org/article/fc0be2c1e607404bacf772708796c386
Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.
Autor:
Franny Jongbloed, Ron W F de Bruin, Jeroen L A Pennings, César Payán-Gómez, Sandra van den Engel, Conny T van Oostrom, Alain de Bruin, Jan H J Hoeijmakers, Harry van Steeg, Jan N M IJzermans, Martijn E T Dollé
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100853 (2014)
Ischemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that preoperative fasting in young-lean male mice protects against IRI. Since patients are generally of
Externí odkaz:
https://doaj.org/article/abca3416cb024ce49d1289932593833f
Autor:
Erwin Reiling, Martijn E T Dollé, Sameh A Youssef, Moonsook Lee, Bhawani Nagarajah, Marianne Roodbergen, Piet de With, Alain de Bruin, Jan H Hoeijmakers, Jan Vijg, Harry van Steeg, Paul Hasty
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93568 (2014)
Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80-/- mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs-/- mice. Ho
Externí odkaz:
https://doaj.org/article/4ea8161befee4fbc84c4cdd146c34eb2
Autor:
Yong Jun Choi, Han Li, Mi Young Son, Xiao-Hong Wang, Jamie L Fornsaglio, Robert W Sobol, Moonsook Lee, Jan Vijg, Sandra Imholz, Martijn E T Dollé, Harry van Steeg, Erwin Reiling, Paul Hasty
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86358 (2014)
Ku70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS) to repair DNA double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway. As expected mutating the
Externí odkaz:
https://doaj.org/article/4327812d0d2d46d893dd1dfbc4ba9f0c