Skewed X-inactivation is common in the general female population

Autor: Shvetsova, E, Sofronova, A, Monajemi, R, Gagalova, K, Draisma, HHM, White, SJ, Santen, GWE, Lopes, SMCDS, Heijmans, BT, Van Meurs, J, Jansen, R, Franke, L, Kielbasa, SM, Den Dunnen, JT, 't Hoen, PAC, Boomsma, DI, Pool, R, Van Dongen, J, Hottenga, JJ, Van Greevenbroek, MMJ, Da Stehouwer, C, Van der Kallen, CJH, Schalkwijk, CG, Wijmenga, C, Zhernakova, S, Tigchelaar, EF, Slagboom, PE, Beekman, M, Deelen, J, Van Heemst, D, Veldink, JH, Van den Berg, LH, Van Duijn, CM, Hofman, BA, Uitterlinden, AG, Jhamai, PM, Verbiest, M, Suchiman, HED, Verkerk, M, Van der Breggen, R, Van Rooij, J, Lakenberg, N, Mei, H, Bot, J, Zhernakova, DV, 't Hof, PV, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Luijk, R, Bonder, MJ, Van Iterson, M, Van Dijk, F, Van Galen, M, Arindrarto, W, Swertz, MA, Van Zwet, EW, Isaacs, A, Francioli, LC, Menelaou, A, Pulit, SL, Palamara, PF, Elbers, CC, Neerincx, PB, Ye, K, Guryev, V, Kloosterman, WP, Abdellaoui, A, Van Leeuwen, EM, Van Oven, M, Li, M, Laros, JF, Karssen, LC, Kanterakis, A, Amin, N, Lameijer, EW, Kattenberg, M, Dijkstra, M, Byelas, H, Van Setten, J, Van Schaik, BD, Nijman, IJ, Renkens, I, Marschall, T, Schonhuth, A, Hehir-Kwa, JY, Handsaker, RE, Polak, P, Sohail, M, Vuzman, D, Hormozdiari, F, Van Enckevort, D, Koval, V, Moed, MH, Van der Velde, KJ, Rivadeneira, F, Estrada, K, Medina-Gomez, C, McCarroll, SA, De Craen, AJ, Suchiman, HE, Oostra, B, Willemsen, G, Platteel, M, Pitts, SJ, Potluri, S, Sundar, P, Cox, DR, Sunyaev, SR, Stoneking, M, De Knijff, P, Kayser, M, Li, Q, Li, Y, Du, Y, Chen, R, Cao, H, Li, N, Cao, S, Wang, J, Bovenberg, JA, Pe'er, I, Van Ommen, GJ, De Bakker, PI

Publikováno v: European Journal of Human Genetics
European Journal of Human Genetics, 27(3), 455-465. Nature Publishing Group
European journal of human genetics, 27(3), 455-465. Nature Publishing Group
European Journal of Human Genetics, 27(3), 455-465
European Journal of Human Genetics, 27, 455-465
European Journal of Human Genetics, 27(3), 455. Nature Publishing Group
European Journal of Human Genetics, 27, 3, pp. 455-465
Shvetsova, E, 't Hoen, P A C, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Willemsen, G & BIOS Consortium 2019, ' Skewed X-inactivation is common in the general female population ', European Journal of Human Genetics, vol. 27, no. 3, pp. 455-465 . https://doi.org/10.1038/s41431-018-0291-3
Shvetsova, E, Sofronova, A, Monajemi, R, Gagalova, K, Draisma, H H M, White, S J, Santen, G W E, Chuva de Sousa Lopes, S M, Heijmans, B T, van Meurs, J, Jansen, R, Franke, L, Kiełbasa, S M, den Dunnen, J T, ‘t Hoen, P A C & BIOS Consortium 2019, ' Skewed X-inactivation is common in the general female population ', European Journal of Human Genetics, vol. 27, no. 3, pp. 455-465 . https://doi.org/10.1038/s41431-018-0291-3

X-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Skewed X-inactivation is often explained by negative selection of one of the alleles. We dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d16e7db74a66781c04e9903128640a4
https://doi.org/10.1038/s41431-018-0291-3

T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma.

Autor: Vroman H; Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., Balzaretti G; Clinical Immunology & Rheumatology, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands.; Experimental Immunology, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands., Belderbos RA; Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., Klarenbeek PL; Clinical Immunology & Rheumatology, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands.; Experimental Immunology, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands., van Nimwegen M; Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Bezemer K; Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., Cornelissen R; Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Niewold ITG; Laboratory of Genome Analysis, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands., van Schaik BD; Clinical Epidemiology, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands., van Kampen AH; Clinical Epidemiology, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands., Aerts JGJV; Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., de Vries N; Clinical Immunology & Rheumatology, Amsterdam UMC - Locatie AMC, Amsterdam, The Netherlands., Hendriks RW; Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands r.hendriks@erasmusmc.nl.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Mar; Vol. 8 (1).

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

Autor: Klarenbeek PL; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America; Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Laboratory for Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Doorenspleet ME; Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Laboratory for Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Esveldt RE; Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., van Schaik BD; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, University of Amsterdam, Amsterdam, The Netherlands., Lardy N; Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, The Netherlands., van Kampen AH; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, University of Amsterdam, Amsterdam, The Netherlands., Tak PP; Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Plenge RM; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America., Baas F; Laboratory for Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., de Bakker PI; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America; Department of Epidemiology, University Medical Center, Utrecht, The Netherlands; Department of Medical Genetics, University Medical Center, Utrecht, The Netherlands., de Vries N; Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Publikováno v: PloS one [PLoS One] 2015 Oct 30; Vol. 10 (10), pp. e0140815. Date of Electronic Publication: 2015 Oct 30 (Print Publication: 2015).

Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function.

Autor: Remmerswaal EB; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands e.b.remmerswaal@amc.uva.nl., Klarenbeek PL; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, the Netherlands Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands., Alves NL; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands., Doorenspleet ME; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, the Netherlands Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands., van Schaik BD; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands., Esveldt RE; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, the Netherlands Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands., Idu MM; Department of Surgery, Academic Medical Center, Amsterdam, the Netherlands., van Leeuwen EM; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands., van der Bom-Baylon N; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands., van Kampen AH; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands., Koch SD; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands., Pircher H; Institute of Immunology, University of Freiburg, Freiburg, Germany., Bemelman FJ; Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands., Ten Brinke A; Sanquin Research at CLB, Amsterdam, the Netherlands., Baas F; Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands., Ten Berge IJ; Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands., van Lier RA; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands Sanquin Research at CLB, Amsterdam, the Netherlands., de Vries N; Department of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, the Netherlands.

Publikováno v: Journal of virology [J Virol] 2015 Jan; Vol. 89 (1), pp. 568-80. Date of Electronic Publication: 2014 Oct 22.

Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity.

Autor: Doorenspleet ME; Department of Clinical Immunology & Rheumatology, Academic Medical Center of the University of Amsterdam, , Amsterdam, The Netherlands., Klarenbeek PL, de Hair MJ, van Schaik BD, Esveldt RE, van Kampen AH, Gerlag DM, Musters A, Baas F, Tak PP, de Vries N

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2014 Apr; Vol. 73 (4), pp. 756-62. Date of Electronic Publication: 2013 Apr 20.