Modeling cartilage pathology in mucopolysaccharidosis VI using iPSCs reveals early dysregulation of chondrogenic and metabolic gene expression

Autor: Broeders, M., van Rooij, Jgj, Oussoren, E., van Gestel, Tjm, Smith, Ca, Kimber, Sj, Verdijk, Rm, Wagenmakers, Maem, van den Hout, Jmp, van der Ploeg, At, Narcisi, R., Pijnappel, Wwmp

Publikováno v: Frontiers in Bioengineering and Biotechnology, 10:949063. Frontiers Media S.A.

Mucopolysaccharidosis type VI (MPS VI) is a metabolic disorder caused by disease-associated variants in the Arylsulfatase B (ARSB) gene, resulting in ARSB enzyme deficiency, lysosomal glycosaminoglycan accumulation, and cartilage and bone pathology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c126ab3ae5762f8e0e5df626082e250
https://pubmed.ncbi.nlm.nih.gov/36561048

Effects and interaction of single nucleotide polymorphisms at the pharmacokinetic/pharmacodynamic site: insights from the Rotterdam study into metformin clinical response and dose titration.

Autor: Mohammadi Jouabadi S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. s.mohammadi@erasmusmc.nl.; Division of Vascular Disease and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. s.mohammadi@erasmusmc.nl., Peymani P; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; College of pharmacy, University of Manitoba, Winnipeg, MB, Canada., Nekouei Shahraki M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., van Rooij JGJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Broer L; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Roks AJM; Division of Vascular Disease and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Stricker BH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Ahmadizar F; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Data Science and Biostatistics, Julius Global Health, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2024 Oct 07; Vol. 24 (6), pp. 31. Date of Electronic Publication: 2024 Oct 07.

Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts.

Autor: Kuiper LM; Center for Prevention, Lifestyle and Health, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Smit AP; Center for Prevention, Lifestyle and Health, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bizzarri D; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Leiden Computational Biology Center, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Delft Bioinformatics Lab, TU Delft, Delft, the Netherlands., van den Akker EB; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Leiden Computational Biology Center, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Delft Bioinformatics Lab, TU Delft, Delft, the Netherlands., Reinders MJT; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Leiden Computational Biology Center, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Delft Bioinformatics Lab, TU Delft, Delft, the Netherlands., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., van Rooij JGJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Voortman T; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, California, USA., Rivadeneira F; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Dollé MET; Center for Health Protection, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands., Herber GCM; Center for Prevention, Lifestyle and Health, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands., Rietman ML; Center for Prevention, Lifestyle and Health, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands., Picavet HSJ; Center for Prevention, Lifestyle and Health, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands., van Meurs JBJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Orthopaedics & Sports, Erasmus Medical Center, Rotterdam, the Netherlands., Verschuren WMM; Center for Prevention, Lifestyle and Health, National Institute for Public Health and Environment (RIVM), Bilthoven, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: monique.verschuren@rivm.nl.

Publikováno v: Mechanisms of ageing and development [Mech Ageing Dev] 2024 Aug; Vol. 220, pp. 111958. Date of Electronic Publication: 2024 Jun 29.

Lifestyle Intervention Randomized Controlled Trial for Age-Related Macular Degeneration (AMD-Life): Study Design.

Autor: de Koning-Backus APM; Department of Ophthalmology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Kiefte-de Jong JC; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Public Health and Primary Care, Health Campus The Hague, Leiden University Medical Center, 2333 ZA The Hague, The Netherlands., van Rooij JGJ; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Amd-Life Team; AMD-Life Team, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Uitterlinden AG; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Voortman TG; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Division of Human Nutrition and Health, Wageningen University & Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands., Meester-Smoor MA; Department of Ophthalmology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Klaver CCW; Department of Ophthalmology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Ophthalmology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.; Institute of Molecular and Clinical Ophthalmology, University of Basel, CH-4031 Basel, Switzerland.

Publikováno v: Nutrients [Nutrients] 2023 Jan 24; Vol. 15 (3). Date of Electronic Publication: 2023 Jan 24.

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.

Autor: Holstege H; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands. h.holstege@amsterdamumc.nl.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands. h.holstege@amsterdamumc.nl.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands. h.holstege@amsterdamumc.nl.; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands. h.holstege@amsterdamumc.nl., Hulsman M; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands. m.hulsman1@amsterdamumc.nl.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands. m.hulsman1@amsterdamumc.nl.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands. m.hulsman1@amsterdamumc.nl.; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands. m.hulsman1@amsterdamumc.nl., Charbonnier C; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ, Rouen, France., Grenier-Boley B; Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Quenez O; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ, Rouen, France., Grozeva D; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., van Rooij JGJ; Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands., Sims R; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Ahmad S; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands.; Leiden Academic Centre for Drug Research, Leiden, the Netherlands., Amin N; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands.; Nuffield Department of Population Health Oxford University, Oxford, UK., Norsworthy PJ; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, UK., Dols-Icardo O; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Research Networking Center on Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Hummerich H; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, UK., Kawalia A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Amouyel P; Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Beecham GW; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Berr C; Université Montpellier, INSERM, Institute for Neurosciences of Montpellier, Montpellier, France., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Boland A; Université Paris-Saclay, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Centre National de Recherche en Génomique Humaine Evry, Gif-sur-Yvette, France., Bossù P; Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy., Bouwman F; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Bras J; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.; Division of Psychiatry and Behavioral Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, USA., Campion D; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ, Rouen, France., Cochran JN; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Daniele A; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy., Dartigues JF; Université Bordeaux, INSERM, Bordeaux Population Health Research Center, Bordeaux, France., Debette S; Université Bordeaux, INSERM, Bordeaux Population Health Research Center, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital, Bordeaux, France., Deleuze JF; Université Paris-Saclay, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Centre National de Recherche en Génomique Humaine Evry, Gif-sur-Yvette, France., Denning N; UKDRI Cardiff, School of Medicine, Cardiff University, Cardiff, UK., DeStefano AL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Farrer LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University, Boston, MA, USA., Fernández MV; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.; Psychiatry Department, Washington University School of Medicine, St Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA., Fox NC; Dementia Research Centre, University College London Queen Square Institute of Neurology, London, UK., Galimberti D; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda, Ospedale Policlinico, Milan, Italy.; University of Milan, Milan, Italy., Genin E; Université Brest, INSERM, Etablissement Français du Sang, Centre Hospitalier Universitaire Brest, Unité Mixte de Recherche 1078, GGB, Brest, France., Gille JJP; Genome Diagnostics, Department of Human Genetics, VU University, AmsterdamUMC (location VUmc), Amsterdam, the Netherlands., Le Guen Y; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Guerreiro R; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.; Division of Psychiatry and Behavioral Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, USA., Haines JL; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA., Holmes C; Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK., Ikram MA; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands., Ikram MK; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands., Jansen IE; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Kraaij R; Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands., Lathrop M; McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada., Lemstra AW; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Lleó A; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Research Networking Center on Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Luckcuck L; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Mannens MMAM; Department of Human Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands., Marshall R; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Martin ER; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA., Masullo C; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Meggy A; UKDRI Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Mol MO; Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands., Morgan K; Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK., Myers RM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Naj AC; Penn Neurodegeneration Genomics Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Napolioni V; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.; Genomic and Molecular Epidemiology Laboratory, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy., Pasquier F; Université Lille, INSERM, Centre Hospitalier Universitaire Lille, UMR1172, Resources and Research Memory Center (MRRC) of Distalz, Licend, Lille, France., Pastor P; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Barcelona, Spain., Pericak-Vance MA; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA., Raybould R; UKDRI Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Redon R; Université de Nantes, Centre Hospitalier Universitaire Nantes, Centre National de la Recherche Scientifique, INSERM, l'institut du Thorax, Nantes, France., Reinders MJT; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands., Richard AC; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ, Rouen, France., Riedel-Heller SG; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Rivadeneira F; Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands., Rousseau S; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ, Rouen, France., Ryan NS; Dementia Research Centre, University College London Queen Square Institute of Neurology, London, UK., Saad S; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Sanchez-Juan P; Biomedical Research Networking Center on Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Scheltens P; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Schott JM; Dementia Research Centre, University College London Queen Square Institute of Neurology, London, UK., Seripa D; Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Lecce, Italy., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Sie D; Genome Diagnostics, Department of Human Genetics, VU University, AmsterdamUMC (location VUmc), Amsterdam, the Netherlands., Sistermans EA; Genome Diagnostics, Department of Human Genetics, VU University, AmsterdamUMC (location VUmc), Amsterdam, the Netherlands., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., van Spaendonk R; Genome Diagnostics, Department of Human Genetics, VU University, AmsterdamUMC (location VUmc), Amsterdam, the Netherlands., Spalletta G; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy., Tesi N; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands., Tijms B; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands., van der Lee SJ; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands., Visser PJ; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands., Wagner M; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany., Wallon D; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Neurology and CNRMAJ, Rouen, France., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Zarea A; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Neurology and CNRMAJ, Rouen, France., Clarimon J; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Research Networking Center on Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., van Swieten JC; Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands., Greicius MD; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Yokoyama JS; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Cruchaga C; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.; Psychiatry Department, Washington University School of Medicine, St Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA., Hardy J; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, University College London Institute of Neurology, London, UK., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany., Mead S; Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, UK., van der Flier WM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., van Duijn CM; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands.; Nuffield Department of Population Health Oxford University, Oxford, UK., Williams J; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics,, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Nicolas G; Université Rouen Normandie, INSERM U1245 and CHU Rouen, Department of Genetics and CNRMAJ, Rouen, France. gaelnicolas@hotmail.com., Bellenguez C; Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Lambert JC; Université Lille, INSERM, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. jean-charles.lambert@pasteur-lille.fr.

Publikováno v: Nature genetics [Nat Genet] 2022 Dec; Vol. 54 (12), pp. 1786-1794. Date of Electronic Publication: 2022 Nov 21.