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The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.

Autor: van Kempen LC; Department of Pathology, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada., Redpath M; Department of Pathology, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada., Elchebly M; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada., Klein KO; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada., Papadakis AI; Department of Pathology, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada., Wilmott JS; Melanoma Institute Australia, Royal Prince Alfred Hospital, and University of Sydney, Sydney, New South Wales, Australia., Scolyer RA; Melanoma Institute Australia, Royal Prince Alfred Hospital, and University of Sydney, Sydney, New South Wales, Australia., Edqvist PH; Department of Immunology, Genetics and Pathology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Pontén F; Department of Immunology, Genetics and Pathology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Schadendorf D; Department of Dermatology, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., van Rijk AF; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada., Michiels S; Service de Biostatistique et d'Epidémiologie, Gustave Roussy, Villejuif, France.; Centre for Research in Epidemiology and Population Health (CESP), INSERM, UMR 1018, Université Paris-Sud, Kremlin-Bicetre, France., Dumay A; Centre de Recherche sur l'Inflammation, INSERM, UMR S 1149, Labex Inflamex, Université Paris-Diderot Sorbonne Paris-Cité, Paris, France., Helbling-Leclerc A; CNRS, UMR 8200, Université Paris-Sud, Villejuif, France.; CNRS UMR 8200, Universite Paris-Sud, Gustave Roussy, Villejuif, France., Dessen P; Hématopoïèse normale et pathologique, INSERM UMR 1170, Université Paris-Sud, Gustave Roussy, Villejuif, France., Wouters J; Laboratory of Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium.; Laboratory of Computational Biology, VIB Center for the Biology of Disease, KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Stass M; Department of Surgical Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium., Greenwood CM; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.; Department of Oncology, McGill University, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada., Ghanem GE; Laboratory of Oncology and Experimental Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., van den Oord J; Laboratory of Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium., Feunteun J; CNRS UMR 8200, Universite Paris-Sud, Gustave Roussy, Villejuif, France., Spatz A; Department of Pathology, McGill University, Montreal, Quebec, Canada. alan.spatz@mcgill.ca.; Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.; Department of Oncology, McGill University, Montreal, Quebec, Canada.

Publikováno v: Science translational medicine [Sci Transl Med] 2016 Dec 14; Vol. 8 (369), pp. 369ra177.