LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.

Autor: Cobo-Vuilleumier N; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Rodríguez-Fernandez S; Immunology Department, Germans Trias i Pujol Research Institute, Autonomous University of Barcelona, Badalona, Spain., López-Noriega L; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Lorenzo PI; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Franco JM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Lachaud CC; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Vazquez EM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium., Legido RA; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Dorronsoro A; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., López-Férnandez-Sobrino R; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Fernández-Santos B; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Serrano CE; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Salas-Lloret D; Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., van Overbeek N; Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Ramos-Rodriguez M; Pompeu Fabra University, Barcelona, Spain., Mateo-Rodríguez C; Department of Endocrinology and Nutrition, University Hospital Virgen Macarena, Sevilla, Spain., Hidalgo L; Department of Endocrinology and Nutrition, University Hospital Virgen Macarena, Sevilla, Spain., Marin-Canas S; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium., Nano R; Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy., Arroba AI; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Caro AC; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Vertegaal AC; Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Montalvo AM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Martín F; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Aguilar-Diosdado M; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Piemonti L; Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy., Pasquali L; Pompeu Fabra University, Barcelona, Spain., Prieto RG; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Department of Cell Biology, Faculty of Biology, University of Sevilla, Sevilla, Spain., Sánchez MIG; Biobank of the Andalusian Public Health System, Node Hospital Virgen Macarena, Sevilla, Spain., Eizirik DL; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium., Martínez-Brocca MA; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Vives-Pi M; Immunology Department, Germans Trias i Pujol Research Institute, Autonomous University of Barcelona, Badalona, Spain., Gauthier BR; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2024 Dec; Vol. 14 (12), pp. e70134.