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pro vyhledávání: '"van Oosten Hawle P"'
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114279- (2024)
Summary: Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular intestinal infection and proteotoxic stress and that promotes
Externí odkaz:
https://doaj.org/article/03e70fa83e584fe39686fbea296078b7
Akademický článek
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Autor:
Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 3
Externí odkaz:
https://doaj.org/article/795dea3b15b941688aa5f281361c1332
Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging
Autor:
Patricija van Oosten-Hawle
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Aging results in a decline of cellular proteostasis capacity which culminates in the accumulation of phototoxic material, causing the onset of age-related maladies and ultimately cell death. Mechanisms that regulate proteostasis such as cellular stre
Externí odkaz:
https://doaj.org/article/c0d45f07f7c94aa3bba8e903bf0b7506
Autor:
Jay Miles, Sarah Townend, Dovilė Milonaitytė, William Smith, Francesca Hodge, David R Westhead, Patricija van Oosten-Hawle
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001605 (2023)
Organismal proteostasis is maintained by intercellular signaling processes including cell nonautonomous stress responses such as transcellular chaperone signaling (TCS). When TCS is activated upon tissue-specific knockdown of hsp-90 in the Caenorhabd
Externí odkaz:
https://doaj.org/article/31afc7953d3e40c8b78ef20e50d25213
Akademický článek
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Publikováno v:
Frontiers in Aging, Vol 3 (2022)
In multicellular organisms such as Caenorhabditis elegans, cellular stress stimuli and responses are communicated between tissues to promote organismal health- and lifespan. The nervous system is the predominant regulator of cell nonautonomous proteo
Externí odkaz:
https://doaj.org/article/6f14b9fa8dce49edae4d4d294044d308
Akademický článek
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Autor:
Rachel E. Lackie, Jose Marques-Lopes, Valeriy G. Ostapchenko, Sarah Good, Wing-Yiu Choy, Patricija van Oosten-Hawle, Stephen H. Pasternak, Vania F. Prado, Marco A. M. Prado
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Molecular chaperones and co-chaperones, which are part of the protein quality control machinery, have been shown to regulate distinct aspects of Alzheimer’s Disease (AD) pathology in multiple ways. Notably, the co-chaperone STI1, which pre
Externí odkaz:
https://doaj.org/article/9ee481f80095427e8c20de5968f11484
Autor:
Patricija van Oosten-Hawle
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 251 (2023)
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that assists in the maturation of many client proteins involved in cellular signal transduction. As a regulator of cellular signaling processes, it is vital for the maintenance o
Externí odkaz:
https://doaj.org/article/91fc8439cd8541c49054729e44bde5cf