Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53

Autor: Frank M. Riemers, van Liere Ea, Bart Westendorp, Hendrika A. Segeren, de Bruin A

Cancer cells often experience high basal levels of DNA replication stress (RS), for example due to hyperactivation of oncoproteins like MYC or RAS. Therefore, cancer cells are considered to be sensitive to drugs that exacerbate the level of RS or blo

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https://doi.org/10.1101/2021.06.14.448289

Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53.

Autor: Segeren HA; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., van Liere EA; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Riemers FM; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., de Bruin A; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Westendorp B; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. b.westendorp@uu.nl.

Publikováno v: Oncogene [Oncogene] 2022 May; Vol. 41 (19), pp. 2719-2733. Date of Electronic Publication: 2022 Apr 07.

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice.

Autor: Moreno E; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Toussaint MJM; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., van Essen SC; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Bongiovanni L; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., van Liere EA; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Koster MH; Division Molecular Genetics, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Yuan R; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.; Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands., van Deursen JM; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN.; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN., Westendorp B; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., de Bruin A; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.; Division Molecular Genetics, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2021 Jan; Vol. 73 (1), pp. 303-317.

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.

Autor: Sladky VC; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Knapp K; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Soratroi C; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Heppke J; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Eichin F; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Rocamora-Reverte L; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Szabo TG; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Bongiovanni L; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands., Westendorp B; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands., Moreno E; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands., van Liere EA; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands., Bakker B; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands., Spierings DCJ; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands., Wardenaar R; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands., Pereyra D; Department of Surgery, Medical University of Vienna, General Hospital, 1090 Vienna, Austria., Starlinger P; Department of Surgery, Medical University of Vienna, General Hospital, 1090 Vienna, Austria., Schultze S; Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, 1090 Vienna, Austria., Trauner M; Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, 1090 Vienna, Austria., Stojakovic T; Medical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, 8010 Graz, Austria., Scharnagl H; Medical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, 8010 Graz, Austria., Fava LL; Armenise-Harvard Laboratory of Cell Division, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, 38123 Povo, Italy., Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands., de Bruin A; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, the Netherlands; Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands., Villunger A; Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Electronic address: andreas.villunger@i-med.ac.at.

Publikováno v: Developmental cell [Dev Cell] 2020 Feb 10; Vol. 52 (3), pp. 335-349.e7. Date of Electronic Publication: 2020 Jan 23.

Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.

Autor: Boekhout M; Division of Cell Biology I (B5), The Netherlands Cancer Institute (NKI-AvL), Amsterdam, The Netherlands., Yuan R; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Wondergem AP; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Segeren HA; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., van Liere EA; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Awol N; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Jansen I; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Wolthuis RM; Division of Cell Biology I (B5), The Netherlands Cancer Institute (NKI-AvL), Amsterdam, The Netherlands., de Bruin A; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands Department of Pediatrics, Division of Molecular Genetics, University Medical Center Groningen University of Groningen, Groningen, The Netherlands a.debruin@uu.nl b.westendorp@uu.nl., Westendorp B; Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands a.debruin@uu.nl b.westendorp@uu.nl.

Publikováno v: EMBO reports [EMBO Rep] 2016 Mar; Vol. 17 (3), pp. 414-27. Date of Electronic Publication: 2016 Feb 05.