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Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.

Autor: Mlecnik B; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.; Inovarion, Paris, France., Bifulco C; Department of Pathology, Providence Portland Medical Center, Portland, OR., Bindea G; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France., Marliot F; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France., Lugli A; Institute of Pathology, University of Bern, Bern, Switzerland., Lee JJ; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX., Zlobec I; Institute of Pathology, University of Bern, Bern, Switzerland., Rau TT; Institute of Pathology, University of Bern, Bern, Switzerland., Berger MD; Department of Medical Oncology, University Hospital of Bern, Bern, Switzerland., Nagtegaal ID; Department of Pathology, Radboud Institute of Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands., Vink-Börger E; Department of Pathology, Radboud Institute of Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands., Hartmann A; Department of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Geppert C; Department of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Kolwelter J; Department of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Merkel S; Department of Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Grützmann R; Department of Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Van den Eynde M; Institut Roi Albert II, Department of Medical Oncology Cliniques Universitaires St-Luc and Institut de Recherche Clinique et Experimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium., Jouret-Mourin A; Department of Pathology, Cliniques Universitaires St-Luc and Institut de Recherche Clinique et Experimentale (Pole GAEN), Université Catholique de Louvain, Brussels, Belgium., Kartheuser A; Institut Roi Albert II, Department of Digestive Surgery, Cliniques Universitaires St-Luc Université Catholique de Louvain, Brussels, Belgium., Léonard D; Institut Roi Albert II, Department of Digestive Surgery, Cliniques Universitaires St-Luc Université Catholique de Louvain, Brussels, Belgium., Remue C; Institut Roi Albert II, Department of Digestive Surgery, Cliniques Universitaires St-Luc Université Catholique de Louvain, Brussels, Belgium., Wang JY; Curandis Laboratories, Boston, MA.; Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Bavi P; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Roehrl MHA; Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY., Ohashi PS; Princess Margaret Cancer Centre, UHN, Toronto, Ontario, Canada., Nguyen LT; Princess Margaret Cancer Centre, UHN, Toronto, Ontario, Canada., Han S; Princess Margaret Cancer Centre, UHN, Toronto, Ontario, Canada., MacGregor HL; Princess Margaret Cancer Centre, UHN, Toronto, Ontario, Canada., Hafezi-Bakhtiari S; Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada., Wouters BG; Princess Margaret Cancer Centre, UHN, Toronto, Ontario, Canada., Masucci GV; Department of Oncology-Pathology, Karolinska Institutet, Karolinska University, Stockholm, Sweden., Andersson EK; Department of Oncology-Pathology, Karolinska Institutet, Karolinska University, Stockholm, Sweden., Zavadova E; Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Vocka M; Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Spacek J; Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Petruzelka L; Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Konopasek B; Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Dundr P; Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Skalova H; Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Nemejcova K; Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic., Botti G; Department of Pathology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy., Tatangelo F; Department of Pathology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy., Delrio P; Colorectal Surgery Department, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy., Ciliberto G; IRCCS Istituto Nazionale Tumori 'Regina Elena', Rome, Italy., Maio M; Center for Immuno-Oncology, University Hospital, Siena, Italy., Laghi L; Department of Medicine and Surgery, University of Parma, and Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy., Grizzi F; Department of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Milan, Italy and Humanitas University, Rozzano, Milan, Italy., Fredriksen T; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France., Buttard B; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France., Lafontaine L; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France., Bruni D; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France., Lanzi A; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France., El Sissy C; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France., Haicheur N; Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France., Kirilovsky A; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France., Berger A; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.; Digestive Surgery Department, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France., Lagorce C; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.; Department of Pathology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France., Paustian C; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR., Ballesteros-Merino C; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR., Dijkstra J; Department of Pathology, Radboud Institute of Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands., van de Water C; Department of Pathology, Radboud Institute of Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands., van Lent-van Vliet S; Department of Pathology, Radboud Institute of Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands., Knijn N; Department of Pathology, Radboud Institute of Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands., Muşină AM; University of Medicine and Pharmacy 'Grigore T. Popa' Iaşi, Department of Surgical Oncology, Regional Institute of Oncology, Iaşi, Romania., Scripcariu DV; University of Medicine and Pharmacy 'Grigore T. Popa' Iaşi, Department of Surgical Oncology, Regional Institute of Oncology, Iaşi, Romania., Popivanova B; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan., Xu M; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan., Fujita T; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan., Hazama S; Department of Translational Research and Developmental Therapeutics against Cancer, Yamaguchi University School of Medicine, Yamaguchi, Japan., Suzuki N; Department of Gastroenterological, Breast, and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan., Nagano H; Department of Gastroenterological, Breast, and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan., Okuno K; Department of Surgery, Kindai University, School of Medicine, Osaka-sayama, Japan., Torigoe T; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Sato N; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Furuhata T; Department of Surgery, Surgical Oncology, and Science, Sapporo Medical University School of Medicine, Sapporo, Japan., Takemasa I; Department of Surgery, Surgical Oncology, and Science, Sapporo Medical University School of Medicine, Sapporo, Japan., Itoh K; Department of Immunology and Immunotherapy, Kurume University School of Medicine, Kurume, Japan., Patel PS; The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India., Vora HH; The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India., Shah B; The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India., Patel JB; The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India., Rajvik KN; The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India., Pandya SJ; The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India., Shukla SN; The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India., Wang Y; Institute of Cancer Research, Center of Translational Medicine, Health Science Center of Xi'an Jiaotong University, Xian, China., Zhang G; Institute of Cancer Research, Center of Translational Medicine, Health Science Center of Xi'an Jiaotong University, Xian, China., Kawakami Y; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan., Marincola FM; Refuge Biotechnologies, Menlo Park, CA., Ascierto PA; Melanoma, Cancer Immunotherapy, and Innovative Therapies Unit, Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', Napoli, Italy., Fox BA; Department of Pathology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France.; Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, Portland, OR., Pagès F; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France., Galon J; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, France.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Nov 01; Vol. 38 (31), pp. 3638-3651. Date of Electronic Publication: 2020 Sep 08.