Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

Autor: Polishchuk EV, Concilli M, Iacobacci S, Chesi G, Pastore N, Piccolo P, Paladino S, Baldantoni D, van IJzendoorn SC, Chan J, Chang CJ, Amoresano A., Pane F, Pucci P, Tarallo A, PARENTI, GIANCARLO, Brunetti Pierri N, SETTEMBRE, CARMINE, BALLABIO, ANDREA, Polishchuk RS, PUCCI, PIETRO

Publikováno v: Polishchuk, EV; Concilli, M; Iacobacci, S; Chesi, G; Pastore, N; Piccolo, P; et al.(2014). Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis. Developmental Cell, 29(6), 686-700. doi: 10.1016/j.devcel.2014.04.033. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/92m522vn
Developmental cell, vol 29, iss 6
Developmental Cell
Developmental Cell, 29(6), 686-700. CELL PRESS

Summary Copper is an essential yet toxic metal and its overload causes Wilson disease, a disorder due to mutations in copper transporter ATP7B. To remove excess copper into the bile, ATP7B traffics toward canalicular area of hepatocytes. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3001cf06b5a20f92aa4694e6fbd140
http://www.escholarship.org/uc/item/92m522vn

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