Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice.

Autor: van Thiel BS; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., de Boer M; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., Ridwan Y; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Radiotherapy, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands., de Kleijnen MGJ; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van Vliet N; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Linden J; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., de Beer I; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van Heijningen PM; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., Vermeij WP; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Hoeijmakers JHJ; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.; Institute for Genome Stability in Aging and Disease, Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Danser AHJ; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Kanaar R; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Duncker DJ; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Pluijm I; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. i.vanderpluijm@erasmusmc.nl.; Department of Vascular Surgery, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. i.vanderpluijm@erasmusmc.nl., Essers J; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. j.essers@erasmusmc.nl.; Department of Vascular Surgery, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. j.essers@erasmusmc.nl.; Department of Radiotherapy, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. j.essers@erasmusmc.nl.

Publikováno v: Molecular imaging and biology [Mol Imaging Biol] 2024 Aug; Vol. 26 (4), pp. 628-637. Date of Electronic Publication: 2024 Mar 18.

Pre-Operative Fasting Provides Long Term Protection Against Chronic Renal Damage Induced by Ischaemia Reperfusion Injury in Wild Type and Aneurysm Prone Fibulin-4 Mice.

Autor: Saat TC; Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., van der Pluijm I; Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands., Ridwan Y; Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., van Damme-van den Engel S; Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., van Heijningen PM; Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands., Clahsen-van Groningen MC; Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands., Verhagen HJM; Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., IJzermans JNM; Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., Essers J; Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: j.essers@erasmusmc.nl., de Bruin RWF; Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: r.w.f.debruin@erasmusmc.nl.

Publikováno v: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2020 Dec; Vol. 60 (6), pp. 905-915. Date of Electronic Publication: 2020 Oct 05.

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.

Autor: van der Pluijm I; Department of Vascular Surgery, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands.; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Burger J; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., van Heijningen PM; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., IJpma A; Clinical Bioinformatics Unit, Department of Pathology, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., van Vliet N; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Milanese C; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Schoonderwoerd K; Department of Clinical Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Sluiter W; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Ringuette LJ; Department of Anatomy and Cell Biology, McGill University, Rue University, Montréal, QC H3A 0C7, Canada., Dekkers DHW; Proteomics Center, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Que I; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, ZA Leiden, The Netherlands., Kaijzel EL; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, ZA Leiden, The Netherlands., Te Riet L; Department of Vascular Surgery, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands.; Department of Pharmacology, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., MacFarlane EG; Department of Surgery, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD, USA., Das D; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., van der Linden R; Stem cell Institute, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Vermeij M; Department of Pathology, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Demmers JA; Proteomics Center, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Mastroberardino PG; Department of Molecular Genetics, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands., Davis EC; Department of Anatomy and Cell Biology, McGill University, Rue University, Montréal, QC H3A 0C7, Canada., Yanagisawa H; Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan., Dietz HC; Department of Surgery, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD, USA.; Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD, USA.; Division of Pediatric Cardiology, Department of Pediatrics, and Department of Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD, USA., Kanaar R; Department of Radiation Oncology, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands.; Department of Molecular Genetics, Oncode Institute, Erasmus MC, Rotterdan, The Netherlands., Essers J; Department of Vascular Surgery, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands.; Department of Radiation Oncology, Erasmus MC, Wytemaweg 80, CN Rotterdam, The Netherlands.; Department of Molecular Genetics, Oncode Institute, Erasmus MC, Rotterdan, The Netherlands.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2018 Nov 01; Vol. 114 (13), pp. 1776-1793.

AT1-receptor blockade, but not renin inhibition, reduces aneurysm growth and cardiac failure in fibulin-4 mice.

Autor: Te Riet L; aDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine bDepartment of Vascular Surgery cDepartment of Genetics dDepartment of Cardiology eDepartment of Pathology fDepartment of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands., van Deel ED, van Thiel BS, Moltzer E, van Vliet N, Ridwan Y, van Veghel R, van Heijningen PM, Robertus JL, Garrelds IM, Vermeij M, van der Pluijm I, Danser AH, Essers J

Publikováno v: Journal of hypertension [J Hypertens] 2016 Apr; Vol. 34 (4), pp. 654-65.

Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.

Autor: Ramnath NW; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., van de Luijtgaarden KM; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., van der Pluijm I; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., van Nimwegen M; Department of Pulmonary Diseases, Erasmus MC, Rotterdam, The Netherlands., van Heijningen PM; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands., Swagemakers SM; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands; Department of Bioinformatics, Erasmus MC, Rotterdam, The Netherlands., van Thiel BS; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands; Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands., Ridwan RY; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands; Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands., van Vliet N; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands., Vermeij M; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands., Hawinkels LJ; Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden, The Netherlands., de Munck A; Department of Pediatric Surgery, Erasmus MC, Rotterdam, The Netherlands., Dzyubachyk O; Department of Medical Informatics and Department of Radiology, Erasmus MC, Rotterdam, The Netherlands; Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands., Meijering E; Department of Medical Informatics and Department of Radiology, Erasmus MC, Rotterdam, The Netherlands., van der Spek P; Department of Bioinformatics, Erasmus MC, Rotterdam, The Netherlands., Rottier R; Department of Pediatric Surgery, Erasmus MC, Rotterdam, The Netherlands., Yanagisawa H; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America., Hendriks RW; Department of Pulmonary Diseases, Erasmus MC, Rotterdam, The Netherlands., Kanaar R; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands; Department of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands., Rouwet EV; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., Kleinjan A; Department of Pulmonary Diseases, Erasmus MC, Rotterdam, The Netherlands., Essers J; Department of Genetics, Cancer Genomics Centre, Erasmus MC, Rotterdam, The Netherlands; Department of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.

Publikováno v: PloS one [PLoS One] 2014 Sep 25; Vol. 9 (9), pp. e106054. Date of Electronic Publication: 2014 Sep 25 (Print Publication: 2014).