Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability.

Autor: van Gorp RH; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.; Nattopharma ASA, Olso, Norway., Baaten CCFMJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.; Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany., Habibi A; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Jaminon AMG; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Peeters FECM; Department of Cardiology, MUMC+ and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Leenders P; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Crijns HJGMC; Department of Cardiology, MUMC+ and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Heemskerk JWM; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Reutelingsperger CP; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Spronk HM; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Schurgers LJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Publikováno v: European heart journal open [Eur Heart J Open] 2021 Aug 06; Vol. 1 (2), pp. oeab017. Date of Electronic Publication: 2021 Aug 06 (Print Publication: 2021).

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate.

Autor: van Gorp RH; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Nattopharma ASA, Oslo, Norway., Dijkgraaf I; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Bröker V; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Bauwens M; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands., Leenders P; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Jennen D; Department of Toxicogenomics, GROW School of Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Dweck MR; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Bucerius J; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands., Briedé JJ; Department of Toxicogenomics, GROW School of Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., van Ryn J; Department of Cardiometabolic Research, Boehringer Ingelheim, Biberach, Germany., Brandenburg V; Klinik Für Kardiologie und Nephrologie, Rhein-Maas Klinikum Würselen, Würselen, Germany., Mottaghy F; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.; Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany., Spronk HMH; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Reutelingsperger CP; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Schurgers LJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 May; Vol. 19 (5), pp. 1348-1363. Date of Electronic Publication: 2021 Mar 28.

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

Autor: Spronk HMH; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Padro T; Cardiovascular Research Center (ICCC), Hospital Sant Pau, Barcelona, Spain., Siland JE; Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands., Prochaska JH; Center for Cardiology/Center for Thrombosis and Hemostasis/DZHK, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Winters J; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., van der Wal AC; Department of Pathology, Academic Medical Center (AMC), Amsterdam, The Netherlands., Posthuma JJ; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Lowe G; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland., d'Alessandro E; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.; Department of Pathology, Academic Medical Center (AMC), Amsterdam, The Netherlands., Wenzel P; Department of Cardiology, Universitätsmedizin Mainz, Mainz, Germany., Coenen DM; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Reitsma PH; Einthoven Laboratory, Leiden University Medical Center, Leiden, The Netherlands., Ruf W; Center for Cardiology/Center for Thrombosis and Hemostasis/DZHK, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., van Gorp RH; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Koenen RR; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Vajen T; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Alshaikh NA; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Wolberg AS; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, United States., Macrae FL; Thrombosis and Tissue Repair Group, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK., Asquith N; Thrombosis and Tissue Repair Group, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK., Heemskerk J; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Heinzmann A; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Moorlag M; Synapse, Maastricht, The Netherlands., Mackman N; Department of Medicine, UNC McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, United States., van der Meijden P; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Meijers JCM; Department of Plasma Proteins, Sanquin, Amsterdam, The Netherlands., Heestermans M; Einthoven Laboratory, Leiden University Medical Center, Leiden, The Netherlands., Renné T; Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden.; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Dólleman S; Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands., Chayouâ W; Synapse, Maastricht, The Netherlands., Ariëns RAS; Thrombosis and Tissue Repair Group, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK., Baaten CC; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Nagy M; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Kuliopulos A; Tufts University School of Graduate Biomedical Sciences, Biochemistry/Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts., Posma JJ; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Harrison P; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom., Vries MJ; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Crijns HJGM; Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Dudink EAMP; Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Buller HR; Department of Vascular Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands., Henskens YMC; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Själander A; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Zwaveling S; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.; Synapse, Maastricht, The Netherlands., Erküner O; Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Eikelboom JW; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Gulpen A; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Peeters FECM; Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Douxfils J; Department of Pharmacy, Thrombosis and Hemostasis Center, Faculty of Medicine, Namur University, Namur, Belgium., Olie RH; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Baglin T; Department of Haematology, Addenbrookes Hospital Cambridge, Cambridge, United Kingdom., Leader A; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.; Davidoff Cancer Center, Rabin Medical Center, Institute of Hematology, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Tel Aviv, Israel., Schotten U; Center for Cardiology/Center for Thrombosis and Hemostasis/DZHK, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Scaf B; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., van Beusekom HMM; Department of Experimental Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands., Mosnier LO; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States., van der Vorm L; Synapse, Maastricht, The Netherlands., Declerck P; Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium., Visser M; Bayer AG, Wuppertal, Germany., Dippel DWJ; Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Strijbis VJ; Synapse, Maastricht, The Netherlands., Pertiwi K; Department of Cardiovascular Pathology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands., Ten Cate-Hoek AJ; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands., Ten Cate H; Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.

Publikováno v: Thrombosis and haemostasis [Thromb Haemost] 2018 Feb; Vol. 118 (2), pp. 229-250. Date of Electronic Publication: 2018 Jan 29.

Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep.

Autor: Nikiforou M; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands., Kemp MW; School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia., van Gorp RH; Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands.; School of Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Saito M; School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia.; Division of Perinatal Medicine, Tohoku University Hospital, Sendai, Japan., Newnham JP; School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia., Reynaert NL; School for Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands., Janssen LE; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands., Jobe AH; School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia.; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Centre, University of Cincinnati School of Medicine, Cincinnati, OH, USA., Kallapur SG; School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia.; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Centre, University of Cincinnati School of Medicine, Cincinnati, OH, USA., Kramer BW; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands.; School of Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Wolfs TG; Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands.; School of Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2016 Jan; Vol. 96 (1), pp. 69-80. Date of Electronic Publication: 2015 Oct 26.

Prevention of vasculopathy by vitamin K supplementation: can we turn fiction into fact?

Autor: Brandenburg VM; Department of Cardiology, University Hospital of the RWTH Aachen, Germany. Electronic address: VMBrandenburg@aol.com., Schurgers LJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Kaesler N; Department of Nephrology, University Hospital of the RWTH Aachen, Germany., Püsche K; Department of Cardiology, University Hospital of the RWTH Aachen, Germany., van Gorp RH; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands., Leftheriotis G; Department of Physiology and Vascular Investigation, Medical School and University Hospital of Angers, Angers, France., Reinartz S; Department of Radiology, University Hospital of the RWTH Aachen, Germany., Koos R; Department of Cardiology, University Hospital of the RWTH Aachen, Germany., Krüger T; Department of Nephrology, University Hospital of the RWTH Aachen, Germany.

Publikováno v: Atherosclerosis [Atherosclerosis] 2015 May; Vol. 240 (1), pp. 10-6. Date of Electronic Publication: 2015 Feb 24.