Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath.

Autor: van Gent ME; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. Electronic address: M.E.van_Gent@lumc.nl., Kłodzińska SN; Center for Biopharmaceuticals and Biobarriers in Drug Delivery (BioDelivery), Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Severin M; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Ali M; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., van Doodewaerd BR; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Bos E; Electron Microscopy Facility, Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Koning RI; Electron Microscopy Facility, Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Drijfhout JW; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Nielsen HM; Center for Biopharmaceuticals and Biobarriers in Drug Delivery (BioDelivery), Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Nibbering PH; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Publikováno v: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2023 Aug; Vol. 52, pp. 102694. Date of Electronic Publication: 2023 Jun 30.

Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections.

Autor: van Gent ME; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van Baaren T; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Kłodzińska SN; Center for Biopharmaceuticals and Biobarriers in Drug Delivery (BioDelivery), Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark., Ali M; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Dolezal N; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van Doodewaerd BR; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bos E; Electron Microscopy Facility, Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., de Waal AM; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Koning RI; Electron Microscopy Facility, Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Drijfhout JW; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Nielsen HM; Center for Biopharmaceuticals and Biobarriers in Drug Delivery (BioDelivery), Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark., Nibbering PH; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Publikováno v: Pharmaceutics [Pharmaceutics] 2023 Jan 28; Vol. 15 (2). Date of Electronic Publication: 2023 Jan 28.

Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin.

Autor: van Gent ME; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Reijden TJK; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Lennard PR; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Pulmonology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Center for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK., de Visser AW; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Schonkeren-Ravensbergen B; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Dolezal N; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Cordfunke RA; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Drijfhout JW; Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Nibbering PH; Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Publikováno v: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2022 May 17; Vol. 11 (5). Date of Electronic Publication: 2022 May 17.

Amyloid-like Behavior of Site-Specifically Citrullinated Myelin Oligodendrocyte Protein (MOG) Peptide Fragments inside EBV-Infected B-Cells Influences Their Cytotoxicity and Autoimmunogenicity.

Autor: Araman C; Leiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands., van Gent ME; Leiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands., Meeuwenoord NJ; Leiden Institute of Chemistry and Department of Bioorganic Synthesis , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands., Heijmans N; Department of Immunobiology , Biomedical Primate Research Centre , 2288 GJ Rijswijk , The Netherlands., Marqvorsen MHS; Leiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands., Doelman W; Leiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands., Faber BW; Department of Parasitology , Biomedical Primate Research Centre , 2288 GJ Rijswijk , The Netherlands., 't Hart BA; Department of Immunobiology , Biomedical Primate Research Centre , 2288 GJ Rijswijk , The Netherlands.; Department of Neuroscience , University of Groningen, University Medical Centre , 9700 AB Groningen , The Netherlands., Van Kasteren SI; Leiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands.

Publikováno v: Biochemistry [Biochemistry] 2019 Feb 12; Vol. 58 (6), pp. 763-775. Date of Electronic Publication: 2019 Jan 14.