Výsledky vyhledávání - "van Gelderen EM"

Editorial & Opinion

Are QTc interval changes after meal intake a reasonable method to prove assay sensitivity in thorough QT studies?

Autor: Hnatkova K; Imperial College, London, England., Kowalski D; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA., Keirns JJ; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA., van Gelderen EM; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Europe B.V., Leiden, The Netherlands., Malik M; St. Paul's Cardiac Electrophysiology and Imperial College, London, England. Electronic address: marek.malik@btinternet.com.

Publikováno v: Journal of electrocardiology [J Electrocardiol] 2015 Mar-Apr; Vol. 48 (2), pp. 276-7. Date of Electronic Publication: 2015 Jan 06.

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Akademický článek

Reproducibility of QTc interval changes after meal intake.

Publikováno v: Journal of electrocardiology [J Electrocardiol] 2015 Mar-Apr; Vol. 48 (2), pp. 194-202. Date of Electronic Publication: 2015 Jan 08.

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Akademický článek

QTc changes after meal intake: sex differences and correlates.

Autor: Hnatkova K; Imperial College, London, UK., Kowalski D; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA., Keirns JJ; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA., van Gelderen EM; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Europe B.V., Leiden, The Netherlands., Malik M; St. Paul's Cardiac Electrophysiology and Imperial College, London, UK. Electronic address: marek.malik@btinternet.com.

Publikováno v: Journal of electrocardiology [J Electrocardiol] 2014 Nov-Dec; Vol. 47 (6), pp. 856-62. Date of Electronic Publication: 2014 Aug 02.

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Akademický článek

ICH E14-compatible holter bin method and its equivalence to individual heart rate correction in the assessment of drug-induced QT changes.

Autor: Malik M; St. Paul's Cardiac Electrophysiology, University of London, and Imperial College, London, UK., Hnatkova K, Kowalski D, Keirns JJ, Van Gelderen EM

Publikováno v: Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2014 Nov; Vol. 25 (11), pp. 1232-41. Date of Electronic Publication: 2014 Jun 11.

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Editorial & Opinion

Have individual QT/RR curvatures value in QT correction?

Autor: Malik M; St. Paul's Cardiac Electrophysiology, London, UK. Electronic address: marek.malik@btinternet.com., Hnatkova K; St. Paul's Cardiac Electrophysiology, London, UK., Kowalski D; Global Data Science, Astellas Pharma Global Development Inc., Northbrook, IL, USA., Keirns JJ; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, IL, USA., van Gelderen EM; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Europe B.V., Leiden, The Netherlands.

Publikováno v: Journal of electrocardiology [J Electrocardiol] 2014 May-Jun; Vol. 47 (3), pp. 386-91. Date of Electronic Publication: 2014 Jan 31.

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Akademický článek

QT/RR curvatures in healthy subjects: sex differences and covariates.

Autor: Malik M; St. Paul's Cardiac Electrophysiology, University of London, and Imperial College, London, United Kingdom;, Hnatkova K, Kowalski D, Keirns JJ, van Gelderen EM

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2013 Dec; Vol. 305 (12), pp. H1798-806. Date of Electronic Publication: 2013 Oct 25.

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Akademický článek

Relationship of QT interval variability to heart rate and RR interval variability.

Autor: Hnatkova K; St. Paul's Cardiac Electrophysiology, London, United Kingdom. Electronic address: katerina.hnatkova@btinternet.com., Kowalski D, Keirns JJ, van Gelderen EM, Malik M

Publikováno v: Journal of electrocardiology [J Electrocardiol] 2013 Nov-Dec; Vol. 46 (6), pp. 591-6. Date of Electronic Publication: 2013 Aug 09.

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Akademický článek

Evaluation of the Pharmacokinetic Interaction Between the β3 -Adrenoceptor Agonist Mirabegron and the Muscarinic Receptor Antagonist Solifenacin In Healthy Subjects.

Autor: Krauwinkel WJ; Astellas Pharma Europe BV, Leiderdorp, The Netherlands., Kerbusch VM; PharmAspire Consulting, Wijchen, The Netherlands., Meijer J; Astellas Pharma Europe BV, Leiderdorp, The Netherlands., Tretter R; Astellas Pharma Europe BV, Leiderdorp, The Netherlands., Strabach G; Société Générale de Surveillance (SGS), Paris, France., Van Gelderen EM; Astellas Pharma Europe BV, Leiderdorp, The Netherlands.

Publikováno v: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2013 Jul; Vol. 2 (3), pp. 255-63. Date of Electronic Publication: 2013 May 14.

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Akademický článek

Proarrhythmic safety of repeat doses of mirabegron in healthy subjects: a randomized, double-blind, placebo-, and active-controlled thorough QT study.

Autor: Malik M; St Paul's Cardiac Electrophysiology, London, UK., van Gelderen EM, Lee JH, Kowalski DL, Yen M, Goldwater R, Mujais SK, Schaddelee MP, de Koning P, Kaibara A, Moy SS, Keirns JJ

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2012 Dec; Vol. 92 (6), pp. 696-706. Date of Electronic Publication: 2012 Nov 14.

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Akademický článek

Importance of subject-specific QT/RR curvatures in the design of individual heart rate corrections of the QT interval.

Autor: Malik M; St Paul's Cardiac Electrophysiology, London, England. marek.malik@btinternet.com, Hnatkova K, Kowalski D, Keirns JJ, van Gelderen EM

Publikováno v: Journal of electrocardiology [J Electrocardiol] 2012 Nov-Dec; Vol. 45 (6), pp. 571-81. Date of Electronic Publication: 2012 Sep 20.

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