CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease

Autor: Deurloo, DT, van Berkel, MAT, van Esch, BCAM, Hofhuis, F, Nijkamp, FP, Oosterwegel, MA, van Oosterhout, AJM

Publikováno v: Clinical and Experimental Allergy, 33(9), 1297-1304. Wiley

Background The existence of a third B7-1/B7-2 receptor was postulated in a recent study using a novel mouse strain lacking both CD28 and CTLA4 (CD28/CTLA4(-/-)). Objective In the present study, it was investigated if T cell co-stimulation via the put

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Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology.

Autor: Roth-Walter F; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Adcock IM; Molecular Cell Biology Group, National Heart & Lung Institute, Imperial College London, London, UK., Benito-Villalvilla C; Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, Madrid, Spain., Bianchini R; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria., Bjermer L; Department of Respiratory Medicine and Allergology, Lung and Allergy research, Allergy, Asthma and COPD Competence Center, Lund University, Lund, Sweden., Caramori G; Department of Medicine and Surgery, University of Parma, Pneumologia, Italy., Cari L; Department of Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy., Chung KF; Experimental Studies Medicine at National Heart & Lung Institute, Imperial College London & Royal Brompton & Harefield Hospital, London, UK., Diamant Z; Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund, Sweden.; Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.; Department of Clinical Pharmacy & Pharmacology, University Groningen, University Medical Center Groningen and QPS-NL, Groningen, The Netherlands., Eguiluz-Gracia I; Allergy Unit, Hospital Regional Universitario de Málaga-Instituto de Investigación Biomédica de Málaga (IBIMA)-ARADyAL, Málaga, Spain., Knol EF; Departments of Center of Translational Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands., Jesenak M; Department of Paediatrics, Department of Pulmonology and Phthisiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, University Teaching Hospital, Martin, Slovakia., Levi-Schaffer F; Institute for Drug Research, Pharmacology Unit, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Nocentini G; Department of Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy., O'Mahony L; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Medicine, University College Cork, Cork, Ireland.; School of Microbiology, University College Cork, Cork, Ireland., Palomares O; Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, Madrid, Spain., Redegeld F; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Sokolowska M; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland.; Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland., Van Esch BCAM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Stellato C; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy.

Publikováno v: Allergy [Allergy] 2024 May; Vol. 79 (5), pp. 1089-1122. Date of Electronic Publication: 2023 Dec 18.

Dietary composition of adult eosinophilic esophagitis patients is related to disease severity.

Autor: Eussen SRBM; Danone Nutricia Research, Utrecht, The Netherlands., Wielders S; Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands., de Rooij WE; Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Van Ampting MTJ; Danone Nutricia Research, Utrecht, The Netherlands., Van Esch BCAM; Danone Nutricia Research, Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., de Vries JHM; Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands., Bredenoord AJ; Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Vlieg-Boerstra B; Department of Pediatrics, OLVG Hospital, Amsterdam, The Netherlands.

Publikováno v: Immunity, inflammation and disease [Immun Inflamm Dis] 2024 Mar; Vol. 12 (3), pp. e1206.

In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis.

Autor: Haasnoot ML; Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands., Kleuskens MTA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Lopez-Rincon A; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Department of Data Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Diks MAP; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Terreehorst I; Department of Ear Nose Throat, Amsterdam UMC, Amsterdam, The Netherlands., Akkerdaas JH; Department of Experimental Immunology, Amsterdam UMC, Amsterdam, The Netherlands., van Ree R; Department of Ear Nose Throat, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Experimental Immunology, Amsterdam UMC, Amsterdam, The Netherlands., van Ampting MTJ; Danone Nutricia Research, Utrecht, The Netherlands., Garssen J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Danone Nutricia Research, Utrecht, The Netherlands., Redegeld FA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., van Esch BCAM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Danone Nutricia Research, Utrecht, The Netherlands., Bredenoord AJ; Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands.

Publikováno v: Allergy [Allergy] 2023 Jul; Vol. 78 (7), pp. 2044-2047. Date of Electronic Publication: 2023 Mar 10.