Framework for Implementing Individualised Dosing of Anti-Cancer Drugs in Routine Care: Overcoming the Logistical Challenges.

Autor: van Leuven, Jason, Evans, Simon, Kichenadasse, Ganessan, Steeghs, Neeltje, Bonevski, Billie, Mikus, Gerd, van Dyk, Madelé

Publikováno v: Cancers; Jul2023, Vol. 15 Issue 13, p3293, 11p

The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia

Autor: Michelet, Robin, Ursino, Moreno, Boulet, Sandrine, Franck, Sebastian, Casilag, Fiordiligie, Baldry, Mara, Rolff, Jens, van Dyk, Madelé, Wicha, Sebastian, Sirard, Jean-Claude, Comets, Emmanuelle, Zohar, Sarah, Kloft, Charlotte

Publikováno v: Pharmaceutics
Pharmaceutics, 2021, 13 (5), pp.601. ⟨10.3390/pharmaceutics13050601⟩
Pharmaceutics, MDPI, 2021, 13 (5), pp.601. ⟨10.3390/pharmaceutics13050601⟩
Volume 13
Issue 5
Pharmaceutics, Vol 13, Iss 601, p 601 (2021)

International audience; The treatment of respiratory tract infections is threatened by the emergence of bacterial resistance. Immunomodulatory drugs, which enhance airway innate immune defenses, may improve therapeutic outcome. In this concept paper,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f3eced2285c88bd0176ee44f3c043fc
https://hal.sorbonne-universite.fr/hal-03215662

Evaluation of modafinil as a perpetrator of metabolic drug–drug interactions using a model informed cocktail reaction phenotyping trial protocol

Autor: Rowland, Angela, van Dyk, Madelé, Warncken, David, Mangoni, Arduino A., Sorich, Michael J., Rowland, Andrew

AIM: To evaluate the capacity for modafinil to be a perpetrator of metabolic drug–drug interactions by altering cytochrome P450 activity following a single dose and dosing to steady state. METHODS: A single centre, open label, single sequence cockt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc89e349089928955f6a9aa0346457cf
https://europepmc.org/articles/PMC5809348/

Validation of a 3-h Sampling Interval to Assess Variability in Cytochrome P450 3A Phenotype and the Impact of Induction and Mechanism-Based Inhibition Using Midazolam as a Probe Substrate.

Autor: van Dyk, Madelé, Kapetas, Asha J., Hopkins, Ashley M., Rodrigues, A. David, Vourvahis, Manoli, Sorich, Michael J., Rowland, Andrew

Publikováno v: Frontiers in Pharmacology; 9/27/2019, p1-11, 11p

Assessment of inter-racial variability in CYP3A4 activity and inducibility among healthy adult males of Caucasian and South Asian ancestries.

Autor: van Dyk, Madelé, Marshall, Jean-Claude, Sorich, Michael J, Wood, Linda S., Rowland, Andrew

Publikováno v: European Journal of Clinical Pharmacology; Jul2018, Vol. 74 Issue 7, p913-920, 8p, 3 Charts, 2 Graphs