Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms.

Autor: Botschuijver S; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., van Diest SA; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., van Thiel IAM; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Saia RS; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Strik AS; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Yu Z; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Department of Neurobiology, Tongji Medical College, HUST, Wuhan, People's Republic of China.; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China., Maria-Ferreira D; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, Brazil., Welting O; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Keszthelyi D; Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands., Jennings G; Business Development, Redivia, Technische Universität, Dresden, Germany., Heinsbroek SEM; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Elferink RPO; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Schuren FHJ; Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Zeist, The Netherlands., de Jonge WJ; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., van den Wijngaard RM; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands. R.vandenWijngaard@AMC.UVA.NL.; Department of Gastroenterology and Hepatology, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands. R.vandenWijngaard@AMC.UVA.NL.

Publikováno v: Scientific reports [Sci Rep] 2019 Aug 29; Vol. 9 (1), pp. 12530. Date of Electronic Publication: 2019 Aug 29.

Susceptibility to stress induced visceral hypersensitivity in maternally separated rats is transferred across generations.

Autor: van den Wijngaard RM; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands., Stanisor OI, van Diest SA, Welting O, Wouters MM, Cailotto C, de Jonge WJ, Boeckxstaens GE

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society [Neurogastroenterol Motil] 2013 Dec; Vol. 25 (12), pp. e780-90. Date of Electronic Publication: 2013 Aug 21.

Peripheral α-helical CRF (9-41) does not reverse stress-induced mast cell dependent visceral hypersensitivity in maternally separated rats.

Autor: van den Wijngaard RM; Tytgat Institute for Liver and Intestinal research, Academic Medical Center, Amsterdam, The Netherlands. r.vandenwijngaard@amc.uva.nl, Stanisor OI, van Diest SA, Welting O, Wouters MM, de Jonge WJ, Boeckxstaens GE

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society [Neurogastroenterol Motil] 2012 Mar; Vol. 24 (3), pp. 274-82, e111. Date of Electronic Publication: 2011 Nov 30.

Relevance of mast cell-nerve interactions in intestinal nociception.

Autor: van Diest SA; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands. s.a.vanDiest@AMC.UVA.NL, Stanisor OI, Boeckxstaens GE, de Jonge WJ, van den Wijngaard RM

Publikováno v: Biochimica et biophysica acta [Biochim Biophys Acta] 2012 Jan; Vol. 1822 (1), pp. 74-84. Date of Electronic Publication: 2011 Apr 07.