Measurement of Oxygen Metabolism In Vivo

Autor: van Diemen, MPJ, Ubbink, Rinse, Munker, FM, Mik, Bert, Groeneveld, GJ, Will, Y., Dykens, J.A.

Publikováno v: Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

This chapter explains the importance of measuring mitochondrial function in drug trials. It focuses on features of a novel Cellular Oxygen METabolism (COMET) measurement system: The first bedside monitor of cellular oxygen metabolism. It is apparent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4401a79aacc32ddada05680847f0b8cb
https://pure.eur.nl/en/publications/74f89e11-61a2-4b53-9105-627d9e34d4d2

Mitochondrial function, grip strength, and activity are related to recovery of mobility after a total knee arthroplasty.

Autor: van Diemen MPJ; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Orthopedics, Leiden University Medical Center, Leiden, The Netherlands., Ziagkos D; Centre for Human Drug Research, Leiden, The Netherlands., Kruizinga MD; Centre for Human Drug Research, Leiden, The Netherlands., Bénard MR; Department of Orthopedics, Alrijne Hospital, Leiden, The Netherlands., Lambrechtse P; Centre for Human Drug Research, Leiden, The Netherlands., Jansen JAJ; Department of Orthopedics, Alrijne Hospital, Leiden, The Netherlands., Snoeker BAM; Department of Clinical Epidemiology, Amsterdam Medical Centre, Amsterdam, The Netherlands., Gademan MGJ; Department of Orthopedics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Cohen AF; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands., Nelissen RGHH; Department of Orthopedics, Leiden University Medical Center, Leiden, The Netherlands., Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2023 Feb; Vol. 16 (2), pp. 224-235. Date of Electronic Publication: 2022 Nov 19.

Brain Bio-Energetic State Does Not Correlate to Muscle Mitochondrial Function in Huntington's Disease.

Autor: van Diemen MPJ; Centre for Human Drug Research, Leiden, The Netherlands., Hart EP; Centre for Human Drug Research, Leiden, The Netherlands., Hameeteman PW; Centre for Human Drug Research, Leiden, The Netherlands., Coppen EM; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Winder JY; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., den Heijer J; Centre for Human Drug Research, Leiden, The Netherlands., Moerland M; Centre for Human Drug Research, Leiden, The Netherlands., Kan H; Gorter Centre for High-field MRI, Leiden University Medical Center, Leiden, The Netherlands., van der Grond J; Radiology Research Center, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Webb A; Gorter Centre for High-field MRI, Leiden University Medical Center, Leiden, The Netherlands., Roos RAC; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands., Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Journal of Huntington's disease [J Huntingtons Dis] 2020; Vol. 9 (4), pp. 335-344.

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly.

Autor: Andreux PA; Amazentis SA, EPFL Innovation Park, Batiment C, CH-1015, Lausanne, Switzerland. contact@amazentis.com., van Diemen MPJ; Center for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Heezen MR; Center for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Auwerx J; Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland., Rinsch C; Amazentis SA, EPFL Innovation Park, Batiment C, CH-1015, Lausanne, Switzerland., Groeneveld GJ; Center for Human Drug Research, Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Singh A; Amazentis SA, EPFL Innovation Park, Batiment C, CH-1015, Lausanne, Switzerland.

Publikováno v: Scientific reports [Sci Rep] 2018 Jun 04; Vol. 8 (1), pp. 8548. Date of Electronic Publication: 2018 Jun 04.