Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices

Autor: Jetten MJ, Claessen SM, Dejong CH, Lahoz A, Castell JV, van Delft JH, Kleinjans JC

Publikováno v: Toxicology
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::18683015240d1d4d4b10db676aa84f7c
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2553

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Control of the tRNA-tufB operon in Escherichia coli. 3. Feedback inhibition of tufB expression by an EF-Tu with a deletion in the guanine-nucleotide-binding domain

Autor: Van Delft Jh, Bosch L

Publikováno v: European journal of biochemistry. 175(2)

The expression of tufB, one of the two EF-Tu-encoding genes in Escherichia coli, is under autogenous control. Feedback inhibition of tufB expression by plasmid-borne EF-Tu has been used to answer the question of whether or not the integrity of the gu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d391607c4a16808772838ef194d77d
https://pubmed.ncbi.nlm.nih.gov/2456928

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury.

Autor: Jiang J; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. Electronic address: j.jiang@maastrichtuniversity.nl., Mathijs K; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Timmermans L; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Claessen SM; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Hecka A; DSM Resolve, Geleen, The Netherlands., Weusten J; DSM Resolve, Geleen, The Netherlands., Peters R; Van 't Hoff Institute for Molecular Science (HIMS), Universiteit van Amsterdam, Amsterdam, The Netherlands; DSM Coating Resins, Waalwijk, The Netherlands., van Delft JH; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Kleinjans JCS; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Jennen DGJ; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., de Kok TM; Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2017 Oct 01; Vol. 332, pp. 100-108. Date of Electronic Publication: 2017 Jul 18.

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Autor: Jetten MJ; Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Room 4.112 UNS 50, 6229 ER, Maastricht, The Netherlands. marlon.jetten@maastrichtuniversity.nl., Ruiz-Aracama A; RIKILT, Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE, Wageningen, The Netherlands., Coonen ML; Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Room 4.112 UNS 50, 6229 ER, Maastricht, The Netherlands., Claessen SM; Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Room 4.112 UNS 50, 6229 ER, Maastricht, The Netherlands., van Herwijnen MH; Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Room 4.112 UNS 50, 6229 ER, Maastricht, The Netherlands., Lommen A; RIKILT, Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE, Wageningen, The Netherlands., van Delft JH; Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Room 4.112 UNS 50, 6229 ER, Maastricht, The Netherlands., Peijnenburg AA; RIKILT, Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE, Wageningen, The Netherlands., Kleinjans JC; Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Room 4.112 UNS 50, 6229 ER, Maastricht, The Netherlands.

Publikováno v: Archives of toxicology [Arch Toxicol] 2016 May; Vol. 90 (5), pp. 1103-15. Date of Electronic Publication: 2015 Jun 24.