An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Autor: Boldt, Karsten, van Reeuwijk, Jeroen, Dougherty, Gerard, Lamers, Ideke J C, Coene, Karlien L M, Arts, Heleen H, Betts, Matthew J, Beyer, Tina, Bolat, Emine, Gloeckner, Christian Johannes, Haidari, Khatera, Hetterschijt, Lisette, Lu, Qianhao, Iaconis, Daniela, Jenkins, Dagan, Klose, Franziska, Knapp, Barbara, Latour, Brooke, Letteboer, Stef J F, Marcelis, Carlo L, Mitic, Dragana, Morleo, Manuela, Oud, Machteld M, Koutroumpas, Konstantinos, Riemersma, Moniek, Rix, Susan, Terhal, Paulien A, Toedt, Grischa, van Dam, Teunis J P, de Vrieze, Erik, Wissinger, Yasmin, Wu, Ka Man, Apic, Gordana, Beales, Philip L, Nguyen, Thanh-Minh T, Blacque, Oliver E, Gibson, Toby J, Huynen, Martijn A, Katsanis, Nicholas, Kremer, Hannie, Omran, Heymut, van Wijk, Erwin, Wolfrum, Uwe, Kepes, François, Davis, Erica E, Texier, Yves, Franco, Brunella, Giles, Rachel H, Ueffing, Marius, Russell, Robert B, Roepman, Ronald, Group, UK10K Rare Diseases, Al-Turki, Saeed, Anderson, Carl, Antony, Dinu, Barroso, Inês, van Beersum, Sylvia E C, Bentham, Jamie, Bhattacharya, Shoumo, Carss, Keren, Chatterjee, Krishna, Cirak, Sebahattin, Cosgrove, Catherine, Danecek, Petr, Durbin, Richard, Fitzpatrick, David, Floyd, Jamie, Horn, Nicola, Reghan Foley, A., Franklin, Chris, Futema, Marta, Humphries, Steve E, Hurles, Matt, Joyce, Chris, McCarthy, Shane, Mitchison, Hannah M, Muddyman, Dawn, Muntoni, Francesco, Willer, Jason R, O'Rahilly, Stephen, Onoufriadis, Alexandros, Payne, Felicity, Plagnol, Vincent, Raymond, Lucy, Savage, David B, Scambler, Peter, Schmidts, Miriam, Schoenmakers, Nadia, Semple, Robert, Mans, Dorus A, Serra, Eva, Stalker, Jim, van Kogelenberg, Margriet, Vijayarangakannan, Parthiban, Walter, Klaudia, Whittall, Ros, Williamson, Kathy

Publikováno v: Nature Communications 7(1), 11491 (2016). doi:10.1038/ncomms11491
Boldt, K, Van Reeuwijk, J, Lu, Q, Koutroumpas, K, Nguyen, T M T, Texier, Y, Van Beersum, S E C, Horn, N, Willer, J R, Mans, D A, Dougherty, G, Lamers, I J C, Coene, K L M, Arts, H H, Betts, M J, Beyer, T, Bolat, E, Gloeckner, C J, Haidari, K, Hetterschijt, L, Iaconis, D, Jenkins, D, Klose, F, Knapp, B, Latour, B, Letteboer, S J F, Marcelis, C L, Mitic, D, Morleo, M, Oud, M M, Riemersma, M, Rix, S, Terhal, P A, Toedt, G, Van Dam, T J P, De Vrieze, E, Wissinger, Y, Wu, K M, Al-Turki, S, Anderson, C, Antony, D, Barroso, I, Bentham, J, Bhattacharya, S, Carss, K, Chatterjee, K, Cirak, S, Cosgrove, C, Danecek, P, Durbin, R, Fitzpatrick, D, Floyd, J, Foley, A R, Franklin, C, Futema, M, Humphries, S E, Hurles, M, Joyce, C, McCarthy, S, Mitchison, H M, Muddyman, D, Muntoni, F, O'Rahilly, S, Onoufriadis, A, Payne, F, Plagnol, V, Raymond, L, Savage, D B, Scambler, P, Schmidts, M, Schoenmakers, N, Semple, R, Serra, E, Stalker, J, Van Kogelenberg, M, Vijayarangakannan, P, Walter, K, Whittall, R, Williamson, K, Apic, G, Beales, P L, Blacque, O E, Gibson, T J, Huynen, M A, Katsanis, N, Kremer, H, Omran, H, Van Wijk, E, Wolfrum, U, Kepes, F, Davis, E E, Franco, B, Giles, R H, Ueffing, M, Russell, R B & Roepman, R 2016, ' An organelle-specific protein landscape identifies novel diseases and molecular mechanisms ', Nature Communications, vol. 7, 11491 . https://doi.org/10.1038/ncomms11491
Nat. Commun. 7:11491 (2016)
Nature Communications
Nature Communications, 7, 11491-11491
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 7, pp. 11491-11491

Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed822a01064aab67a40c84234dc2fc74
https://pub.dzne.de/record/138561

Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes.

Autor: Parga-Vidal L; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands. l.pargavidal@sanquin.nl k.vangisbergen@sanquin.nl., Behr FM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Kragten NAM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Nota B; Department of Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Wesselink TH; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Kavazović I; Department of Histology and Embryology, University of Rijeka, Rijeka, Croatia., Covill LE; Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden., Schuller MBP; Department of Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Bryceson YT; Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Brogelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway., Wensveen FM; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Histology and Embryology, University of Rijeka, Rijeka, Croatia., van Lier RAW; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., van Dam TJP; Department of Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Stark R; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; BIH Center for Regenerative Therapies, Charité Universitätsmedizin Berlin, Berlin, Germany., van Gisbergen KPJM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands. l.pargavidal@sanquin.nl k.vangisbergen@sanquin.nl.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Publikováno v: Science immunology [Sci Immunol] 2021 Aug 20; Vol. 6 (62).

Tissue-resident memory CD8 ⁺ T cells shape local and systemic secondary T cell responses.

Autor: Behr FM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Parga-Vidal L; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Kragten NAM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Dam TJP; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Department of Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Wesselink TH; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Sheridan BS; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Arens R; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands., van Lier RAW; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Stark R; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Gisbergen KPJM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. k.vangisbergen@sanquin.nl.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. k.vangisbergen@sanquin.nl.

Publikováno v: Nature immunology [Nat Immunol] 2020 Sep; Vol. 21 (9), pp. 1070-1081. Date of Electronic Publication: 2020 Jul 13.

Ciliary force-responsive striated fibers promote basal body connections and cortical interactions.

Autor: Soh AWJ; Anschutz Medical Campus, Department of Cell and Developmental Biology, University of Colorado, Aurora, CO., van Dam TJP; Theoretical Biology and Bioinformatics, Department of Biology, Science Faculty, Utrecht University, Utrecht, Netherlands., Stemm-Wolf AJ; Anschutz Medical Campus, Department of Cell and Developmental Biology, University of Colorado, Aurora, CO., Pham AT; Anschutz Medical Campus, Department of Cell and Developmental Biology, University of Colorado, Aurora, CO., Morgan GP; Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO., O'Toole ET; Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO., Pearson CG; Anschutz Medical Campus, Department of Cell and Developmental Biology, University of Colorado, Aurora, CO.

Publikováno v: The Journal of cell biology [J Cell Biol] 2020 Jan 06; Vol. 219 (1).

CiliaCarta: An integrated and validated compendium of ciliary genes.

Autor: van Dam TJP; Centre for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, the Netherlands.; Theoretical Biology and Bioinformatics, Science faculty, Utrecht University, Utrecht, the Netherlands., Kennedy J; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland., van der Lee R; Centre for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, the Netherlands., de Vrieze E; Department of Otorhinolaryngology, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Wunderlich KA; Molecular Cell Biology, Institute of Molecular Physiology, Johannes Gutenberg University of Mainz, Mainz, Germany., Rix S; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Dougherty GW; Department of General Pediatrics, University Hospital Muenster, Muenster, Germany., Lambacher NJ; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland.; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, British Columbia, Canada., Li C; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, British Columbia, Canada., Jensen VL; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, British Columbia, Canada., Leroux MR; Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, British Columbia, Canada., Hjeij R; Department of General Pediatrics, University Hospital Muenster, Muenster, Germany., Horn N; Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany., Texier Y; Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany., Wissinger Y; Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany., van Reeuwijk J; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Wheway G; Section of Ophthalmology & Neurosciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom., Knapp B; Molecular Cell Biology, Institute of Molecular Physiology, Johannes Gutenberg University of Mainz, Mainz, Germany., Scheel JF; Molecular Cell Biology, Institute of Molecular Physiology, Johannes Gutenberg University of Mainz, Mainz, Germany., Franco B; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Medical Genetics, Department of Translational Medicine, Federico II University of Naples, Naples, Italy., Mans DA; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van Wijk E; Department of Otorhinolaryngology, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Képès F; Institute of Systems and Synthetic Biology (iSSB), Genopole, CNRS, Univ. Evry, France., Slaats GG; Dept. Nephrology and Hypertension, Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, the Netherlands., Toedt G; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Kremer H; Department of Otorhinolaryngology, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Omran H; Department of General Pediatrics, University Hospital Muenster, Muenster, Germany., Szymanska K; Section of Ophthalmology & Neurosciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom., Koutroumpas K; Institute of Systems and Synthetic Biology (iSSB), Genopole, CNRS, Univ. Evry, France., Ueffing M; Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany., Nguyen TT; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Letteboer SJF; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Oud MM; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., van Beersum SEC; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Schmidts M; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Pediatric Genetics Division, Center for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany., Beales PL; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Lu Q; Biochemie Zentrum Heidelberg (BZH), Heidelberg University, Heidelberg, Germany.; Bioquant/Cell Networks, Heidelberg, Germany., Giles RH; Dept. Nephrology and Hypertension, Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, the Netherlands., Szklarczyk R; Centre for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, the Netherlands., Russell RB; Biochemie Zentrum Heidelberg (BZH), Heidelberg University, Heidelberg, Germany.; Bioquant/Cell Networks, Heidelberg, Germany., Gibson TJ; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Johnson CA; Section of Ophthalmology & Neurosciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom., Blacque OE; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland., Wolfrum U; Molecular Cell Biology, Institute of Molecular Physiology, Johannes Gutenberg University of Mainz, Mainz, Germany., Boldt K; Medical Proteome Center, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany., Roepman R; Department of Human Genetics and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Hernandez-Hernandez V; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Huynen MA; Centre for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, the Netherlands.

Publikováno v: PloS one [PLoS One] 2019 May 16; Vol. 14 (5), pp. e0216705. Date of Electronic Publication: 2019 May 16 (Print Publication: 2019).