Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes

Autor: Hesselink, Dennis A., van Gelder, Teun, van Schaik, Ron H. N., Balk, Aggie H. M. M., van der Heiden, Ilse P., van Dam, Thea, van der Werf, Marloes, Weimar, Willem, Mathot, Ron A. A.

Publikováno v: Clinical pharmacology and therapeutics, 76(6), 545-556. Wiley-Blackwell

Our objective was to determine the relationship between single nucleotide polymorphisms (SNPs) in the multidrug resistance 1 (MDR-1) gene and the cytochrome P450 (CYP) genes CYP3A4 and CYP3A5 and the pharmacokinetics of cyclosporine (INN, ciclosporin

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Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids.

Autor: Verhaar, Marianne C., Honing, Marina L.H., van Dam, Thea, Zwart, Mirjam, Koomans, Hein A., Kastelein, John J.P., Rabelink, Ton J.

Publikováno v: Cardiovascular Research; May1999, Vol. 42 Issue 3, p752-760, 9p

Tetrahydrobiopterin Regulates Superoxide and Nitric Oxide Generation by Recombinant Endothelial Nitric Oxide Synthase

Autor: Wever, Robert M.F., van Dam, Thea, van Rijn, Herman J.M., de Groot, Flip, Rabelink, Ton J.

Publikováno v: Biochemical and Biophysical Research Communications; August 1997, Vol. 237 Issue: 2 p340-344, 5p

Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes.

Autor: Hesselink DA; Department of Internal Medicine, Renal Transplant Unit, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands. d.a.hesselink@erasmusmc.nl, van Gelder T, van Schaik RH, Balk AH, van der Heiden IP, van Dam T, van der Werf M, Weimar W, Mathot RA

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2004 Dec; Vol. 76 (6), pp. 545-56.