Zobrazeno 1 - 10
of 21
pro vyhledávání: '"van Cc René Donkelaar"'
Autor:
van Cc René Donkelaar, W Wouter Wilson
Publikováno v:
Biomechanics and Modeling in Mechanobiology, 11(5), 655-664. Springer
Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9c5d5b62efe5bb0c30ac738e3e31a0
https://doi.org/10.1007/s10237-011-0340-0
https://doi.org/10.1007/s10237-011-0340-0
Publikováno v:
Osteoarthritis and Cartilage, 19(6), 676-682. W.B. Saunders Ltd
Objective There are strong indications that subchondral bone may play an important role in osteoarthritis (OA), making it an interesting target for medical therapies. The subchondral bone structure changes markedly during OA, and it has long been ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2632a76c3c2f9e3ed3a44f987b44ebc7
https://doi.org/10.1016/j.joca.2011.02.007
https://doi.org/10.1016/j.joca.2011.02.007
Publikováno v:
Journal of Biomechanics, 44(9), 1765-1770. Elsevier
During endochondral ossification, growth plate cartilage is replaced with bone. Mineralized cartilage matrix is resorbed by osteoclasts, and new bone tissue is formed by osteoblasts. As mineralized cartilage does not contain any cells, it is unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a00ce2ae2f28828d97600513d96e4f
https://doi.org/10.1016/j.jbiomech.2011.04.011
https://doi.org/10.1016/j.jbiomech.2011.04.011
Publikováno v:
Computer Methods in Biomechanics and Biomedical Engineering, 14(5), 425-432. Informa Healthcare
Extracellular matrix (ECM) in chondrocytes-seeded agarose aggregates to form islands of matrix. These islands need to coalesce to develop functional cartilage. Hence, macroscopic properties are determined by transport and aggregation of macromolecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbb7eae1f8e12be695339a336c2a26a
https://doi.org/10.1080/10255842.2011.554409
https://doi.org/10.1080/10255842.2011.554409
Autor:
A Agnese Ravetto, Jasper Foolen, Linda M. Kock, Keita Ito, Pieter J. Emans, van Cc René Donkelaar
Publikováno v:
Osteoarthritis and Cartilage, 18(11), 1528-1535. W.B. Saunders Ltd
Osteoarthritis and Cartilage, 18(11), 1528-1535. ELSEVIER SCI LTD
Osteoarthritis and Cartilage, 18(11), 1528-1535. ELSEVIER SCI LTD
Objective: In this study, we aim at tuning the differentiation of periosteum in an organ culture model towards cartilage, rich in collagen type II, using combinations of biochemical and mechanical stimuli. We hypothesize that addition of TGF-beta wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a30908ebb9cb502872dad20d172c03e
https://cris.maastrichtuniversity.nl/en/publications/4f6a07e8-5f0e-4b9d-bbd6-8ca7e3a5e2cc
https://cris.maastrichtuniversity.nl/en/publications/4f6a07e8-5f0e-4b9d-bbd6-8ca7e3a5e2cc
Publikováno v:
Regenerative Medicine. 4:S63-S108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e307fe2edd02e2816f1d0b83aa6bec
https://doi.org/10.2217/rme.09.s4
https://doi.org/10.2217/rme.09.s4
Publikováno v:
Regenerative Medicine. 4:S155-S224
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a33dad408879aed5de1a78f5a42199
https://doi.org/10.2217/rme.09.s6
https://doi.org/10.2217/rme.09.s6
Autor:
Ronny M. Schulz, van Cc René Donkelaar
Publikováno v:
Recent Patents on Biomedical Engineeringe. 1:1-12
To repair articular cartilage defects in osteoarthritic patients with three-dimensional tissue engineered chondrocyte grafts, requires the formation of new cartilage with sufficient mechanical properties. The premise is that mechanical stimulation du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ac76b16c0da28e1ef89470af732cde
https://doi.org/10.2174/1874764710801010001
https://doi.org/10.2174/1874764710801010001
Publikováno v:
Biomechanics and Modeling in Mechanobiology, 6(1-2), 43-53. Springer
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
For this study, we hypothesized that the depth-dependent compressive equilibrium properties of articular cartilage are the inherent consequence of its depth-dependent composition, and not the result of depth-dependent material properties. To test thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8c7306545d56780ba282a4e73f8af5
https://research.tue.nl/en/publications/0beb136e-643a-468e-a284-6a75bdc38648
https://research.tue.nl/en/publications/0beb136e-643a-468e-a284-6a75bdc38648
Publikováno v:
Journal of Anatomy, 210(2), 186-194. Wiley-Blackwell
Gradients in the concentrations of free phosphate (Pi) and calcium (Ca) exist in fully developed growth zones of long bones and ribs, with the highest concentrations closest to the site of mineralization. As high concentrations of Pi and Ca induce ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170d80aff9d393c89c5013415215b3d4
https://research.tue.nl/en/publications/e22fa132-7402-4efb-9887-5c53fe395eee
https://research.tue.nl/en/publications/e22fa132-7402-4efb-9887-5c53fe395eee