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Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

Autor: Broekgaarden, M., Van Vught, R., Oliveira, Sabrina, Roovers, R. C., Van Bergen En Henegouwen, P. M P, Pieters, R. J., Van Gulik, T. M., Breukink, E., Heger, M., Membrane Biochemistry and Biophysics, Medicinal Chemistry and Chemical Biology, Celbiologie, Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Sub Cell Biology, Sub Drug delivery, Sub Medicinal Chemistry & Chemical biol.

Publikováno v: Nanoscale, 8(12), 6490-6494. Royal Society of Chemistry
Nanoscale, 8(12), 6490. Royal Society of Chemistry

Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64185e2e877f2a35083c24d763e8495f
https://pure.amc.nl/en/publications/sitespecific-conjugation-of-single-domain-antibodies-to-liposomes-enhances-photosensitizer-uptake-and-photodynamic-therapy-efficacy(4cf8c98a-4316-4667-8056-7bbb3bf098b5).html

A novel immuno-gold labeling protocol for nanobody-based detection of HER2 in breast cancer cells using immuno-electron microscopy

Autor: Kijanka, M, van Donselaar, E G, Müller, W H, Dorresteijn, B, Popov-Celeketic, Dusan, El Khattabi, M, Verrips, C T, van Bergen En Henegouwen, P M P, Post, J A, Sub Cell Biology, Sub Biomolecular Imaging, Sub Cryo - EM, Celbiologie

Publikováno v: Journal of Structural Biology, 199(1), 1. Academic Press Inc.

Immuno-electron microscopy is commonly performed with the use of antibodies. In the last decade the antibody fragment indicated as nanobody (VHH or single domain antibody) has found its way to different applications previously done with conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6804f735f89555283d68bcbc12c1120a
https://hdl.handle.net/1874/359369

Nanobodies in therapeutic applications

Autor: Roovers, Rob C., Van Dongen, G. A M S, Van Bergen En Henegouwen, P. M P

Publikováno v: Roovers, R C, Van Dongen, G A M S & Van Bergen En Henegouwen, P M P 2007, ' Nanobodies in therapeutic applications ', Current Opinion in Molecular Therapeutics, vol. 9, no. 4, pp. 327-335 .

Over the years, many antibodies have been successfully generated to treat patients with life-threatening diseases, most notably cancer. While the first generation of antibodies, originating from mice, caused severe side effects and were relatively in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10172::cdaaaea4cf952236b66572e094de6bc2
https://research.vumc.nl/en/publications/01cf51ee-8f0a-4a98-a574-05a3ee150c3e

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