Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study

Autor: van Goudoever Johannes B, van Zonneveld Piet, Nelen Willianne LDM, Tonch Nino, van der Veen Fulco, Dykgraaf Ramon HM, Severens Johan L, van der Hoeven Mark AHBM, Evers Johannes LH, Dumoulin John CM, Bonsel Gouke J, van Heesch Mirjam MJ, Tamminga Pieter, Steiner Katerina, Koopman-Esseboom Corine, van Beijsterveldt Catharina EM, Boomsma Dorret I, Snellen Diana, Dirksen Carmen D

Publikováno v: BMC Pediatrics, Vol 10, Iss 1, p 75 (2010)

Abstract Background Pregnancies induced by in vitro fertilisation (IVF) often result in twin gestations, which are associated with both maternal and perinatal complications. An effective way to reduce the number of IVF twin pregnancies is to decrease

Externí odkaz: https://doaj.org/article/72b3b413ed8343dd96002a2d96c2eb41

Genome-wide associations for birth weight and correlations with adult disease

Autor: Horikoshi, Momoko, Beaumont, Robin N, Day, Felix R, Warrington, Nicole M, Kooijman, Marjolein N, Fernandez-Tajes, Juan, Feenstra, Bjarke, van Zuydam, Natalie R, Gaulton, Kyle J, Grarup, Niels, Bradfield, Jonathan P, Strachan, David P, Li-Gao, Ruifang, Ahluwalia, Tarunveer S, Kreiner, Eskil, Rueedi, Rico, Lyytikäinen, Leo-Pekka, Cousminer, Diana L, Wu, Ying, Thiering, Elisabeth, Wang, Carol A, Have, Christian T, Hottenga, Jouke-Jan, Vilor-Tejedor, Natalia, Joshi, Peter K, Boh, Eileen Tai Hui, Ntalla, Ioanna, Pitkänen, Niina, Mahajan, Anubha, van Leeuwen, Elisabeth M, Joro, Raimo, Lagou, Vasiliki, Nodzenski, Michael, Diver, Louise A, Zondervan, Krina T, Bustamante, Mariona, Marques-Vidal, Pedro, Mercader, Josep M, Bennett, Amanda J, Rahmioglu, Nilufer, Nyholt, Dale R, Ma, Ronald Ching Wan, Tam, Claudia Ha Ting, Tam, Wing Hung, CHARGE Consortium Hematology Working Group, Ganesh, Santhi K, van Rooij, Frank Ja, Jones, Samuel E, Loh, Po-Ru, Ruth, Katherine S, Tuke, Marcus A, Tyrrell, Jessica, Wood, Andrew R, Yaghootkar, Hanieh, Scholtens, Denise M, Paternoster, Lavinia, Prokopenko, Inga, Kovacs, Peter, Atalay, Mustafa, Willems, Sara M, Panoutsopoulou, Kalliope, Wang, Xu, Carstensen, Lisbeth, Geller, Frank, Schraut, Katharina E, Murcia, Mario, van Beijsterveldt, Catharina Em, Willemsen, Gonneke, Appel, Emil VR, Fonvig, Cilius E, Trier, Caecilie, Tiesler, Carla Mt, Standl, Marie, Kutalik, Zoltán, Bonas-Guarch, Sílvia, Hougaard, David M, Sánchez, Friman, Torrents, David, Waage, Johannes, Hollegaard, Mads V, de Haan, Hugoline G, Rosendaal, Frits R, Medina-Gomez, Carolina, Ring, Susan M, Hemani, Gibran, McMahon, George, Robertson, Neil R, Groves, Christopher J, Langenberg, Claudia, Luan, Jian'an, Scott, Robert A, Zhao, Jing Hua, Mentch, Frank D, MacKenzie, Scott M, Reynolds, Rebecca M, Early Growth Genetics (EGG) Consortium, Lowe, William L, Tönjes, Anke, Stumvoll, Michael, Lindi, Virpi

Publikováno v: Nature, vol 538, iss 7624

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. Thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::3bb009436eef7df3d8769c51d073a500
https://escholarship.org/uc/item/80p11439

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Autor: Warrington, Nicole M, Beaumont, Robin N, Horikoshi, Momoko, Day, Felix R, Helgeland, Øyvind, Laurin, Charles, Bacelis, Jonas, Peng, Shouneng, Hao, Ke, Feenstra, Bjarke, Wood, Andrew R, Mahajan, Anubha, Tyrrell, Jessica, Robertson, Neil R, Rayner, N William, Qiao, Zhen, Moen, Gunn-Helen, Vaudel, Marc, Marsit, Carmen J, Chen, Jia, Nodzenski, Michael, Schnurr, Theresia M, Zafarmand, Mohammad H, Bradfield, Jonathan P, Grarup, Niels, Kooijman, Marjolein N, Li-Gao, Ruifang, Geller, Frank, Ahluwalia, Tarunveer S, Paternoster, Lavinia, Rueedi, Rico, Huikari, Ville, Hottenga, Jouke-Jan, Lyytikäinen, Leo-Pekka, Cavadino, Alana, Metrustry, Sarah, Cousminer, Diana L, Wu, Ying, Thiering, Elisabeth, Wang, Carol A, Have, Christian T, Vilor-Tejedor, Natalia, Joshi, Peter K, Painter, Jodie N, Ntalla, Ioanna, Myhre, Ronny, Pitkänen, Niina, Van Leeuwen, Elisabeth M, Joro, Raimo, Lagou, Vasiliki, Richmond, Rebecca C, Espinosa, Ana, Barton, Sheila J, Inskip, Hazel M, Holloway, John W, Santa-Marina, Loreto, Estivill, Xavier, Ang, Wei, Marsh, Julie A, Reichetzeder, Christoph, Marullo, Letizia, Hocher, Berthold, Lunetta, Kathryn L, Murabito, Joanne M, Relton, Caroline L, Kogevinas, Manolis, Chatzi, Leda, Allard, Catherine, Bouchard, Luigi, Hivert, Marie-France, Zhang, Ge, Muglia, Louis J, Heikkinen, Jani, EGG Consortium, Morgen, Camilla S, Van Kampen, Antoine HC, Van Schaik, Barbera DC, Mentch, Frank D, Langenberg, Claudia, Luan, Jian'an, Scott, Robert A, Zhao, Jing Hua, Hemani, Gibran, Ring, Susan M, Bennett, Amanda J, Gaulton, Kyle J, Fernandez-Tajes, Juan, Van Zuydam, Natalie R, Medina-Gomez, Carolina, De Haan, Hugoline G, Rosendaal, Frits R, Kutalik, Zoltán, Marques-Vidal, Pedro, Das, Shikta, Willemsen, Gonneke, Mbarek, Hamdi, Müller-Nurasyid, Martina, Standl, Marie, Appel, Emil VR, Fonvig, Cilius E, Trier, Caecilie, Van Beijsterveldt, Catharina EM, Murcia, Mario, Bustamante, Mariona, Bonas-Guarch, Sílvia, Hougaard, David M, Mercader, Josep M, Linneberg, Allan, Schraut, Katharina E, Lind, Penelope A, Medland, Sarah E, Shields, Beverley M, Knight, Bridget A, Chai, Jin-Fang, Panoutsopoulou, Kalliope, Bartels, Meike, Sánchez, Friman, Stokholm, Jakob, Torrents, David, Vinding, Rebecca K, Willems, Sara M, Atalay, Mustafa, Chawes, Bo L, Kovacs, Peter, Prokopenko, Inga, Tuke, Marcus A, Yaghootkar, Hanieh, Ruth, Katherine S, Jones, Samuel E, Loh, Po-Ru, Murray, Anna, Weedon, Michael N, Tönjes, Anke, Stumvoll, Michael, Michaelsen, Kim F, Eloranta, Aino-Maija, Lakka, Timo A, Van Duijn, Cornelia M, Kiess, Wieland, Körner, Antje, Niinikoski, Harri, Pahkala, Katja, Raitakari, Olli T, Jacobsson, Bo, Zeggini, Eleftheria, Dedoussis, George V, Teo, Yik-Ying, Saw, Seang-Mei, Montgomery, Grant W, Campbell, Harry, Wilson, James F, Vrijkotte, Tanja GM, Vrijheid, Martine, De Geus, Eco JCN, Hayes, M Geoffrey, Kadarmideen, Haja N, Holm, Jens-Christian, Beilin, Lawrence J, Pennell, Craig E, Heinrich, Joachim, Adair, Linda S, Borja, Judith B, Mohlke, Karen L, Eriksson, Johan G, Widén, Elisabeth E, Hattersley, Andrew T, Spector, Tim D, Kähönen, Mika, Viikari, Jorma S, Lehtimäki, Terho, Boomsma, Dorret I, Sebert, Sylvain, Vollenweider, Peter, Sørensen, Thorkild IA, Bisgaard, Hans, Bønnelykke, Klaus, Murray, Jeffrey C, Melbye, Mads, Nohr, Ellen A, Mook-Kanamori, Dennis O, Rivadeneira, Fernando, Hofman, Albert, Felix, Janine F, Jaddoe, Vincent WV, Hansen, Torben, Pisinger, Charlotta, Vaag, Allan A, Pedersen, Oluf, Uitterlinden, André G, Järvelin, Marjo-Riitta, Power, Christine, Hyppönen, Elina, Scholtens, Denise M, Lowe, William L, Davey Smith, George, Timpson, Nicholas J, Morris, Andrew P, Wareham, Nicholas J, Hakonarson, Hakon, Grant, Struan FA, Frayling, Timothy M, Lawlor, Debbie A, Njølstad, Pål R, Johansson, Stefan, Ong, Ken K, McCarthy, Mark I, Perry, John RB, Evans, David M, Freathy, Rachel M

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c691d04353c4eea64fbcf6b4f675b13f

Genome-wide associations for birth weight and correlations with adult disease.

Autor: Horikoshi M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Beaumont RN; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Warrington NM; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Kooijman MN; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Fernandez-Tajes J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Feenstra B; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., van Zuydam NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Gaulton KJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Pediatrics, University of California San Diego, La Jolla, California, USA., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bradfield JP; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Strachan DP; Population Health Research Institute, St George's University of London, London, Cranmer Terrace, UK., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Ahluwalia TS; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center, Gentofte, Denmark., Kreiner E; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Rueedi R; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Cousminer DL; Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Thiering E; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Wang CA; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Have CT; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hottenga JJ; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Vilor-Tejedor N; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain., Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Boh ETH; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Ntalla I; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., van Leeuwen EM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Joro R; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland., Lagou V; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; KUL - University of Leuven, Department of Neurosciences, Leuven, Belgium.; Translational Immunology Laboratory, VIB, Leuven, Belgium., Nodzenski M; Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, USA., Diver LA; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, UK., Bustamante M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.; Center for Genomic Regulation (CRG), Barcelona, Spain., Marques-Vidal P; Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Mercader JM; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Rahmioglu N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Nyholt DR; Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China., Tam WH; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China., Ganesh SK; Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., van Rooij FJ; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Jones SE; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Loh PR; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Ruth KS; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Tuke MA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Tyrrell J; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.; European Centre for Environment and Human Health, University of Exeter, Truro, UK., Wood AR; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Yaghootkar H; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Scholtens DM; Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, USA., Paternoster L; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Kovacs P; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany., Atalay M; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland., Willems SM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Panoutsopoulou K; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Carstensen L; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., Geller F; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., Schraut KE; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Murcia M; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.; FISABIO-Universitat Jaume I-Universitat de València, Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain., van Beijsterveldt CE; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Willemsen G; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Appel EVR; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fonvig CE; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Trier C; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Tiesler CM; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Standl M; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Bonas-Guarch S; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain., Hougaard DM; Danish Center for Neonatal Screening, Statens Serum Institute, Copenhagen, Denmark.; Department for Congenital Disorders, Statens Serum Institute, Copenhagen, Denmark., Sánchez F; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.; Computer Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain., Torrents D; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Waage J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Hollegaard MV; Danish Center for Neonatal Screening, Statens Serum Institute, Copenhagen, Denmark.; Department for Congenital Disorders, Statens Serum Institute, Copenhagen, Denmark., de Haan HG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Medina-Gomez C; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Ring SM; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Hemani G; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., McMahon G; School of Social and Community Medicine, University of Bristol, Bristol, UK., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Mentch FD; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., MacKenzie SM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Reynolds RM; BHF Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, Scotland, UK., Lowe WL Jr; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA., Tönjes A; Medical Department, University of Leipzig, Leipzig, Germany., Stumvoll M; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Medical Department, University of Leipzig, Leipzig, Germany., Lindi V; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland., Lakka TA; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Kiess W; Pediatric Research Center, Department of Women´s & Child Health, University of Leipzig, Leipzig, Germany., Körner A; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women´s & Child Health, University of Leipzig, Leipzig, Germany., Sørensen TI; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark., Niinikoski H; Department of Pediatrics, Turku University Hospital, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, Turku, Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Zeggini E; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Dedoussis GV; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Saw SM; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Singapore Eye Research Institute, Singapore, Singapore., Melbye M; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.; Department of Medicine, Stanford School of Medicine, Stanford, California, USA., Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Wilson JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK., Vrijheid M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain., de Geus EJ; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands.; EMGO Institute for Health and Care Research, VU University and VU University Medical Center, Amsterdam, the Netherlands., Boomsma DI; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Kadarmideen HN; Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Holm JC; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sebert S; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Finland., Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Beilin LJ; School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia., Newnham JP; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Pennell CE; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Heinrich J; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA., Borja JB; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Eriksson JG; National Institute for Health and Welfare, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Widén EE; Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hopital, Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland., Viikari JS; Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Medicine, University of Turku, Turku, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Vollenweider P; Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.; 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Publikováno v: Nature [Nature] 2016 Oct 13; Vol. 538 (7624), pp. 248-252. Date of Electronic Publication: 2016 Sep 28.