Oral Sessions

Autor: V. Pilla Reddy, Rudi Dierckx, van Aren Waarde, K. Ishiwata, Philippus Elsinga, Jurgen W. A. Sijbesma, Johannes H. Proost, Csaba Nyakas, Nisha Kuzhuppilly Ramakrishnan, Chantal Kwizera

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 39:155-303

Cutamesine (SA4503) is a selective sigma-1 receptor agonist, currently in Phase II clinical trials for depression and post stroke neurological disturbances. Cutamesine has been found to be effective in several rodent models of amnesia and depression.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15b2c3ee98ef7b60a0fdd134f4a90957
https://doi.org/10.1007/s00259-012-2221-x

P-glycoprotein activity and biological response

Autor: Philippus Elsinga, W Vaalburg, van Aren Waarde, NH Hendrikse, Joost Bart

Publikováno v: Vaalburg, W, Hendrikse, N H, Elsinga, P H, Bart, J & Van Waarde, A 2005, ' P-glycoprotein activity and biological response ', Toxicology and Applied Pharmacology, vol. 207, no. 2 SUPPL. https://doi.org/10.1016/j.taap.2005.03.027
Toxicology and Applied Pharmacology, 207(2 Suppl), 257-60. ACADEMIC PRESS INC ELSEVIER SCIENCE
Toxicology and Applied Pharmacology, 207(2 SUPPL.). Academic Press Inc.

P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most likely P-gp protects organs against endogenous and exogenous toxins by extruding toxic compounds such as chemotherapeutics and other drugs. Many drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e856252ac587f3d3590aa87c68a401f3
https://doi.org/10.1016/j.taap.2005.03.027

Development of an inexpensive, low attenuation styrofoam primate chair for use in a PET scanner

Autor: Philippus Elsinga, Rudie Kortekaas, RP Maguire, Klaus L. Leenders, van Aren Waarde

Publikováno v: Journal of medical primatology, 33(2), 78-82

Pharmacokinetic modelling of radiotracers for positron emission tomography (PET) imaging of neuroreceptors can be performed with time-activity data for brain and blood. We aimed to develop an alternative to withdrawal of arterial blood samples for ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84e5ea822baffed945466d5d63579db
https://doi.org/10.1111/j.1600-0684.2004.00056.x

Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system

Autor: van Aren Waarde, Jan Passchier

Publikováno v: European Journal of Nuclear Medicine. 28(1):113-129

The 5-HT1A subtype of receptors for the neurotransmitter serotonin is predominantly located in the limbic forebrain and is involved in the modulation of emotion and the function of the hypothalamus. Since 5-HT1A receptors are implicated in the pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1055efccf45d3c23e611e5d080e2f256
https://hdl.handle.net/11370/244aeb5d-b12b-429d-a9b9-f1be4da11771

Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier

Autor: Philippus Elsinga, P Doze, NH Hendrikse, W Vaalburg, van Aren Waarde

Publikováno v: SYNAPSE, 36(1), 66-74. Wiley-Liss Inc.
Doze, P, Van Waarde, A, Elsinga, P H, Hendrikse, N H & Vaalburg, W 2000, ' Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier ', SYNAPSE, vol. 36, no. 1, pp. 66-74 . https://doi.org/10.1002/(SICI)1098-2396(200004)36:1<66::AID-SYN7>3.0.CO;2-J
Synapse, 36(1), 66-74. WILEY-LISS

Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the β-adrenergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5852484b90ee6da5467375c39271f0e
https://hdl.handle.net/11370/42f0e76b-2ad7-4aad-bdb4-da4506a969a1